======= COL4A3BP =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CERT1
  * **<color #00a2e8>Official Name</color>**: ceramide transporter 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10087|10087]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5P4|Q9Y5P4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL4A3BP&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL4A3BP|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604677|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|START|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intermembrane sphingolipid transfer|
|ceramide transfer activity|
|ceramide binding|
|ER to Golgi ceramide transport|
|ceramide 1-phosphate binding|
|ceramide 1-phosphate transport|
|ceramide 1-phosphate transfer activity|
|intermembrane lipid transfer|
|ceramide transport|
|mitochondrion morphogenesis|
|phosphatidylinositol-4-phosphate binding|
|intracellular lipid transport|
|endoplasmic reticulum organization|
|kinase activity|
|ceramide metabolic process|
|sphingolipid biosynthetic process|
|phospholipid transport|
|organophosphate ester transport|
|membrane lipid biosynthetic process|
|lipid homeostasis|
|sphingolipid metabolic process|
|lipid binding|
|membrane lipid metabolic process|
|muscle contraction|
|heart morphogenesis|
|response to endoplasmic reticulum stress|
|lipid transport|
|muscle system process|
|lipid localization|
|in utero embryonic development|
|endomembrane system organization|
|mitochondrion organization|
|organic anion transport|
|cell part morphogenesis|
|heart development|
|cell population proliferation|
|lipid biosynthetic process|
|anion transport|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|cellular amide metabolic process|
|cellular component morphogenesis|
|membrane organization|
|circulatory system development|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|embryo development|
|Golgi apparatus|
|chemical homeostasis|
|lipid metabolic process|
|mitochondrion|
|phosphorylation|
|ion transport|
|organonitrogen compound biosynthetic process|
|intracellular transport|
|amide transport|
|homeostatic process|
|cellular response to stress|
|establishment of localization in cell|
|nitrogen compound transport|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.91|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-3.52|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.62|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-2.46|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|-2.38|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-2.34|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-2.26|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.24|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|-2.23|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.22|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.21|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-1.86|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sgms1|SGMS1]]|0.597|
|[[:human genes:s:sptlc1|SPTLC1]]|0.56|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.512|
|[[:human genes:s:sptlc2|SPTLC2]]|0.465|
|[[:human genes:f:fam91a1|FAM91A1]]|0.457|
|[[:human genes:w:wdr11|WDR11]]|0.414|
|[[:human genes:c:cog5|COG5]]|0.412|
|[[:human genes:v:vkorc1l1|VKORC1L1]]|0.408|
|[[:human genes:p:pi4kb|PI4KB]]|0.406|
|[[:human genes:u:unc50|UNC50]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11439
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL4A3BP Expression in NALM6 Cells: 5.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>