======= COL5A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COL5A1
  * **<color #00a2e8>Official Name</color>**: collagen type V alpha 1 chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1289|1289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P20908|P20908]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL5A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL5A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120215|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. The encoded procollagen protein occurs commonly as the heterotrimer pro-alpha1(V)-pro-alpha1(V)-pro-alpha2(V). Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Laminin G 2|
|COLFI|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|integrin biosynthetic process|
|collagen type V trimer|
|negative regulation of endodermal cell differentiation|
|regulation of endodermal cell differentiation|
|tendon development|
|negative regulation of gastrulation|
|collagen biosynthetic process|
|wound healing, spreading of epidermal cells|
|platelet-derived growth factor binding|
|proteoglycan binding|
|epiboly involved in wound healing|
|wound healing, spreading of cells|
|epiboly|
|negative regulation of embryonic development|
|regulation of gastrulation|
|extracellular matrix structural constituent conferring tensile strength|
|collagen fibril organization|
|morphogenesis of an epithelial sheet|
|collagen metabolic process|
|basement membrane|
|plasma membrane organization|
|regulation of embryonic development|
|integrin binding|
|extracellular matrix structural constituent|
|eye morphogenesis|
|heparin binding|
|connective tissue development|
|extracellular matrix|
|heart morphogenesis|
|sensory organ morphogenesis|
|endoplasmic reticulum lumen|
|extracellular matrix organization|
|eye development|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|skin development|
|extracellular structure organization|
|endomembrane system organization|
|morphogenesis of an epithelium|
|supramolecular fiber organization|
|wound healing|
|blood vessel development|
|vasculature development|
|cardiovascular system development|
|heart development|
|sensory organ development|
|tissue morphogenesis|
|response to wounding|
|negative regulation of cell differentiation|
|membrane organization|
|circulatory system development|
|cell adhesion|
|biological adhesion|
|negative regulation of developmental process|
|animal organ morphogenesis|
|cell migration|
|regulation of anatomical structure morphogenesis|
|cell motility|
|localization of cell|
|epithelium development|
|negative regulation of multicellular organismal process|
|locomotion|
|movement of cell or subcellular component|
|extracellular space|
|tissue development|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|1.94|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10365
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.51 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL5A1 Expression in NALM6 Cells: 4.51'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>