======= CLIP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CLIP3
  * **<color #00a2e8>Official Name</color>**: CAP-Gly domain containing linker protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=25999|25999]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96DZ5|Q96DZ5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CLIP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CLIP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607382|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269|PubMed:19139280}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CAP GLY|
|Ank 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ganglioside binding|
|chaperone-mediated protein transport|
|negative regulation of microtubule polymerization|
|peptidyl-L-cysteine S-palmitoylation|
|peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine|
|protein palmitoylation|
|Golgi stack|
|negative regulation of microtubule polymerization or depolymerization|
|peptidyl-cysteine modification|
|membrane biogenesis|
|positive regulation of glucose transmembrane transport|
|regulation of microtubule polymerization|
|positive regulation of protein localization to plasma membrane|
|regulation of tumor necrosis factor-mediated signaling pathway|
|positive regulation of protein localization to cell periphery|
|negative regulation of protein polymerization|
|regulation of glucose transmembrane transport|
|regulation of microtubule polymerization or depolymerization|
|recycling endosome membrane|
|protein lipidation|
|lipoprotein biosynthetic process|
|trans-Golgi network membrane|
|regulation of protein localization to plasma membrane|
|positive regulation of endocytosis|
|fat cell differentiation|
|regulation of protein localization to cell periphery|
|lipoprotein metabolic process|
|positive regulation of protein localization to membrane|
|negative regulation of supramolecular fiber organization|
|negative regulation of protein complex assembly|
|negative regulation of cytoskeleton organization|
|early endosome membrane|
|regulation of cytokine-mediated signaling pathway|
|trans-Golgi network|
|regulation of response to cytokine stimulus|
|protein acylation|
|regulation of microtubule cytoskeleton organization|
|regulation of protein localization to membrane|
|positive regulation of transmembrane transport|
|regulation of endocytosis|
|regulation of microtubule-based process|
|regulation of protein polymerization|
|membrane raft|
|microtubule binding|
|positive regulation of cellular protein localization|
|regulation of supramolecular fiber organization|
|negative regulation of organelle organization|
|regulation of protein complex assembly|
|regulation of cellular protein localization|
|regulation of cytoskeleton organization|
|regulation of vesicle-mediated transport|
|regulation of transmembrane transport|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|positive regulation of transport|
|positive regulation of protein phosphorylation|
|regulation of protein localization|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of organelle organization|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|protein transport|
|peptide transport|
|regulation of apoptotic process|
|regulation of programmed cell death|
|amide transport|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|regulation of cell death|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|nitrogen compound transport|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7172
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CLIP3 Expression in NALM6 Cells: 1.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>