======= CNOT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CNOT1
  * **<color #00a2e8>Official Name</color>**: CCR4-NOT transcription complex subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23019|23019]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A5YKK6|A5YKK6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CNOT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CNOT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604917|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Not1|
|DUF3819|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CCR4-NOT core complex|
|positive regulation of cytoplasmic mRNA processing body assembly|
|negative regulation of retinoic acid receptor signaling pathway|
|regulation of cytoplasmic mRNA processing body assembly|
|armadillo repeat domain binding|
|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|retinoic acid receptor binding|
|poly(A)-specific ribonuclease activity|
|negative regulation of intracellular estrogen receptor signaling pathway|
|regulation of nuclear-transcribed mRNA poly(A) tail shortening|
|regulation of retinoic acid receptor signaling pathway|
|CCR4-NOT complex|
|positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|nuclear-transcribed mRNA poly(A) tail shortening|
|regulation of stem cell population maintenance|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of intracellular estrogen receptor signaling pathway|
|RNA phosphodiester bond hydrolysis, exonucleolytic|
|estrogen receptor binding|
|gene silencing by miRNA|
|molecular adaptor activity|
|positive regulation of mRNA catabolic process|
|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|
|posttranscriptional gene silencing by RNA|
|signal transduction involved in mitotic DNA integrity checkpoint|
|intracellular signal transduction involved in G1 DNA damage checkpoint|
|signal transduction involved in mitotic DNA damage checkpoint|
|signal transduction involved in mitotic cell cycle checkpoint|
|signal transduction involved in mitotic G1 DNA damage checkpoint|
|posttranscriptional gene silencing|
|nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay|
|mitotic G1/S transition checkpoint|
|mitotic G1 DNA damage checkpoint|
|G1 DNA damage checkpoint|
|signal transduction involved in DNA damage checkpoint|
|signal transduction involved in DNA integrity checkpoint|
|signal transduction involved in cell cycle checkpoint|
|positive regulation of organelle assembly|
|regulation of intracellular steroid hormone receptor signaling pathway|
|positive regulation of mRNA metabolic process|
|DNA damage response, signal transduction by p53 class mediator|
|positive regulation of cell cycle arrest|
|P-body|
|gene silencing by RNA|
|mitotic DNA damage checkpoint|
|negative regulation of G1/S transition of mitotic cell cycle|
|signal transduction in response to DNA damage|
|mitotic DNA integrity checkpoint|
|negative regulation of cell cycle G1/S phase transition|
|regulation of cell cycle arrest|
|signal transduction by p53 class mediator|
|negative regulation of translation|
|DNA damage checkpoint|
|DNA integrity checkpoint|
|negative regulation of cellular amide metabolic process|
|regulation of G1/S transition of mitotic cell cycle|
|gene silencing|
|mitotic cell cycle checkpoint|
|RNA phosphodiester bond hydrolysis|
|regulation of cell cycle G1/S phase transition|
|cell cycle checkpoint|
|nuclear-transcribed mRNA catabolic process|
|regulation of mRNA catabolic process|
|negative regulation of mitotic cell cycle phase transition|
|mRNA catabolic process|
|regulation of organelle assembly|
|negative regulation of cell cycle phase transition|
|regulation of gene expression, epigenetic|
|protein domain specific binding|
|RNA catabolic process|
|positive regulation of protein complex assembly|
|positive regulation of cell cycle process|
|nucleic acid phosphodiester bond hydrolysis|
|negative regulation of mitotic cell cycle|
|negative regulation of cell cycle process|
|regulation of mRNA metabolic process|
|regulation of translation|
|positive regulation of cellular catabolic process|
|nucleobase-containing compound catabolic process|
|positive regulation of cell cycle|
|regulation of cellular amide metabolic process|
|regulation of mitotic cell cycle phase transition|
|positive regulation of catabolic process|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|organic cyclic compound catabolic process|
|positive regulation of cellular component biogenesis|
|posttranscriptional regulation of gene expression|
|negative regulation of cell cycle|
|mitotic cell cycle process|
|positive regulation of organelle organization|
|regulation of mitotic cell cycle|
|mitotic cell cycle|
|mRNA metabolic process|
|regulation of cell cycle process|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|regulation of catabolic process|
|cell cycle process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|negative regulation of protein metabolic process|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|extracellular space|
|negative regulation of response to stimulus|
|RNA metabolic process|
|intracellular signal transduction|
|cellular response to stress|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of nucleobase-containing compound metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.04|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-1.82|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|1.7|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|1.7|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.73|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.75|
|[[:results:exp187|proTAME 5μM R04 exp187]]|1.75|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.95|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|1.95|
|[[:results:exp461|BS-181 20μM R08 exp461]]|1.99|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|2.03|
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|2.03|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.47|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdc73|CDC73]]|0.516|
|[[:human genes:c:cope|COPE]]|0.476|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.47|
|[[:human genes:v:vasn|VASN]]|0.462|
|[[:human genes:c:cdca3|CDCA3]]|0.455|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.451|
|[[:human genes:m:myo1h|MYO1H]]|0.45|
|[[:human genes:c:chaf1a|CHAF1A]]|0.446|
|[[:human genes:c:ckap5|CKAP5]]|0.445|
|[[:human genes:t:tceb3c|TCEB3C]]|0.441|
|[[:human genes:r:rpsa|RPSA]]|0.441|
|[[:human genes:p:psmb4|PSMB4]]|0.44|
|[[:human genes:s:smg7|SMG7]]|0.439|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.439|
|[[:human genes:c:c14orf93|C14orf93]]|0.438|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.433|
|[[:human genes:r:rffl|RFFL]]|0.431|
|[[:human genes:s:smg1|SMG1]]|0.43|
|[[:human genes:p:pold1|POLD1]]|0.428|
|[[:human genes:z:zfand5|ZFAND5]]|0.427|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.424|
|[[:human genes:z:znf830|ZNF830]]|0.423|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.422|
|[[:human genes:s:ssh2|SSH2]]|0.421|
|[[:human genes:z:znf106|ZNF106]]|0.421|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.421|
|[[:human genes:n:ndc1|NDC1]]|0.411|
|[[:human genes:p:paf1|PAF1]]|0.408|
|[[:human genes:c:cdk8|CDK8]]|0.406|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.406|
|[[:human genes:z:znf655|ZNF655]]|0.406|
|[[:human genes:p:psma6|PSMA6]]|0.405|
|[[:human genes:b:bod1l1|BOD1L1]]|0.402|
|[[:human genes:n:nup188|NUP188]]|0.402|
|[[:human genes:d:dtl|DTL]]|0.401|
|[[:human genes:s:syt9|SYT9]]|0.4|
|[[:human genes:r:rbbp5|RBBP5]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 199/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|9/28|
|blood|11/28|
|bone|5/26|
|breast|9/33|
|central nervous system|14/56|
|cervix|1/4|
|colorectal|2/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|5/21|
|liver|6/20|
|lung|20/75|
|lymphocyte|8/16|
|ovary|5/26|
|pancreas|8/24|
|peripheral nervous system|2/16|
|plasma cell|7/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|9/22|
|urinary tract|12/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 387
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CNOT1 Expression in NALM6 Cells: 8.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>