======= CRH =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRH
  * **<color #00a2e8>Official Name</color>**: corticotropin releasing hormone
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1392|1392]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06850|P06850]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRH&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRH|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/122560|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). {ECO:0000250|UniProtKB:P06296, ECO:0000250|UniProtKB:Q8CIT0}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CRF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corticotropin-releasing hormone activity|
|positive regulation of corticosterone secretion|
|negative regulation of circadian sleep/wake cycle, REM sleep|
|cellular response to cocaine|
|negative regulation of luteinizing hormone secretion|
|positive regulation of circadian sleep/wake cycle, wakefulness|
|regulation of circadian sleep/wake cycle, wakefulness|
|regulation of circadian sleep/wake cycle, REM sleep|
|regulation of corticosterone secretion|
|corticotropin-releasing hormone receptor 2 binding|
|corticotropin-releasing hormone receptor 1 binding|
|negative regulation of circadian sleep/wake cycle, sleep|
|negative regulation of glucagon secretion|
|hormone-mediated apoptotic signaling pathway|
|positive regulation of cortisol secretion|
|positive regulation of corticotropin secretion|
|regulation of corticotropin secretion|
|positive regulation of glucocorticoid secretion|
|negative regulation of epinephrine secretion|
|regulation of cortisol secretion|
|regulation of luteinizing hormone secretion|
|positive regulation of fear response|
|regulation of serotonin secretion|
|positive regulation of behavioral fear response|
|negative regulation of gonadotropin secretion|
|positive regulation of corticosteroid hormone secretion|
|varicosity|
|regulation of epinephrine secretion|
|negative regulation of norepinephrine secretion|
|regulation of glucagon secretion|
|regulation of fear response|
|regulation of behavioral fear response|
|positive regulation of digestive system process|
|positive regulation of steroid hormone secretion|
|regulation of glucocorticoid secretion|
|regulation of gonadotropin secretion|
|glucocorticoid biosynthetic process|
|response to ether|
|locomotory exploration behavior|
|negative regulation of circadian rhythm|
|negative regulation of catecholamine secretion|
|parturition|
|glucocorticoid metabolic process|
|regulation of norepinephrine secretion|
|regulation of corticosteroid hormone secretion|
|regulation of circadian sleep/wake cycle, sleep|
|positive regulation of circadian rhythm|
|negative regulation of behavior|
|negative regulation of systemic arterial blood pressure|
|regulation of steroid hormone secretion|
|synaptic transmission, dopaminergic|
|positive regulation of calcium ion import|
|regulation of circadian sleep/wake cycle|
|response to corticosterone|
|hypothalamus development|
|positive regulation of cAMP-mediated signaling|
|adrenal gland development|
|negative regulation of amine transport|
|exploration behavior|
|response to immobilization stress|
|neuropeptide hormone activity|
|positive regulation of behavior|
|cellular response to dexamethasone stimulus|
|response to pain|
|positive regulation of response to drug|
|response to mineralocorticoid|
|positive regulation of insulin secretion involved in cellular response to glucose stimulus|
|cellular response to alkaloid|
|regulation of NMDA receptor activity|
|regulation of calcium ion import|
|regulation of digestive system process|
|response to dexamethasone|
|regulation of endocrine process|
|negative regulation of peptide hormone secretion|
|negative regulation of blood pressure|
|steroid hormone biosynthetic process|
|long-term synaptic potentiation|
|regulation of cAMP-mediated signaling|
|response to cocaine|
|cellular response to glucocorticoid stimulus|
|regulation of insulin secretion involved in cellular response to glucose stimulus|
|cellular response to corticosteroid stimulus|
|hormone biosynthetic process|
|positive regulation of lipid transport|
|regulation of catecholamine secretion|
|negative regulation of hormone secretion|
|regulation of glutamate receptor signaling pathway|
|multicellular organismal response to stress|
|regulation of behavior|
|positive regulation of insulin secretion|
|regulation of neurotransmitter receptor activity|
|diencephalon development|
|response to estrogen|
|associative learning|
|response to anesthetic|
|positive regulation of lipid localization|
|cellular response to ketone|
|regulation of systemic arterial blood pressure|
|regulation of amine transport|
|response to antineoplastic agent|
|positive regulation of peptide hormone secretion|
|hormone activity|
|regulation of response to drug|
|regulation of lipid transport|
|diterpenoid metabolic process|
|limbic system development|
|response to alkaloid|
|regulation of circadian rhythm|
|terpenoid metabolic process|
|endocrine system development|
|positive regulation of calcium ion transport|
|response to ethanol|
|steroid biosynthetic process|
|positive regulation of hormone secretion|
|cellular response to ammonium ion|
|perikaryon|
|regulation of lipid localization|
|isoprenoid metabolic process|
|negative regulation of peptide secretion|
|regulation of neurotransmitter transport|
|response to glucocorticoid|
|learning|
|positive regulation of synaptic transmission|
|response to corticosteroid|
|lung development|
|hormone-mediated signaling pathway|
|regulation of cation channel activity|
|respiratory tube development|
|regulation of signaling receptor activity|
|regulation of insulin secretion|
|female pregnancy|
|regulation of blood pressure|
|response to ammonium ion|
|cellular response to xenobiotic stimulus|
|cellular response to steroid hormone stimulus|
|regulation of synaptic plasticity|
|response to ketone|
|locomotory behavior|
|respiratory system development|
|hormone metabolic process|
|negative regulation of secretion by cell|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|negative regulation of secretion|
|response to alcohol|
|regulation of calcium ion transport|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|steroid metabolic process|
|regulation of transmembrane transporter activity|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of ion transport|
|regulation of transporter activity|
|apoptotic signaling pathway|
|positive regulation of peptide secretion|
|cognition|
|response to xenobiotic stimulus|
|response to antibiotic|
|response to steroid hormone|
|regulation of cation transmembrane transport|
|signaling receptor binding|
|regulation of metal ion transport|
|forebrain development|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|cellular response to drug|
|gland development|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|positive regulation of protein transport|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of establishment of protein localization|
|synaptic signaling|
|regulation of protein secretion|
|positive regulation of defense response|
|regulation of ion transmembrane transport|
|negative regulation of transport|
|regulation of peptide secretion|
|inflammatory response|
|response to toxic substance|
|cellular response to lipid|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|regulation of transmembrane transport|
|behavior|
|lipid biosynthetic process|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|positive regulation of cell death|
|regulation of ion transport|
|regulation of protein transport|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|head development|
|ion homeostasis|
|regulation of secretion|
|tube development|
|response to lipid|
|response to hormone|
|positive regulation of cell population proliferation|
|regulation of cellular localization|
|response to organic cyclic compound|
|apoptotic process|
|cellular lipid metabolic process|
|central nervous system development|
|positive regulation of transport|
|multi-organism reproductive process|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|response to drug|
|regulation of protein localization|
|programmed cell death|
|cellular response to oxygen-containing compound|
|positive regulation of phosphorylation|
|response to nitrogen compound|
|cell death|
|chemical homeostasis|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|organic cyclic compound biosynthetic process|
|G protein-coupled receptor signaling pathway|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|response to oxygen-containing compound|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|extracellular region|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5349
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -6.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRH Expression in NALM6 Cells: -6.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>