======= COQ6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COQ6
  * **<color #00a2e8>Official Name</color>**: coenzyme Q6, monooxygenase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51004|51004]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Z9|Q9Y2Z9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COQ6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COQ6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614647|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to the ubiH/COQ6 family. It is an evolutionarily conserved monooxygenase required for the biosynthesis of coenzyme Q10 (or ubiquinone), which is an essential component of the mitochondrial electron transport chain, and one of the most potent lipophilic antioxidants implicated in the protection of cell damage by reactive oxygen species. Knockdown of this gene in mouse and zebrafish results in decreased growth due to increased apoptosis. Mutations in this gene are associated with autosomal recessive coenzyme Q10 deficiency-6 (COQ10D6), which manifests as nephrotic syndrome with sensorineural deafness. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3- polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. {ECO:0000255|HAMAP-Rule:MF_03193}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|FAD binding 3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|
|extrinsic component of mitochondrial inner membrane|
|ubiquinone biosynthetic process|
|quinone biosynthetic process|
|ubiquinone metabolic process|
|ketone biosynthetic process|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|
|quinone metabolic process|
|FAD binding|
|oxidoreduction coenzyme metabolic process|
|cellular ketone metabolic process|
|cell projection|
|oxidoreductase activity|
|coenzyme biosynthetic process|
|cofactor biosynthetic process|
|coenzyme metabolic process|
|cofactor metabolic process|
|small molecule biosynthetic process|
|oxidation-reduction process|
|Golgi apparatus|
|mitochondrion|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp139|Nicotinamide Riboside 100μM R03 exp139]]|-1.96|
|[[:results:exp283|Glyphosate 1000μM R06 exp283]]|-1.92|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.71|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.77|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.79|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.8|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.85|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.97|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.03|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.2|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.28|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.39|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.5|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|3.03|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:coq3|COQ3]]|0.579|
|[[:human genes:c:coq2|COQ2]]|0.515|
|[[:human genes:g:gfm1|GFM1]]|0.501|
|[[:human genes:r:rpusd4|RPUSD4]]|0.483|
|[[:human genes:m:mrpl21|MRPL21]]|0.469|
|[[:human genes:u:uqcc2|UQCC2]]|0.467|
|[[:human genes:m:mrpl53|MRPL53]]|0.466|
|[[:human genes:c:coq7|COQ7]]|0.461|
|[[:human genes:p:pdss1|PDSS1]]|0.453|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.453|
|[[:human genes:o:opa1|OPA1]]|0.453|
|[[:human genes:y:yars2|YARS2]]|0.45|
|[[:human genes:m:mrps5|MRPS5]]|0.448|
|[[:human genes:p:polg2|POLG2]]|0.439|
|[[:human genes:c:coq5|COQ5]]|0.439|
|[[:human genes:n:nars2|NARS2]]|0.439|
|[[:human genes:c:c10orf2|C10orf2]]|0.435|
|[[:human genes:c:crls1|CRLS1]]|0.434|
|[[:human genes:c:coq4|COQ4]]|0.433|
|[[:human genes:m:mrpl23|MRPL23]]|0.43|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.428|
|[[:human genes:s:sco2|SCO2]]|0.427|
|[[:human genes:f:ftsj2|FTSJ2]]|0.425|
|[[:human genes:t:timm8b|TIMM8B]]|0.424|
|[[:human genes:m:mrp63|MRP63]]|0.423|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.419|
|[[:human genes:v:vars2|VARS2]]|0.419|
|[[:human genes:q:qrsl1|QRSL1]]|0.419|
|[[:human genes:m:mrps34|MRPS34]]|0.417|
|[[:human genes:m:mtif2|MTIF2]]|0.414|
|[[:human genes:d:dars2|DARS2]]|0.414|
|[[:human genes:g:gfm2|GFM2]]|0.413|
|[[:human genes:d:dap3|DAP3]]|0.412|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.412|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.412|
|[[:human genes:m:mrps24|MRPS24]]|0.411|
|[[:human genes:s:slc25a3|SLC25A3]]|0.41|
|[[:human genes:p:pars2|PARS2]]|0.408|
|[[:human genes:m:mrps6|MRPS6]]|0.407|
|[[:human genes:c:c12orf65|C12orf65]]|0.407|
|[[:human genes:s:selrc1|SELRC1]]|0.406|
|[[:human genes:p:pitrm1|PITRM1]]|0.405|
|[[:human genes:r:romo1|ROMO1]]|0.405|
|[[:human genes:b:bcs1l|BCS1L]]|0.404|
|[[:human genes:l:lars2|LARS2]]|0.404|
|[[:human genes:t:tufm|TUFM]]|0.403|
|[[:human genes:t:timm17a|TIMM17A]]|0.403|
|[[:human genes:t:tars2|TARS2]]|0.403|
|[[:human genes:m:mrps21|MRPS21]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1026
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.96 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COQ6 Expression in NALM6 Cells: 4.96'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>