======= COPG1 ======= == Gene Information == * **Official Symbol**: COPG1 * **Official Name**: COPI coat complex subunit gamma 1 * **Aliases and Previous Symbols**: N/A * **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22820|22820]] * **UniProt**: [[https://www.uniprot.org/uniprot/Q9Y678|Q9Y678]] * **Interactions**: [[https://thebiogrid.org/search.php?search=COPG1&organism=9606|BioGRID]] * **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COPG1|Open PubMed]] * **OMIM**: [[https://omim.org/entry/615525|Open OMIM]] == Function Summary == * **Entrez Summary**: N/A * **UniProt Summary**: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte triglyceride lipase (PNPLA2) with the lipid droplet surface to mediate lipolysis (By similarity). {ECO:0000250, ECO:0000269|PubMed:20674546}. |Gamma-COP| |Adaptin N| |establishment of Golgi localization| |Golgi localization| |COPI vesicle coat| |intra-Golgi vesicle-mediated transport| |endoplasmic reticulum-Golgi intermediate compartment| |organelle transport along microtubule| |retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum| |transport vesicle| |transport along microtubule| |protein secretion| |establishment of protein localization to extracellular region| |protein localization to extracellular region| |peptide secretion| |cytoskeleton-dependent intracellular transport| |microtubule-based transport| |structural molecule activity| |endoplasmic reticulum to Golgi vesicle-mediated transport| |microtubule-based movement| |establishment of organelle localization| |Golgi vesicle transport| |organelle localization| |Golgi membrane| |microtubule-based process| |endoplasmic reticulum membrane| |Golgi apparatus| |intracellular protein transport| |secretion by cell| |endoplasmic reticulum| |export from cell| |secretion| |protein transport| |intracellular transport| |peptide transport| |movement of cell or subcellular component| |amide transport| |cellular protein localization| |cellular macromolecule localization| |establishment of protein localization| |establishment of localization in cell| |nitrogen compound transport| |vesicle-mediated transport| |membrane| \\ === CRISPR Data === ^Screen^Score^ |[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-2.53| |[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.03| |[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|-1.95| |[[:results:exp17|DABN 20μM R00 exp17]]|-1.76| |[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-1.72| |[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.78| |[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.79| |[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|1.81| |[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.81| |[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|1.82| |[[:results:exp430|Rifampicin 30μM R08 exp430]]|1.83| |[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|1.84| |[[:results:exp220|BAY-598 4μM R05 