======= CRLS1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CRLS1
  * **<color #00a2e8>Official Name</color>**: cardiolipin synthase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54675|54675]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UJA2|Q9UJA2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CRLS1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CRLS1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608188|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. {ECO:0000269|PubMed:16547353, ECO:0000269|PubMed:16678169}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CDP-OH P transf|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity|
|response to phosphatidylethanolamine|
|cardiolipin synthase activity|
|2-acylglycerol-3-phosphate O-acyltransferase activity|
|response to L-phenylalanine derivative|
|response to thyroxine|
|cardiolipin biosynthetic process|
|phosphatidylglycerol biosynthetic process|
|cardiolipin metabolic process|
|1-acylglycerol-3-phosphate O-acyltransferase activity|
|phosphatidylglycerol acyl-chain remodeling|
|response to thyroid hormone|
|phosphatidylglycerol metabolic process|
|response to amino acid|
|response to organophosphorus|
|glycerophospholipid biosynthetic process|
|glycerolipid biosynthetic process|
|phospholipid biosynthetic process|
|glycerophospholipid metabolic process|
|response to acid chemical|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|mitochondrial inner membrane|
|organophosphate biosynthetic process|
|lipid biosynthetic process|
|response to lipid|
|organophosphate metabolic process|
|response to hormone|
|response to organic cyclic compound|
|cellular lipid metabolic process|
|response to organonitrogen compound|
|response to drug|
|response to nitrogen compound|
|lipid metabolic process|
|mitochondrion|
|response to endogenous stimulus|
|response to oxygen-containing compound|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.82|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|1.7|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|1.72|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.72|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|1.74|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.77|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.81|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.83|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|1.83|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.9|
|[[:results:exp467|CAY10603 0.55μM R08 exp467]]|1.91|
|[[:results:exp26|Oligomycin-A 20μM R00 exp26]]|1.92|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.94|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|1.95|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.96|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.98|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|2|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.02|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.02|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.03|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.05|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.06|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|2.08|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.15|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.2|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.25|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.27|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|2.27|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.27|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.33|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.34|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.35|
