======= CSRP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CSRP3
  * **<color #00a2e8>Official Name</color>**: cysteine and glycine rich protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8048|8048]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50461|P50461]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CSRP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CSRP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600824|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Positive regulator of myogenesis. Acts as cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (By similarity). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly: Shown to enhance CFL2-mediated F-actin depolymerization dependent on the CSRP3:CFL2 molecular ratio, and also shown to reduce the ability of CLF1 and CFL2 to enhance actin depolymerization (PubMed:19752190, PubMed:24934443). Proposed to contribute to the maintenance of muscle cell integerity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (PubMed:24934443). In vitro can inhibit PKC/PRKCA activity (PubMed:27353086). Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000250|UniProtKB:P50463, ECO:0000269|PubMed:19752190, ECO:0000269|PubMed:24934443, ECO:0000269|PubMed:27353086}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|LIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|detection of muscle stretch|
|telethonin binding|
|T-tubule organization|
|actinin binding|
|protein kinase C signaling|
|response to muscle stretch|
|cardiac myofibril assembly|
|regulation of the force of heart contraction|
|cardiac muscle hypertrophy|
|striated muscle hypertrophy|
|muscle hypertrophy|
|detection of mechanical stimulus|
|sarcomere organization|
|structural constituent of muscle|
|cardiac muscle cell development|
|cardiac cell development|
|myofibril assembly|
|cardiac muscle contraction|
|heart contraction|
|cardiac muscle cell differentiation|
|insulin receptor signaling pathway|
|plasma membrane organization|
|regulation of protein localization to plasma membrane|
|heart process|
|cellular component assembly involved in morphogenesis|
|striated muscle contraction|
|regulation of protein localization to cell periphery|
|actomyosin structure organization|
|cardiocyte differentiation|
|detection of external stimulus|
|detection of abiotic stimulus|
|skeletal muscle tissue development|
|Z disc|
|skeletal muscle organ development|
|striated muscle cell development|
|muscle cell development|
|cardiac muscle tissue development|
|cellular response to insulin stimulus|
|glucose homeostasis|
|carbohydrate homeostasis|
|regulation of protein localization to membrane|
|striated muscle cell differentiation|
|response to mechanical stimulus|
|response to insulin|
|regulation of heart contraction|
|muscle cell differentiation|
|muscle contraction|
|cellular response to peptide hormone stimulus|
|actin binding|
|striated muscle tissue development|
|regulation of blood circulation|
|muscle organ development|
|muscle tissue development|
|muscle system process|
|cellular response to peptide|
|cytoskeleton|
|blood circulation|
|response to peptide hormone|
|circulatory system process|
|endomembrane system organization|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|supramolecular fiber organization|
|cellular divalent inorganic cation homeostasis|
|response to peptide|
|muscle structure development|
|divalent inorganic cation homeostasis|
|actin cytoskeleton organization|
|inflammatory response|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|heart development|
|regulation of cellular protein localization|
|cellular metal ion homeostasis|
|actin filament-based process|
|regulation of system process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cellular response to nitrogen compound|
|detection of stimulus|
|cation homeostasis|
|enzyme linked receptor protein signaling pathway|
|inorganic ion homeostasis|
|protein localization to organelle|
|cellular chemical homeostasis|
|organelle assembly|
|ion homeostasis|
|cellular component morphogenesis|
|membrane organization|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|response to hormone|
|regulation of cellular localization|
|response to organonitrogen compound|
|regulation of protein localization|
|cellular response to oxygen-containing compound|
|identical protein binding|
|response to nitrogen compound|
|cytoskeleton organization|
|chemical homeostasis|
|response to abiotic stimulus|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|defense response|
|response to endogenous stimulus|
|positive regulation of transcription, DNA-templated|
|response to oxygen-containing compound|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15473
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CSRP3 Expression in NALM6 Cells: -1.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>