exp220]]|1.85| |[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.93| |[[:results:exp215|Colchicine 0.009μM R05 exp215]]|2.1| |[[:results:exp314|Dimethyloxaloylglycine 11μM R07 exp314]]|2.14| |[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.19| ^Gene^Correlation^ |[[:human genes:c:copa|COPA]]|0.587| |[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.584| |[[:human genes:p:psmb4|PSMB4]]|0.582| |[[:human genes:c:c14orf93|C14orf93]]|0.578| |[[:human genes:p:psmb2|PSMB2]]|0.567| |[[:human genes:t:tceb3c|TCEB3C]]|0.564| |[[:human genes:m:mt1e|MT1E]]|0.562| |[[:human genes:d:dtl|DTL]]|0.56| |[[:human genes:n:nup160|NUP160]]|0.559| |[[:human genes:c:copz1|COPZ1]]|0.556| |[[:human genes:v:vps28|VPS28]]|0.555| |[[:human genes:c:copb2|COPB2]]|0.551| |[[:human genes:t:tceb3cl|TCEB3CL]]|0.549| |[[:human genes:c:ccna2|CCNA2]]|0.549| |[[:human genes:v:vps54|VPS54]]|0.547| |[[:human genes:v:vasn|VASN]]|0.541| |[[:human genes:u:utp3|UTP3]]|0.539| |[[:human genes:a:arcn1|ARCN1]]|0.536| |[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.534| |[[:human genes:c:chd4|CHD4]]|0.532| |[[:human genes:c:cbwd5|CBWD5]]|0.531| |[[:human genes:p:polr2f|POLR2F]]|0.531| |[[:human genes:k:kctd17|KCTD17]]|0.53| |[[:human genes:o:orc1|ORC1]]|0.53| |[[:human genes:s:slc6a17|SLC6A17]]|0.53| |[[:human genes:t:tfip11|TFIP11]]|0.528| |[[:human genes:c:cbwd3|CBWD3]]|0.528| |[[:human genes:c:copb1|COPB1]]|0.524| |[[:human genes:p:pan3|PAN3]]|0.523| |[[:human genes:t:ticrr|TICRR]]|0.523| |[[:human genes:n:npipb5|NPIPB5]]|0.519| |[[:human genes:p:polr2j3|POLR2J3]]|0.518| |[[:human genes:s:supt5h|SUPT5H]]|0.518| |[[:human genes:s:slc4a1|SLC4A1]]|0.518| |[[:human genes:t:tsg101|TSG101]]|0.516| |[[:human genes:p:psmd3|PSMD3]]|0.514| |[[:human genes:d:ddtl|DDTL]]|0.514| |[[:human genes:d:disp2|DISP2]]|0.512| |[[:human genes:f:fam160a1|FAM160A1]]|0.512| |[[:human genes:a:aamp|AAMP]]|0.51| |[[:human genes:p:psmd11|PSMD11]]|0.506| |[[:human genes:c:cbwd6|CBWD6]]|0.505| |[[:human genes:r:rrp7a|RRP7A]]|0.504| |[[:human genes:h:hist2h3a|HIST2H3A]]|0.503| |[[:human genes:h:hist2h3c|HIST2H3C]]|0.503| |[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.5| |[[:human genes:d:ddt|DDT]]|0.5| |[[:human genes:n:napa|NAPA]]|0.496| |[[:human genes:e:exosc9|EXOSC9]]|0.496| |[[:human genes:s:supt6h|SUPT6H]]|0.496| |[[:human genes:t:tyms|TYMS]]|0.496| |[[:human genes:s:sec13|SEC13]]|0.495| |[[:human genes:n:nsf|NSF]]|0.494| |[[:human genes:c:chaf1a|CHAF1A]]|0.493| |[[:human genes:a:atp1a3|ATP1A3]]|0.493| |[[:human genes:o:orc6|ORC6]]|0.493| |[[:human genes:k:kif3c|KIF3C]]|0.49| |[[:human genes:g:gar1|GAR1]]|0.49| |[[:human genes:r:rbm39|RBM39]]|0.489| |[[:human genes:p:phf2|PHF2]]|0.489| |[[:human genes:s:slc38a7|SLC38A7]]|0.489| |[[:human genes:n:nupl1|NUPL1]]|0.488| |[[:human genes:a:aatf|AATF]]|0.485| |[[:human genes:c:cox7a2l|COX7A2L]]|0.485| |[[:human genes:a:aqr|AQR]]|0.484| |[[:human genes:c:cep192|CEP192]]|0.484| |[[:human genes:m:myo1h|MYO1H]]|0.483| |[[:human