======= CPLX1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CPLX1
  * **<color #00a2e8>Official Name</color>**: complexin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10815|10815]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14810|O14810]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CPLX1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CPLX1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605032|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:21785414). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:21785414). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. {ECO:0000250|UniProtKB:P63040, ECO:0000269|PubMed:21785414}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Synaphin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex|
|synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex|
|exocytic insertion of neurotransmitter receptor to postsynaptic membrane|
|neurotransmitter transmembrane transporter activity|
|regulation of synaptic vesicle fusion to presynaptic active zone membrane|
|neurotransmitter receptor transport to plasma membrane|
|neurotransmitter receptor transport to postsynaptic membrane|
|establishment of protein localization to postsynaptic membrane|
|calyx of Held|
|syntaxin-1 binding|
|glutamate secretion|
|regulation of vesicle fusion|
|neurotransmitter receptor transport|
|protein localization to postsynaptic membrane|
|insulin secretion|
|receptor localization to synapse|
|acidic amino acid transport|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|SNARE complex|
|terminal bouton|
|peptide hormone secretion|
|protein localization to synapse|
|synaptic vesicle exocytosis|
|SNARE binding|
|hormone secretion|
|regulation of synaptic vesicle exocytosis|
|dicarboxylic acid transport|
|acid secretion|
|hormone transport|
|Schaffer collateral - CA1 synapse|
|postsynapse|
|vesicle-mediated transport to the plasma membrane|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of neurotransmitter secretion|
|regulation of synaptic vesicle cycle|
|amino acid transport|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|protein secretion|
|establishment of protein localization to extracellular region|
|regulation of regulated secretory pathway|
|protein localization to extracellular region|
|signal release|
|peptide secretion|
|neurotransmitter transport|
|regulation of exocytosis|
|protein localization to cell periphery|
|protein-containing complex localization|
|establishment of protein localization to membrane|
|organic acid transport|
|carboxylic acid transport|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|neuronal cell body|
|chemical synaptic transmission|
|dendrite|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|organic anion transport|
|synaptic signaling|
|protein localization to membrane|
|regulation of hormone levels|
|regulation of vesicle-mediated transport|
|anion transport|
|regulated exocytosis|
|regulation of secretion by cell|
|exocytosis|
|regulation of secretion|
|regulation of cellular localization|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|regulation of organelle organization|
|ion transport|
|protein transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.28|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-1.97|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.78|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13403
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CPLX1 Expression in NALM6 Cells: -4.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>