======= COQ4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COQ4
  * **<color #00a2e8>Official Name</color>**: coenzyme Q4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51117|51117]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y3A0|Q9Y3A0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COQ4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COQ4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612898|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a component of the coenzyme Q biosynthesis pathway. Coenzyme Q, an essential component of the electron transport chain, shuttles electrons between complexes I or II to complex III of the mitochondrial transport chain. This protein appears to play a structural role in stabilizing a complex that contains most of the coenzyme Q biosynthesis enzymes. Mutations in this gene are associated with mitochondrial disorders linked to coenzyme Q deficiency. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides. {ECO:0000255|HAMAP- Rule:MF_03111, ECO:0000269|PubMed:18474229}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Coq4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of mitochondrial inner membrane|
|quinone biosynthetic process|
|ubiquinone biosynthetic process|
|ubiquinone metabolic process|
|ketone biosynthetic process|
|quinone metabolic process|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|coenzyme biosynthetic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|cofactor metabolic process|
|small molecule biosynthetic process|
|protein-containing complex|
|mitochondrion|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp113|1-Methyl-nicotinamide-chloride 1000μM R03 exp113]]|-1.78|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.7|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.77|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.82|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.96|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.01|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.27|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coq2|COQ2]]|0.53|
|[[:human genes:m:mrpl21|MRPL21]]|0.502|
|[[:human genes:e:ears2|EARS2]]|0.494|
|[[:human genes:c:cox16|COX16]]|0.489|
|[[:human genes:f:fastkd5|FASTKD5]]|0.485|
|[[:human genes:c:coq5|COQ5]]|0.475|
|[[:human genes:n:ndufc2|NDUFC2]]|0.475|
|[[:human genes:p:pdss1|PDSS1]]|0.474|
|[[:human genes:m:mrp63|MRP63]]|0.474|
|[[:human genes:r:rpusd4|RPUSD4]]|0.473|
|[[:human genes:m:mrps34|MRPS34]]|0.471|
|[[:human genes:q:qrsl1|QRSL1]]|0.471|
|[[:human genes:m:mrpl53|MRPL53]]|0.47|
|[[:human genes:m:mrpl44|MRPL44]]|0.469|
|[[:human genes:n:ndufa2|NDUFA2]]|0.467|
|[[:human genes:p:pdss2|PDSS2]]|0.466|
|[[:human genes:m:mrps21|MRPS21]]|0.46|
|[[:human genes:g:gfm1|GFM1]]|0.459|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.458|
|[[:human genes:m:mrps5|MRPS5]]|0.457|
|[[:human genes:m:mrpl47|MRPL47]]|0.457|
|[[:human genes:t:tefm|TEFM]]|0.455|
|[[:human genes:l:lars2|LARS2]]|0.452|
|[[:human genes:s:sars2|SARS2]]|0.452|
|[[:human genes:c:cox6b1|COX6B1]]|0.448|
|[[:human genes:d:dap3|DAP3]]|0.446|
|[[:human genes:s:sco2|SCO2]]|0.446|
|[[:human genes:n:ndufa3|NDUFA3]]|0.445|
|[[:human genes:b:bcs1l|BCS1L]]|0.445|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.444|
|[[:human genes:m:mrpl18|MRPL18]]|0.442|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.442|
|[[:human genes:v:vars2|VARS2]]|0.441|
|[[:human genes:c:chchd1|CHCHD1]]|0.44|
|[[:human genes:f:ftsj2|FTSJ2]]|0.439|
|[[:human genes:m:mrpl23|MRPL23]]|0.437|
|[[:human genes:n:nars2|NARS2]]|0.436|
|[[:human genes:d:dars2|DARS2]]|0.434|
|[[:human genes:c:coq7|COQ7]]|0.433|
|[[:human genes:c:coq6|COQ6]]|0.433|
|[[:human genes:m:mrps6|MRPS6]]|0.433|
|[[:human genes:s:selrc1|SELRC1]]|0.432|
|[[:human genes:c:coa6|COA6]]|0.432|
|[[:human genes:f:fars2|FARS2]]|0.427|
|[[:human genes:m:mtg2|MTG2]]|0.427|
|[[:human genes:n:ndufa11|NDUFA11]]|0.426|
|[[:human genes:m:minos1|MINOS1]]|0.423|
|[[:human genes:m:mrpl1|MRPL1]]|0.422|
|[[:human genes:c:c12orf65|C12orf65]]|0.42|
|[[:human genes:m:mrps10|MRPS10]]|0.418|
|[[:human genes:m:mrpl45|MRPL45]]|0.418|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.416|
|[[:human genes:c:c10orf2|C10orf2]]|0.416|
|[[:human genes:c:cox11|COX11]]|0.415|
|[[:human genes:m:mrps35|MRPS35]]|0.413|
|[[:human genes:m:mrps14|MRPS14]]|0.413|
|[[:human genes:p:pet112|PET112]]|0.412|
|[[:human genes:m:mrps23|MRPS23]]|0.411|
|[[:human genes:p:pet100|PET100]]|0.41|
|[[:human genes:e:ecsit|ECSIT]]|0.409|
|[[:human genes:m:mrps16|MRPS16]]|0.408|
|[[:human genes:m:mrps9|MRPS9]]|0.407|
|[[:human genes:n:ndufb5|NDUFB5]]|0.407|
|[[:human genes:n:ndufb3|NDUFB3]]|0.406|
|[[:human genes:y:yars2|YARS2]]|0.405|
|[[:human genes:p:pet117|PET117]]|0.404|
|[[:human genes:n:ndufs7|NDUFS7]]|0.404|
|[[:human genes:n:ndufs2|NDUFS2]]|0.403|
|[[:human genes:m:mrps24|MRPS24]]|0.402|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.4|
|[[:human genes:c:coa3|COA3]]|0.4|
|[[:human genes:c:cox15|COX15]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 103/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|9/28|
|bone|3/26|
|breast|6/33|
|central nervous system|5/56|
|cervix|2/4|
|colorectal|3/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|3/21|
|liver|3/20|
|lung|13/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 884
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COQ4 Expression in NALM6 Cells: 5.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>