genes:e:exosc5|EXOSC5]]|0.482| |[[:human genes:h:hap1|HAP1]]|0.482| |[[:human genes:e:exosc3|EXOSC3]]|0.482| |[[:human genes:a:atp6v0b|ATP6V0B]]|0.482| |[[:human genes:c:cdca3|CDCA3]]|0.48| |[[:human genes:s:snrpa1|SNRPA1]]|0.479| |[[:human genes:s:sf3a1|SF3A1]]|0.479| |[[:human genes:u:upf1|UPF1]]|0.477| |[[:human genes:g:golga6l3|GOLGA6L3]]|0.477| |[[:human genes:r:rps12|RPS12]]|0.476| |[[:human genes:t:twistnb|TWISTNB]]|0.476| |[[:human genes:n:narfl|NARFL]]|0.475| |[[:human genes:d:dock6|DOCK6]]|0.474| |[[:human genes:c:cactin|CACTIN]]|0.473| |[[:human genes:t:tbc1d3g|TBC1D3G]]|0.473| |[[:human genes:n:nfatc4|NFATC4]]|0.473| |[[:human genes:h:hist2h2bf|HIST2H2BF]]|0.473| |[[:human genes:c:cope|COPE]]|0.472| |[[:human genes:r:rbbp5|RBBP5]]|0.472| |[[:human genes:c:cdc73|CDC73]]|0.472| |[[:human genes:r:rpl35|RPL35]]|0.472| |[[:human genes:m:mylk3|MYLK3]]|0.471| |[[:human genes:p:psma6|PSMA6]]|0.471| |[[:human genes:r:ranbp2|RANBP2]]|0.471| |[[:human genes:p:psmc2|PSMC2]]|0.47| |[[:human genes:p:prim1|PRIM1]]|0.47| |[[:human genes:s:stil|STIL]]|0.469| |[[:human genes:h:hist1h2be|HIST1H2BE]]|0.469| |[[:human genes:b:brd2|BRD2]]|0.469| |[[:human genes:t:tbc1d3h|TBC1D3H]]|0.468| |[[:human genes:a:acsf2|ACSF2]]|0.468| |[[:human genes:p:polr2d|POLR2D]]|0.467| |[[:human genes:o:osbp|OSBP]]|0.466| |[[:human genes:b:bysl|BYSL]]|0.466| |[[:human genes:i:ints5|INTS5]]|0.465| |[[:human genes:z:znf830|ZNF830]]|0.465| |[[:human genes:c:ctage4|CTAGE4]]|0.464| |[[:human genes:p:paf1|PAF1]]|0.462| |[[:human genes:t:tbc1d3f|TBC1D3F]]|0.462| |[[:human genes:c:ccdc64b|CCDC64B]]|0.461| |[[:human genes:h:hnrnpc|HNRNPC]]|0.461| |[[:human genes:t:tp53tg3b|TP53TG3B]]|0.461| |[[:human genes:p:psma7|PSMA7]]|0.461| |[[:human genes:t:tp53tg3|TP53TG3]]|0.46| |[[:human genes:t:tp53tg3c|TP53TG3C]]|0.46| |[[:human genes:x:xab2|XAB2]]|0.46| |[[:human genes:a:atp6ap1|ATP6AP1]]|0.459| |[[:human genes:s:sf3a3|SF3A3]]|0.459| |[[:human genes:c:col2a1|COL2A1]]|0.458| |[[:human genes:m:myb|MYB]]|0.457| |[[:human genes:r:rpl30|RPL30]]|0.456| |[[:human genes:s:ssh2|SSH2]]|0.456| |[[:human genes:z:znf655|ZNF655]]|0.456| |[[:human genes:r:rps19|RPS19]]|0.455| |[[:human genes:m:mfsd12|MFSD12]]|0.455| |[[:human genes:u:ubap1|UBAP1]]|0.454| |[[:human genes:p:psmc5|PSMC5]]|0.454| |[[:human genes:r:riok2|RIOK2]]|0.453| |[[:human genes:p:pola1|POLA1]]|0.453| |[[:human genes:s:syt9|SYT9]]|0.451| |[[:human genes:a:atp6v1a|ATP6V1A]]|0.451| |[[:human genes:f:fam25b|FAM25B]]|0.449| |[[:human genes:n:nup85|NUP85]]|0.449| |[[:human genes:n:numa1|NUMA1]]|0.449| |[[:human genes:p:psmd7|PSMD7]]|0.449| |[[:human genes:m:myo18a|MYO18A]]|0.449| |[[:human genes:t:trappc11|TRAPPC11]]|0.447| |[[:human genes:g:gid4|GID4]]|0.447| |[[:human genes:h:hivep3|HIVEP3]]|0.447| |[[:human genes:g:golga6l6|GOLGA6L6]]|0.446| |[[:human genes:r:rrn3|RRN3]]|0.446| |[[:human genes:s:snx15|SNX15]]|0.446| |[[:human genes:t:tpx2|TPX2]]|0.445| |[[:human genes:t:tp53tg3d|TP53TG3D]]|0.444| |[[:human