======= COX7A2L =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: COX7A2L
  * **<color #00a2e8>Official Name</color>**: cytochrome c oxidase subunit 7A2 like
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9167|9167]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14548|O14548]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=COX7A2L&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20COX7A2L|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605771|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity). {ECO:0000250|UniProtKB:Q61387}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|COX7a|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respirasome assembly|
|mitochondrial respirasome|
|mitochondrial electron transport, cytochrome c to oxygen|
|aerobic electron transport chain|
|cytochrome-c oxidase activity|
|regulation of oxidative phosphorylation|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|respiratory electron transport chain|
|oxidative phosphorylation|
|regulation of ATP metabolic process|
|proton transmembrane transport|
|regulation of generation of precursor metabolites and energy|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|mitochondrial inner membrane|
|monovalent inorganic cation transport|
|generation of precursor metabolites and energy|
|mitochondrion organization|
|inorganic cation transmembrane transport|
|cation transmembrane transport|
|inorganic ion transmembrane transport|
|cation transport|
|cellular protein-containing complex assembly|
|nucleolus|
|ion transmembrane transport|
|oxidation-reduction process|
|mitochondrion|
|transmembrane transport|
|phosphorylation|
|ion transport|
|protein-containing complex assembly|
|regulation of phosphorylation|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp20|Etoposide 10μM R00 exp20]]|-3.39|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-3.1|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-3.09|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-3.06|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.89|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-2.54|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|-2.54|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.52|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|-2.46|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.42|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-2.38|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.24|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.22|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.18|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-2.17|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.15|
|[[:results:exp17|DABN 20μM R00 exp17]]|-2.14|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.02|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.99|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.99|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-1.97|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.89|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-1.84|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-1.76|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.75|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.71|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|1.91|
|[[:results:exp11|CCCP 1μM R00 exp11]]|2.79|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrs2|MRS2]]|0.622|
|[[:human genes:p:polr2j3|POLR2J3]]|0.564|
|[[:human genes:r:rpl35|RPL35]]|0.548|
|[[:human genes:u:utp3|UTP3]]|0.528|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.51|
|[[:human genes:r:rrp7a|RRP7A]]|0.506|
|[[:human genes:p:psmb4|PSMB4]]|0.504|
|[[:human genes:p:prpf3|PRPF3]]|0.502|
|[[:human genes:p:polr2f|POLR2F]]|0.491|
|[[:human genes:c:copg1|COPG1]]|0.485|
|[[:human genes:a:aatf|AATF]]|0.485|
|[[:human genes:s:slc25a36|SLC25A36]]|0.484|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.483|
|[[:human genes:v:vps28|VPS28]]|0.473|
|[[:human genes:p:psmb2|PSMB2]]|0.469|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.469|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.468|
|[[:human genes:p:prim1|PRIM1]]|0.465|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.464|
|[[:human genes:c:cdca5|CDCA5]]|0.456|
|[[:human genes:n:nfatc4|NFATC4]]|0.454|
|[[:human genes:e:eftud2|EFTUD2]]|0.454|
|[[:human genes:r:rpl9|RPL9]]|0.453|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.452|
|[[:human genes:o:or4f17|OR4F17]]|0.452|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.451|
|[[:human genes:c:cnot3|CNOT3]]|0.45|
|[[:human genes:t:tceb3c|TCEB3C]]|0.45|
|[[:human genes:s:slc25a33|SLC25A33]]|0.448|
|[[:human genes:b:brd2|BRD2]]|0.442|
|[[:human genes:n:nme6|NME6]]|0.442|
|[[:human genes:a:aamp|AAMP]]|0.44|
|[[:human genes:n:nol9|NOL9]]|0.437|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.437|
|[[:human genes:k:kctd17|KCTD17]]|0.435|
|[[:human genes:t:tspy8|TSPY8]]|0.435|
|[[:human genes:c:chd4|CHD4]]|0.435|
|[[:human genes:n:npipb5|NPIPB5]]|0.435|
|[[:human genes:c:cdh24|CDH24]]|0.433|
|[[:human genes:t:taf1|TAF1]]|0.431|
|[[:human genes:t:tsg101|TSG101]]|0.43|
|[[:human genes:t:tspy2|TSPY2]]|0.429|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.427|
|[[:human genes:c:col2a1|COL2A1]]|0.427|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.426|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.426|
|[[:human genes:c:cep192|CEP192]]|0.424|
|[[:human genes:p:pole|POLE]]|0.424|
|[[:human genes:i:igfn1|IGFN1]]|0.423|
|[[:human genes:s:slc4a1|SLC4A1]]|0.422|
|[[:human genes:f:fam25b|FAM25B]]|0.422|
|[[:human genes:r:rps7|RPS7]]|0.421|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.42|
|[[:human genes:n:ncapg|NCAPG]]|0.417|
|[[:human genes:p:psmb1|PSMB1]]|0.416|
|[[:human genes:s:sart1|SART1]]|0.415|
|[[:human genes:p:pan3|PAN3]]|0.414|
|[[:human genes:p:polr2l|POLR2L]]|0.414|
|[[:human genes:c:c14orf93|C14orf93]]|0.411|
|[[:human genes:e:exosc8|EXOSC8]]|0.41|
|[[:human genes:e:exosc7|EXOSC7]]|0.409|
|[[:human genes:s:supt5h|SUPT5H]]|0.409|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.408|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.408|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.408|
|[[:human genes:m:myb|MYB]]|0.408|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.407|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.407|
|[[:human genes:a:akt1s1|AKT1S1]]|0.406|
|[[:human genes:s:sf3a1|SF3A1]]|0.405|
|[[:human genes:d:dtl|DTL]]|0.405|
|[[:human genes:u:usp35|USP35]]|0.404|
|[[:human genes:t:tyms|TYMS]]|0.404|
|[[:human genes:s:snrpa1|SNRPA1]]|0.403|
|[[:human genes:p:polr2i|POLR2I]]|0.403|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.403|
|[[:human genes:z:znf574|ZNF574]]|0.403|
|[[:human genes:x:xab2|XAB2]]|0.402|
|[[:human genes:p:psma7|PSMA7]]|0.401|
|[[:human genes:t:twistnb|TWISTNB]]|0.401|
|[[:human genes:m:myh7b|MYH7B]]|0.401|
|[[:human genes:t:trappc11|TRAPPC11]]|0.401|
|[[:human genes:t:tonsl|TONSL]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 19084
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='COX7A2L Expression in NALM6 Cells: 5.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>