======= CNGA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNGA3
  * **<color #00a2e8>Official Name</color>**: cyclic nucleotide gated channel subunit alpha 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1261|1261]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16281|Q16281]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNGA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNGA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600053|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. {ECO:0000250, ECO:0000269|PubMed:10888875}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|cNMP binding|
|Ion trans|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transmembrane transporter complex|
|intracellular cGMP-activated cation channel activity|
|intracellular cAMP-activated cation channel activity|
|glial cell projection|
|ligand-gated ion channel activity|
|cGMP binding|
|axon initial segment|
|response to magnesium ion|
|inorganic cation import across plasma membrane|
|inorganic ion import across plasma membrane|
|import across plasma membrane|
|response to cAMP|
|perikaryon|
|response to organophosphorus|
|response to purine-containing compound|
|response to corticosteroid|
|protein C-terminus binding|
|visual perception|
|sensory perception of light stimulus|
|response to steroid hormone|
|response to metal ion|
|dendrite|
|response to inorganic substance|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|import into cell|
|cation transport|
|response to lipid|
|response to hormone|
|response to organic cyclic compound|
|ion transmembrane transport|
|sensory perception|
|response to organonitrogen compound|
|response to nitrogen compound|
|transmembrane transport|
|ion transport|
|nervous system process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5978
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNGA3 Expression in NALM6 Cells: -0.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>