genes:r:rps2|RPS2]]|0.443| |[[:human genes:r:rrm1|RRM1]]|0.443| |[[:human genes:a:atp6v0c|ATP6V0C]]|0.443| |[[:human genes:n:nup54|NUP54]]|0.442| |[[:human genes:d:dhx38|DHX38]]|0.442| |[[:human genes:p:psmc1|PSMC1]]|0.442| |[[:human genes:d:ddx56|DDX56]]|0.442| |[[:human genes:p:pole|POLE]]|0.441| |[[:human genes:n:nufip2|NUFIP2]]|0.441| |[[:human genes:s:sh3bp1|SH3BP1]]|0.44| |[[:human genes:p:psmd2|PSMD2]]|0.44| |[[:human genes:t:tspy8|TSPY8]]|0.44| |[[:human genes:e:eif4a3|EIF4A3]]|0.44| |[[:human genes:p:psmd14|PSMD14]]|0.439| |[[:human genes:u:usp35|USP35]]|0.439| |[[:human genes:h:hnrnpa1|HNRNPA1]]|0.439| |[[:human genes:c:crnkl1|CRNKL1]]|0.438| |[[:human genes:v:vps52|VPS52]]|0.438| |[[:human genes:n:nbpf10|NBPF10]]|0.438| |[[:human genes:t:tuba8|TUBA8]]|0.437| |[[:human genes:r:rrp15|RRP15]]|0.437| |[[:human genes:i:iscu|ISCU]]|0.437| |[[:human genes:n:nol10|NOL10]]|0.436| |[[:human genes:g:golga6l1|GOLGA6L1]]|0.436| |[[:human genes:h:hist1h4b|HIST1H4B]]|0.435| |[[:human genes:r:rpl14|RPL14]]|0.435| |[[:human genes:l:lad1|LAD1]]|0.435| |[[:human genes:r:rnpc3|RNPC3]]|0.434| |[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.434| |[[:human genes:a:akirin2|AKIRIN2]]|0.433| |[[:human genes:t:tbc1d3e|TBC1D3E]]|0.433| |[[:human genes:c:cdc45|CDC45]]|0.433| |[[:human genes:t:tbc1d3l|TBC1D3L]]|0.433| |[[:human genes:t:tbc1d3i|TBC1D3I]]|0.433| |[[:human genes:s:sf3a2|SF3A2]]|0.433| |[[:human genes:t:tbc1d3k|TBC1D3K]]|0.432| |[[:human genes:p:psmc6|PSMC6]]|0.432| |[[:human genes:p:pwp2|PWP2]]|0.432| |[[:human genes:p:psmb1|PSMB1]]|0.431| |[[:human genes:c:cdrt15|CDRT15]]|0.43| |[[:human genes:n:nop16|NOP16]]|0.43| |[[:human genes:z:znf541|ZNF541]]|0.429| |[[:human genes:s:syne3|SYNE3]]|0.428| |[[:human genes:s:sap30bp|SAP30BP]]|0.428| |[[:human genes:i:igfn1|IGFN1]]|0.428| |[[:human genes:g:golga8j|GOLGA8J]]|0.428| |[[:human genes:r:rad21|RAD21]]|0.427| |[[:human genes:g:gosr2|GOSR2]]|0.427| |[[:human genes:c:clcn6|CLCN6]]|0.427| |[[:human genes:f:fcn2|FCN2]]|0.426| |[[:human genes:d:dnttip2|DNTTIP2]]|0.426| |[[:human genes:r:rnf113a|RNF113A]]|0.425| |[[:human genes:s:sult1a3|SULT1A3]]|0.425| |[[:human genes:k:klhl1|KLHL1]]|0.425| |[[:human genes:s:smg1|SMG1]]|0.425| |[[:human genes:e:exd1|EXD1]]|0.424| |[[:human genes:s:sult1a4|SULT1A4]]|0.424| |[[:human genes:i:ik|IK]]|0.424| |[[:human genes:z:zfand5|ZFAND5]]|0.424| |[[:human genes:m:myt1l|MYT1L]]|0.423| |[[:human genes:c:cdca5|CDCA5]]|0.423| |[[:human genes:r:rnf121|RNF121]]|0.422| |[[:human genes:e:esyt1|ESYT1]]|0.421| |[[:human genes:r:rps9|RPS9]]|0.421| |[[:human genes:r:rrp12|RRP12]]|0.42| |[[:human genes:u:utp20|UTP20]]|0.419| |[[:human genes:z:znf574|ZNF574]]|0.419| |[[:human genes:g:golga6l4|GOLGA6L4]]|0.419| |[[:human genes:p:psmd1|PSMD1]]|0.419| |[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.418| |[[:human genes:e:eif3g|EIF3G]]|0.418| |[[:human genes:c:cdc6|CDC6]]|0.418| |[[:human genes:p:polr1a|POLR1A]]|0.418| |[[:human genes:c:c2orf27b|C2orf27B]]|0.417| |[[:human