======= CTDNEP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTDNEP1
  * **<color #00a2e8>Official Name</color>**: CTD nuclear envelope phosphatase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23399|23399]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95476|O95476]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTDNEP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTDNEP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610684|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. {ECO:0000269|PubMed:17420445, ECO:0000269|PubMed:22134922}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NIF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Nem1-Spo7 phosphatase complex|
|positive regulation of triglyceride biosynthetic process|
|mitotic nuclear envelope disassembly|
|membrane disassembly|
|nuclear envelope disassembly|
|regulation of triglyceride biosynthetic process|
|positive regulation of triglyceride metabolic process|
|regulation of triglyceride metabolic process|
|phosphoprotein phosphatase activity|
|nuclear envelope organization|
|protein serine/threonine phosphatase activity|
|positive regulation of lipid biosynthetic process|
|lipid droplet|
|mesoderm development|
|nucleus organization|
|positive regulation of lipid metabolic process|
|positive regulation of canonical Wnt signaling pathway|
|protein localization to nucleus|
|positive regulation of Wnt signaling pathway|
|nuclear envelope|
|regulation of lipid biosynthetic process|
|protein dephosphorylation|
|nuclear membrane|
|regulation of canonical Wnt signaling pathway|
|dephosphorylation|
|regulation of Wnt signaling pathway|
|regulation of lipid metabolic process|
|cellular component disassembly|
|endomembrane system organization|
|mitotic cell cycle process|
|mitotic cell cycle|
|gamete generation|
|protein localization to organelle|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|membrane organization|
|endoplasmic reticulum membrane|
|multi-organism reproductive process|
|cell cycle process|
|cell cycle|
|reproductive process|
|reproduction|
|cellular protein localization|
|cellular macromolecule localization|
|positive regulation of signal transduction|
|tissue development|
|positive regulation of cell communication|
|positive regulation of signaling|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp169|BH1 1μM R04 exp169]]|-3.58|
|[[:results:exp89|Vemurafenib 6.6μM R02 exp89]]|-2.97|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|-2.62|
|[[:results:exp442|Ibrutinib 10μM R08 exp442]]|-2.38|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|-2.31|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.24|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-2.24|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|-2.2|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.2|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|-2.07|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.02|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.88|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.82|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|-1.81|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.74|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.71|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|1.72|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.76|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|1.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|1.97|
|[[:results:exp135|MS023 7μM R03 exp135]]|2.21|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.24|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cnep1r1|CNEP1R1]]|0.626|
|[[:human genes:g:gfpt1|GFPT1]]|0.572|
|[[:human genes:a:alg5|ALG5]]|0.533|
|[[:human genes:t:thg1l|THG1L]]|0.512|
|[[:human genes:d:dpagt1|DPAGT1]]|0.507|
|[[:human genes:e:eny2|ENY2]]|0.506|
|[[:human genes:m:mbtps2|MBTPS2]]|0.502|
|[[:human genes:c:chka|CHKA]]|0.502|
|[[:human genes:u:ube2g2|UBE2G2]]|0.501|
|[[:human genes:u:ube2k|UBE2K]]|0.499|
|[[:human genes:a:alg6|ALG6]]|0.495|
|[[:human genes:k:kdsr|KDSR]]|0.488|
|[[:human genes:c:cbfb|CBFB]]|0.486|
|[[:human genes:u:uap1|UAP1]]|0.483|
|[[:human genes:p:pmm2|PMM2]]|0.477|
|[[:human genes:p:plaa|PLAA]]|0.474|
|[[:human genes:c:cept1|CEPT1]]|0.473|
|[[:human genes:m:mbtps1|MBTPS1]]|0.472|
|[[:human genes:r:rtcb|RTCB]]|0.467|
|[[:human genes:a:apaf1|APAF1]]|0.465|
|[[:human genes:d:dohh|DOHH]]|0.464|
|[[:human genes:r:rnmt|RNMT]]|0.463|
|[[:human genes:d:dolk|DOLK]]|0.46|
|[[:human genes:r:romo1|ROMO1]]|0.459|
|[[:human genes:l:lsmd1|LSMD1]]|0.458|
|[[:human genes:t:triap1|TRIAP1]]|0.455|
|[[:human genes:d:dad1|DAD1]]|0.453|
|[[:human genes:g:gmppb|GMPPB]]|0.449|
|[[:human genes:t:tmed10|TMED10]]|0.449|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.449|
|[[:human genes:a:alg1|ALG1]]|0.446|
|[[:human genes:a:atp5j|ATP5J]]|0.446|
|[[:human genes:g:gtf3a|GTF3A]]|0.446|
|[[:human genes:a:atp2a2|ATP2A2]]|0.444|
|[[:human genes:r:rce1|RCE1]]|0.444|
|[[:human genes:p:pik3r4|PIK3R4]]|0.437|
|[[:human genes:b:bap1|BAP1]]|0.436|
|[[:human genes:t:tti2|TTI2]]|0.436|
|[[:human genes:d:derl1|DERL1]]|0.433|
|[[:human genes:s:srd5a3|SRD5A3]]|0.431|
|[[:human genes:a:atxn10|ATXN10]]|0.431|
|[[:human genes:f:faf2|FAF2]]|0.431|
|[[:human genes:h:hspd1|HSPD1]]|0.43|
|[[:human genes:s:srp14|SRP14]]|0.429|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.429|
|[[:human genes:r:rptor|RPTOR]]|0.428|
|[[:human genes:c:casp9|CASP9]]|0.426|
|[[:human genes:u:ufm1|UFM1]]|0.425|
|[[:human genes:a:atp5o|ATP5O]]|0.424|
|[[:human genes:a:alg2|ALG2]]|0.424|
|[[:human genes:s:sec63|SEC63]]|0.423|
|[[:human genes:u:uhrf1|UHRF1]]|0.417|
|[[:human genes:s:sec61g|SEC61G]]|0.416|
|[[:human genes:d:dhdds|DHDDS]]|0.416|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.415|
|[[:human genes:u:uba5|UBA5]]|0.414|
|[[:human genes:e:eif4e|EIF4E]]|0.413|
|[[:human genes:c:csnk2b|CSNK2B]]|0.413|
|[[:human genes:f:flvcr1|FLVCR1]]|0.412|
|[[:human genes:p:ppa2|PPA2]]|0.411|
|[[:human genes:m:mtor|MTOR]]|0.41|
|[[:human genes:n:nxt1|NXT1]]|0.409|
|[[:human genes:n:nae1|NAE1]]|0.406|
|[[:human genes:u:uso1|USO1]]|0.405|
|[[:human genes:a:aars|AARS]]|0.403|
|[[:human genes:p:pelo|PELO]]|0.403|
|[[:human genes:e:eif1ax|EIF1AX]]|0.401|
|[[:human genes:c:ccdc101|CCDC101]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 15/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|9/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|1/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|2/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12611
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.45 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTDNEP1 Expression in NALM6 Cells: 6.45'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>