|[[:results:exp539|42°C R08 exp539]]|2.37|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|2.4|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.44|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|2.45|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|2.48|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.5|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|2.52|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.53|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.54|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|2.57|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.7|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.75|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.85|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.89|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|2.9|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.04|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:triap1|TRIAP1]]|0.717|
|[[:human genes:t:taz|TAZ]]|0.715|
|[[:human genes:r:romo1|ROMO1]]|0.712|
|[[:human genes:o:opa1|OPA1]]|0.657|
|[[:human genes:t:tamm41|TAMM41]]|0.62|
|[[:human genes:p:pmm2|PMM2]]|0.613|
|[[:human genes:s:slc25a26|SLC25A26]]|0.612|
|[[:human genes:t:timm13|TIMM13]]|0.607|
|[[:human genes:r:rpe|RPE]]|0.584|
|[[:human genes:d:dnlz|DNLZ]]|0.583|
|[[:human genes:s:srp14|SRP14]]|0.576|
|[[:human genes:h:hccs|HCCS]]|0.562|
|[[:human genes:a:apaf1|APAF1]]|0.56|
|[[:human genes:c:cycs|CYCS]]|0.557|
|[[:human genes:h:hars|HARS]]|0.557|
|[[:human genes:p:parl|PARL]]|0.537|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.524|
|[[:human genes:d:dpagt1|DPAGT1]]|0.52|
|[[:human genes:u:uap1|UAP1]]|0.513|
|[[:human genes:d:dohh|DOHH]]|0.509|
|[[:human genes:a:alg5|ALG5]]|0.508|
|[[:human genes:b:bak1|BAK1]]|0.505|
|[[:human genes:t:timm8b|TIMM8B]]|0.502|
|[[:human genes:t:thg1l|THG1L]]|0.498|
|[[:human genes:m:mrps14|MRPS14]]|0.496|
|[[:human genes:m:mrps6|MRPS6]]|0.496|
|[[:human genes:a:alg1|ALG1]]|0.491|
|[[:human genes:u:ube2g2|UBE2G2]]|0.49|
|[[:human genes:d:dap3|DAP3]]|0.489|
|[[:human genes:t:timm17a|TIMM17A]]|0.489|
|[[:human genes:c:casp9|CASP9]]|0.488|
|[[:human genes:t:trmt10a|TRMT10A]]|0.484|
|[[:human genes:r:rptor|RPTOR]]|0.483|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.482|
|[[:human genes:c:coq5|COQ5]]|0.48|
|[[:human genes:e:eno1|ENO1]]|0.479|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.478|
|[[:human genes:m:mrpl21|MRPL21]]|0.477|
|[[:human genes:a:alg6|ALG6]]|0.475|
|[[:human genes:m:mrps18a|MRPS18A]]|0.474|
|[[:human genes:h:hspd1|HSPD1]]|0.473|
|[[:human genes:p:pdss1|PDSS1]]|0.472|
|[[:human genes:g:gfpt1|GFPT1]]|0.472|
|[[:human genes:t:timm23b|TIMM23B]]|0.471|
|[[:human genes:t:tkt|TKT]]|0.471|
|[[:human genes:b:bap1|BAP1]]|0.468|
|[[:human genes:v:vdac2|VDAC2]]|0.468|
|[[:human genes:c:coq3|COQ3]]|0.467|
|[[:human genes:r:rpusd4|RPUSD4]]|0.464|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.463|
|[[:human genes:a:atp2a2|ATP2A2]]|0.459|
|[[:human genes:m:mrps16|MRPS16]]|0.459|
|[[:human genes:c:cbfb|CBFB]]|0.458|
|[[:human genes:t:tpi1|TPI1]]|0.458|
|[[:human genes:p:pnpt1|PNPT1]]|0.456|
|[[:human genes:f:fam210a|FAM210A]]|0.455|
|[[:human genes:p:plaa|PLAA]]|0.455|
|[[:human genes:m:mrpl23|MRPL23]]|0.453|
|[[:human genes:s:sec62|SEC62]]|0.453|
|[[:human genes:s:serf2|SERF2]]|0.451|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.448|
|[[:human genes:m:mfn1|MFN1]]|0.446|
|[[:human genes:p:pisd|PISD]]|0.446|
|[[:human genes:a:atp5j|ATP5J]]|0.445|
|[[:human genes:g:gmppb|GMPPB]]|0.445|
|[[:human genes:p:pgm3|PGM3]]|0.444|
|[[:human genes:z:zfp91|ZFP91]]|0.441|
|[[:human genes:p:pam16|PAM16]]|0.44|
|[[:human genes:m:mrps9|MRPS9]]|0.44|