genes:s:snip1|SNIP1]]|0.417| |[[:human genes:a:ankle2|ANKLE2]]|0.417| |[[:human genes:t:taf1|TAF1]]|0.417| |[[:human genes:c:cdh24|CDH24]]|0.417| |[[:human genes:c:cmya5|CMYA5]]|0.417| |[[:human genes:m:med14|MED14]]|0.417| |[[:human genes:r:rpl34|RPL34]]|0.417| |[[:human genes:r:rad51|RAD51]]|0.417| |[[:human genes:e:egr2|EGR2]]|0.416| |[[:human genes:r:rilpl1|RILPL1]]|0.416| |[[:human genes:t:tagln|TAGLN]]|0.415| |[[:human genes:a:akt1s1|AKT1S1]]|0.415| |[[:human genes:c:ctr9|CTR9]]|0.415| |[[:human genes:d:dido1|DIDO1]]|0.415| |[[:human genes:k:krt78|KRT78]]|0.414| |[[:human genes:r:rilpl2|RILPL2]]|0.414| |[[:human genes:c:cln6|CLN6]]|0.414| |[[:human genes:f:fam231a|FAM231A]]|0.414| |[[:human genes:f:fam231c|FAM231C]]|0.413| |[[:human genes:p:plk4|PLK4]]|0.413| |[[:human genes:r:rfc1|RFC1]]|0.412| |[[:human genes:p:psmb3|PSMB3]]|0.412| |[[:human genes:t:trrap|TRRAP]]|0.411| |[[:human genes:c:ctage9|CTAGE9]]|0.411| |[[:human genes:a:angptl4|ANGPTL4]]|0.411| |[[:human genes:s:s1pr4|S1PR4]]|0.411| |[[:human genes:k:kin|KIN]]|0.411| |[[:human genes:p:plxnb3|PLXNB3]]|0.411| |[[:human genes:s:smtn|SMTN]]|0.41| |[[:human genes:g:golga8o|GOLGA8O]]|0.41| |[[:human genes:r:rps5|RPS5]]|0.409| |[[:human genes:p:pan2|PAN2]]|0.409| |[[:human genes:t:traip|TRAIP]]|0.409| |[[:human genes:a:aldh1b1|ALDH1B1]]|0.409| |[[:human genes:t:tbc1d3|TBC1D3]]|0.408| |[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.407| |[[:human genes:n:nipbl|NIPBL]]|0.407| |[[:human genes:c:cwc22|CWC22]]|0.407| |[[:human genes:n:nup214|NUP214]]|0.407| |[[:human genes:t:trappc2l|TRAPPC2L]]|0.407| |[[:human genes:e:exosc4|EXOSC4]]|0.406| |[[:human genes:c:chchd3|CHCHD3]]|0.406| |[[:human genes:a:atxn1|ATXN1]]|0.405| |[[:human genes:p:plekha4|PLEKHA4]]|0.405| |[[:human genes:i:ints6|INTS6]]|0.404| |[[:human genes:g:golga6a|GOLGA6A]]|0.404| |[[:human genes:t:tbc1d3c|TBC1D3C]]|0.404| |[[:human genes:r:rps7|RPS7]]|0.404| |[[:human genes:z:znf106|ZNF106]]|0.404| |[[:human genes:n:nup155|NUP155]]|0.403| |[[:human genes:s:scaf1|SCAF1]]|0.403| |[[:human genes:s:scgb1c1|SCGB1C1]]|0.403| |[[:human genes:s:sf3b5|SF3B5]]|0.402| |[[:human genes:r:rrm2|RRM2]]|0.4| |[[:human genes:p:psmd8|PSMD8]]|0.4| |[[:human genes:s:sart1|SART1]]|0.4| Global Fraction of Cell Lines Where Essential: 653/739 ^Tissue^Fraction Of Cell Lines Where Essential^ |1290807.0|1/1| |909776.0|1/1| |bile duct|24/28| |blood|25/28| |bone|22/26| |breast|29/33| |central nervous system|50/56| |cervix|1/4| |colorectal|15/17| |esophagus|13/13| |fibroblast|1/1| |gastric|16/16| |kidney|21/21| |liver|19/20| |lung|59/75| |lymphocyte|14/16| |ovary|25/26| |pancreas|21/24| |peripheral nervous system|10/16| |plasma cell|15/15| |prostate|1/1| |skin|20/24| |soft tissue|7/9| |thyroid|2/2| |upper aerodigestive|22/22| |urinary tract|28/29| |uterus|5/5| == Essentiality in NALM6 == * **Essentiality Rank**: 471 * **Expression level (log2 read counts)**: 6.79 {{:chemogenomics:nalm6 dist.png?nolink |}}