======= COLEC12 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COLEC12
  * **<color #00a2e8>Official Name</color>**: collectin subfamily member 12
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81035|81035]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5KU26|Q5KU26]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COLEC12&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COLEC12|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor, a cell surface glycoprotein that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells. [provided by RefSeq, Oct 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. {ECO:0000269|PubMed:11162630, ECO:0000269|PubMed:11564734, ECO:0000269|PubMed:12761161, ECO:0000269|PubMed:15845541, ECO:0000269|PubMed:16868960}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Lectin C|
|Collagen|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cell adhesion molecule production|
|galactose binding|
|carbohydrate mediated signaling|
|regulation of cell adhesion molecule production|
|signaling pattern recognition receptor activity|
|toll-like receptor 3 signaling pathway|
|low-density lipoprotein particle binding|
|cellular response to exogenous dsRNA|
|cellular response to dsRNA|
|response to exogenous dsRNA|
|scavenger receptor activity|
|response to dsRNA|
|collagen trimer|
|endocytic vesicle membrane|
|cellular response to carbohydrate stimulus|
|toll-like receptor signaling pathway|
|phagocytosis, recognition|
|pattern recognition receptor signaling pathway|
|response to carbohydrate|
|extracellular matrix|
|innate immune response-activating signal transduction|
|receptor-mediated endocytosis|
|cell recognition|
|activation of innate immune response|
|phagocytosis|
|protein homooligomerization|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|protein complex oligomerization|
|regulation of response to biotic stimulus|
|cellular response to organic cyclic compound|
|endocytosis|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|activation of immune response|
|cellular response to nitrogen compound|
|import into cell|
|regulation of defense response|
|innate immune response|
|regulation of multi-organism process|
|positive regulation of immune response|
|response to organic cyclic compound|
|defense response to other organism|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|regulation of response to external stimulus|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|response to oxygen-containing compound|
|protein-containing complex assembly|
|extracellular space|
|regulation of immune system process|
|protein-containing complex subunit organization|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp112|S-DABN 8μM R03 exp112]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6074
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COLEC12 Expression in NALM6 Cells: 4.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>