======= COA5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COA5
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase assembly factor 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=493753|493753]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q86WW8|Q86WW8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COA5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COA5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613920|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an ortholog of yeast Pet191, which in yeast is a subunit of a large oligomeric complex associated with the mitochondrial inner membrane, and required for the assembly of the cytochrome c oxidase complex. Mutations in this gene are associated with mitochondrial complex IV deficiency, a disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to a severe disease affecting several tissues and organs. [provided by RefSeq, Dec 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in an early step of the mitochondrial complex IV assembly process. {ECO:0000269|PubMed:21457908}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pet191 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex IV assembly|
|respiratory chain complex IV assembly|
|cytochrome complex assembly|
|mitochondrial respiratory chain complex assembly|
|mitochondrion organization|
|cellular protein-containing complex assembly|
|mitochondrion|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.96|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|-1.93|
|[[:results:exp272|CHIR-124 0.04μM R06 exp272]]|-1.88|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.73|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.72|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|1.71|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.74|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|1.76|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.86|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.31|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cox17|COX17]]|0.558|
|[[:human genes:c:cox16|COX16]]|0.557|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.547|
|[[:human genes:c:coa3|COA3]]|0.539|
|[[:human genes:m:mrps2|MRPS2]]|0.534|
|[[:human genes:m:mrpl23|MRPL23]]|0.53|
|[[:human genes:m:mtpap|MTPAP]]|0.519|
|[[:human genes:s:sars2|SARS2]]|0.518|
|[[:human genes:f:fastkd5|FASTKD5]]|0.518|
|[[:human genes:f:fars2|FARS2]]|0.511|
|[[:human genes:s:selrc1|SELRC1]]|0.51|
|[[:human genes:m:mrpl21|MRPL21]]|0.506|
|[[:human genes:m:mrps14|MRPS14]]|0.504|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.503|
|[[:human genes:m:mrpl33|MRPL33]]|0.501|
|[[:human genes:c:cox7b|COX7B]]|0.499|
|[[:human genes:c:cox6b1|COX6B1]]|0.496|
|[[:human genes:m:mrps5|MRPS5]]|0.495|
|[[:human genes:m:mrps6|MRPS6]]|0.492|
|[[:human genes:v:vars2|VARS2]]|0.491|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.489|
|[[:human genes:m:mrpl47|MRPL47]]|0.488|
|[[:human genes:t:tufm|TUFM]]|0.486|
|[[:human genes:m:mrps12|MRPS12]]|0.486|
|[[:human genes:d:dars2|DARS2]]|0.484|
|[[:human genes:s:sco2|SCO2]]|0.477|
|[[:human genes:q:qrsl1|QRSL1]]|0.471|
|[[:human genes:r:rpusd4|RPUSD4]]|0.47|
|[[:human genes:m:mrps9|MRPS9]]|0.47|
|[[:human genes:g:gfm1|GFM1]]|0.468|
|[[:human genes:d:dap3|DAP3]]|0.467|
|[[:human genes:m:mrps18a|MRPS18A]]|0.465|
|[[:human genes:b:bcs1l|BCS1L]]|0.463|
|[[:human genes:m:mrp63|MRP63]]|0.461|
|[[:human genes:y:yars2|YARS2]]|0.459|
|[[:human genes:m:mrps25|MRPS25]]|0.458|
|[[:human genes:c:cycs|CYCS]]|0.456|
|[[:human genes:m:mrps16|MRPS16]]|0.453|
|[[:human genes:m:mtg2|MTG2]]|0.452|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.447|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.446|
|[[:human genes:m:mrps34|MRPS34]]|0.445|
|[[:human genes:m:mrps26|MRPS26]]|0.445|
|[[:human genes:t:tars2|TARS2]]|0.444|
|[[:human genes:p:pars2|PARS2]]|0.442|
|[[:human genes:m:mrpl36|MRPL36]]|0.439|
|[[:human genes:s:slc25a26|SLC25A26]]|0.435|
|[[:human genes:p:pnpt1|PNPT1]]|0.435|
|[[:human genes:h:higd2a|HIGD2A]]|0.435|
|[[:human genes:m:mrpl15|MRPL15]]|0.434|
|[[:human genes:m:mrpl18|MRPL18]]|0.433|
|[[:human genes:p:pdss1|PDSS1]]|0.432|
|[[:human genes:m:mrpl34|MRPL34]]|0.431|
|[[:human genes:t:trub2|TRUB2]]|0.427|
|[[:human genes:c:coa6|COA6]]|0.427|
|[[:human genes:a:aifm1|AIFM1]]|0.426|
|[[:human genes:m:mrpl3|MRPL3]]|0.425|
|[[:human genes:w:wbscr16|WBSCR16]]|0.425|
|[[:human genes:m:mrpl4|MRPL4]]|0.425|
|[[:human genes:m:mrps21|MRPS21]]|0.423|
|[[:human genes:c:cox6c|COX6C]]|0.423|
|[[:human genes:m:mrpl53|MRPL53]]|0.422|
|[[:human genes:m:mrps23|MRPS23]]|0.417|
|[[:human genes:h:hars2|HARS2]]|0.416|
|[[:human genes:m:mars2|MARS2]]|0.415|
|[[:human genes:t:tomm22|TOMM22]]|0.411|
|[[:human genes:c:c17orf89|C17orf89]]|0.407|
|[[:human genes:m:mrpl55|MRPL55]]|0.405|
|[[:human genes:a:atp5c1|ATP5C1]]|0.404|
|[[:human genes:m:mrpl45|MRPL45]]|0.404|
|[[:human genes:c:cox11|COX11]]|0.403|
|[[:human genes:m:mtfmt|MTFMT]]|0.403|
|[[:human genes:c:cox15|COX15]]|0.402|
|[[:human genes:m:mrpl20|MRPL20]]|0.402|
|[[:human genes:g:gfm2|GFM2]]|0.401|
|[[:human genes:u:uqcr10|UQCR10]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|1/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|0/20|
|lung|2/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 39
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COA5 Expression in NALM6 Cells: 4.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>