======= COL5A2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COL5A2
  * **<color #00a2e8>Official Name</color>**: collagen type V alpha 2 chain
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1290|1290]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P05997|P05997]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COL5A2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COL5A2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/120190|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COLFI|
|Collagen|
|VWC|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of endodermal cell differentiation|
|collagen type V trimer|
|regulation of endodermal cell differentiation|
|negative regulation of gastrulation|
|notochord development|
|negative regulation of embryonic development|
|regulation of gastrulation|
|extracellular matrix structural constituent conferring tensile strength|
|collagen fibril organization|
|SMAD binding|
|collagen trimer|
|cellular response to amino acid stimulus|
|response to amino acid|
|regulation of embryonic development|
|extracellular matrix structural constituent|
|eye morphogenesis|
|cellular response to acid chemical|
|extracellular matrix|
|sensory organ morphogenesis|
|ossification|
|endoplasmic reticulum lumen|
|extracellular matrix organization|
|response to acid chemical|
|eye development|
|visual system development|
|collagen-containing extracellular matrix|
|sensory system development|
|skin development|
|extracellular structure organization|
|embryonic organ development|
|supramolecular fiber organization|
|skeletal system development|
|sensory organ development|
|cellular response to organonitrogen compound|
|cellular response to nitrogen compound|
|negative regulation of cell differentiation|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|response to nitrogen compound|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|extracellular space|
|regulation of cell differentiation|
|protein-containing complex subunit organization|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|1.76|
|[[:results:exp519|RS-1 10μM R08 exp519]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.455|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12936
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COL5A2 Expression in NALM6 Cells: -0.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>