|[[:human genes:a:atp5a1|ATP5A1]]|0.44|
|[[:human genes:m:mrps33|MRPS33]]|0.439|
|[[:human genes:m:mrps34|MRPS34]]|0.438|
|[[:human genes:p:ppa2|PPA2]]|0.438|
|[[:human genes:m:meaf6|MEAF6]]|0.437|
|[[:human genes:m:mrpl47|MRPL47]]|0.436|
|[[:human genes:h:hars2|HARS2]]|0.436|
|[[:human genes:g:gpi|GPI]]|0.436|
|[[:human genes:d:dars2|DARS2]]|0.435|
|[[:human genes:g:gfm1|GFM1]]|0.435|
|[[:human genes:c:coq6|COQ6]]|0.434|
|[[:human genes:v:vars2|VARS2]]|0.434|
|[[:human genes:a:atxn10|ATXN10]]|0.434|
|[[:human genes:m:mrps5|MRPS5]]|0.434|
|[[:human genes:p:ppcs|PPCS]]|0.434|
|[[:human genes:y:yars2|YARS2]]|0.433|
|[[:human genes:m:mrp63|MRP63]]|0.433|
|[[:human genes:c:cox16|COX16]]|0.432|
|[[:human genes:w:wbscr16|WBSCR16]]|0.429|
|[[:human genes:p:pars2|PARS2]]|0.429|
|[[:human genes:k:kdsr|KDSR]]|0.428|
|[[:human genes:w:wdr24|WDR24]]|0.428|
|[[:human genes:t:tmem41b|TMEM41B]]|0.427|
|[[:human genes:u:ube2k|UBE2K]]|0.427|
|[[:human genes:t:thoc6|THOC6]]|0.427|
|[[:human genes:e:eny2|ENY2]]|0.427|
|[[:human genes:b:brwd1|BRWD1]]|0.426|
|[[:human genes:s:slmo2|SLMO2]]|0.426|
|[[:human genes:t:trnt1|TRNT1]]|0.425|
|[[:human genes:d:dhrsx|DHRSX]]|0.425|
|[[:human genes:a:atp5b|ATP5B]]|0.423|
|[[:human genes:g:gfer|GFER]]|0.422|
|[[:human genes:v:vmp1|VMP1]]|0.422|
|[[:human genes:r:rnmt|RNMT]]|0.422|
|[[:human genes:b:bcs1l|BCS1L]]|0.421|
|[[:human genes:t:tbca|TBCA]]|0.42|
|[[:human genes:e:elf2|ELF2]]|0.419|
|[[:human genes:m:mtor|MTOR]]|0.418|
|[[:human genes:p:pggt1b|PGGT1B]]|0.418|
|[[:human genes:t:tufm|TUFM]]|0.418|
|[[:human genes:u:uhrf1|UHRF1]]|0.418|
|[[:human genes:m:mrpl15|MRPL15]]|0.417|
|[[:human genes:a:alg13|ALG13]]|0.417|
|[[:human genes:d:dhps|DHPS]]|0.417|
|[[:human genes:s:srd5a3|SRD5A3]]|0.417|
|[[:human genes:u:ube2m|UBE2M]]|0.416|
|[[:human genes:m:mrpl36|MRPL36]]|0.416|
|[[:human genes:m:mrpl53|MRPL53]]|0.415|
|[[:human genes:u:ube2j1|UBE2J1]]|0.415|
|[[:human genes:d:dad1|DAD1]]|0.415|
|[[:human genes:d:dhx30|DHX30]]|0.415|
|[[:human genes:a:atp5c1|ATP5C1]]|0.413|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.413|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.413|
|[[:human genes:s:sars2|SARS2]]|0.413|
|[[:human genes:c:csnk2b|CSNK2B]]|0.412|
|[[:human genes:a:atp5d|ATP5D]]|0.412|
|[[:human genes:r:rpia|RPIA]]|0.412|
|[[:human genes:n:nae1|NAE1]]|0.409|
|[[:human genes:u:utp23|UTP23]]|0.409|
|[[:human genes:d:diablo|DIABLO]]|0.409|
|[[:human genes:p:pgls|PGLS]]|0.407|
|[[:human genes:p:pgs1|PGS1]]|0.406|
|[[:human genes:r:rbfa|RBFA]]|0.406|
|[[:human genes:s:suv420h1|SUV420H1]]|0.406|
|[[:human genes:a:aars|AARS]]|0.405|
|[[:human genes:l:lsm10|LSM10]]|0.405|
|[[:human genes:a:atp5o|ATP5O]]|0.404|
|[[:human genes:r:rtcb|RTCB]]|0.404|
|[[:human genes:p:pgp|PGP]]|0.404|
|[[:human genes:n:nsd1|NSD1]]|0.404|
|[[:human genes:t:timm44|TIMM44]]|0.403|
|[[:human genes:t:timm8a|TIMM8A]]|0.402|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.401|
|[[:human genes:e:exoc4|EXOC4]]|0.401|
|[[:human genes:e:eif3f|EIF3F]]|0.4|
|[[:human genes:s:selrc1|SELRC1]]|0.4|
|[[:human genes:c:chchd4|CHCHD4]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 98/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|3/28|
|bone|4/26|
|breast|6/33|
|central nervous system|8/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|2/16|
|kidney|3/21|
|liver|3/20|
|lung|11/75|
|lymphocyte|4/16|
|ovary|1/26|
|pancreas|6/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|3/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 322
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.61 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CRLS1 Expression in NALM6 Cells: 5.61'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>