======= CSF1R =======
== Gene Information ==
* **Official Symbol**: CSF1R
* **Official Name**: colony stimulating factor 1 receptor
* **Aliases and Previous Symbols**: N/A
* **Entrez ID**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1436|1436]]
* **UniProt**: [[https://www.uniprot.org/uniprot/P07333|P07333]]
* **Interactions**: [[https://thebiogrid.org/search.php?search=CSF1R&organism=9606|BioGRID]]
* **PubMed articles**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSF1R|Open PubMed]]
* **OMIM**: [[https://omim.org/entry/164770|Open OMIM]]
== Function Summary ==
* **Entrez Summary**: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma. [provided by RefSeq, Mar 2017].
* **UniProt Summary**: Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP- 1. Receptor signaling is down-regulated by protein phosphatases, such as INPP5D/SHIP-1, that dephosphorylate the receptor and its downstream effectors, and by rapid internalization of the activated receptor. {ECO:0000269|PubMed:12882960, ECO:0000269|PubMed:15117969, ECO:0000269|PubMed:16170366, ECO:0000269|PubMed:16337366, ECO:0000269|PubMed:16648572, ECO:0000269|PubMed:17121910, ECO:0000269|PubMed:18467591, ECO:0000269|PubMed:18814279, ECO:0000269|PubMed:19193011, ECO:0000269|PubMed:19934330, ECO:0000269|PubMed:20489731, ECO:0000269|PubMed:20504948, ECO:0000269|PubMed:20829061, ECO:0000269|PubMed:7683918}.
|ig|
|Pkinase Tyr|
|Pkinase|
|CSF1-CSF1R complex|
|macrophage colony-stimulating factor receptor activity|
|macrophage colony-stimulating factor signaling pathway|
|macrophage proliferation|
|microglial cell proliferation|
|cellular response to macrophage colony-stimulating factor stimulus|
|response to macrophage colony-stimulating factor|
|cell-cell junction maintenance|
|cell junction maintenance|
|positive regulation of chemokine secretion|
|glial cell proliferation|
|regulation of chemokine secretion|
|positive regulation by host of viral process|
|mononuclear cell differentiation|
|monocyte differentiation|
|ruffle organization|
|macrophage differentiation|
|modulation by host of viral process|
|mammary gland duct morphogenesis|
|olfactory bulb development|
|olfactory lobe development|
|regulation of actin cytoskeleton reorganization|
|cytokine binding|
|regulation of bone resorption|
|mammary gland morphogenesis|
|osteoclast differentiation|
|cellular component maintenance|
|regulation of bone remodeling|
|response to ischemia|
|forebrain neuron differentiation|
|transmembrane receptor protein tyrosine kinase activity|
|positive regulation of protein tyrosine kinase activity|
|positive regulation of chemokine production|
|mammary gland epithelium development|
|forebrain generation of neurons|
|positive regulation of tyrosine phosphorylation of STAT protein|
|modification by host of symbiont morphology or physiology|
|phosphatidylinositol-mediated signaling|
|regulation of tissue remodeling|
|inositol lipid-mediated signaling|
|interaction with symbiont|
|regulation of chemokine production|
|regulation of tyrosine phosphorylation of STAT protein|
|positive regulation of receptor signaling pathway via JAK-STAT|
|protein phosphatase binding|
|hematopoietic progenitor cell differentiation|
|protein tyrosine kinase activity|
|positive regulation of receptor signaling pathway via STAT|
|regulation of protein tyrosine kinase activity|
|leukocyte proliferation|
|gland morphogenesis|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|myeloid leukocyte differentiation|
|mammary gland development|
|regulation of receptor signaling pathway via JAK-STAT|
|regulation of receptor signaling pathway via STAT|
|cell-cell junction organization|
|positive regulation of cytokine secretion|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|regulation of cell shape|
|modification of morphology or physiology of other organism|
|phosphatidylinositol metabolic process|
|central nervous system neuron differentiation|
|positive regulation of peptidyl-tyrosine phosphorylation|
|protein autophosphorylation|
|receptor complex|
|regulation of cytokine secretion|
|regulation of viral process|
|positive regulation of ERK1 and ERK2 cascade|
|gliogenesis|
|cell junction organization|
|myeloid cell differentiation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of peptidyl-tyrosine phosphorylation|
|telencephalon development|
|axon guidance|
|neuron projection guidance|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|regulation of ERK1 and ERK2 cascade|
|epithelial tube morphogenesis|
|glycerophospholipid metabolic process|
|leukocyte differentiation|
|positive regulation of protein serine/threonine kinase activity|
|regulation of actin cytoskeleton organization|
|axonogenesis|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|forebrain development|
|regulation of actin filament-based process|
|positive regulation of secretion by cell|
|axon development|
|gland development|
|positive regulation of protein transport|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|positive regulation of secretion|
|positive regulation of cytokine production|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of cell morphogenesis|
|regulation of peptide secretion|
|inflammatory response|
|positive regulation of cell migration|
|positive regulation of multi-organism process|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cell motility|
|positive regulation of protein kinase activity|
|positive regulation of cellular component movement|
|regulation of cytoskeleton organization|
|positive regulation of MAPK cascade|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|cell population proliferation|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|tissue morphogenesis|
|positive regulation of kinase activity|
|hematopoietic or lymphoid organ development|
|cell surface|
|immune system development|
|tube morphogenesis|
|positive regulation of transferase activity|
|neuron projection development|
|cytokine-mediated signaling pathway|
|negative regulation of cell population proliferation|
|intracellular membrane-bounded organelle|
|regulation of cytokine production|
|regulation of protein transport|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|regulation of peptide transport|
|brain development|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|innate immune response|
|regulation of multi-organism process|
|head development|
|symbiotic process|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|tube development|
|regulation of cell migration|
|regulation of kinase activity|
|protein homodimerization activity|
|peptidyl-amino acid modification|
|organophosphate metabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|defense response to other organism|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|regulation of locomotion|
|positive regulation of transport|
|negative regulation of cell death|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|regulation of protein localization|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|response to cytokine|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|lipid metabolic process|
|positive regulation of protein modification process|
|phosphorylation|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|defense response|
|integral component of plasma membrane|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|ATP binding|
|generation of neurons|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|immune response|
\\
=== CRISPR Data ===
No hits were found.
No correlation found to any other genes in chemogenomics.
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
== Essentiality in NALM6 ==
* **Essentiality Rank**: 16566
* **Expression level (log2 read counts)**: -0.1
{{:chemogenomics:nalm6 dist.png?nolink |}}