======= CTDP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTDP1
  * **<color #00a2e8>Official Name</color>**: CTD phosphatase subunit 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9150|9150]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5B0|Q9Y5B0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTDP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTDP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604927|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. {ECO:0000269|PubMed:22692537}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NIF|
|FCP1 C|
|PTCB-BRCT|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TFIIF-class transcription factor complex binding|
|dephosphorylation of RNA polymerase II C-terminal domain|
|RNA polymerase II CTD heptapeptide repeat phosphatase activity|
|Tat protein binding|
|negative regulation of cell growth involved in cardiac muscle cell development|
|exit from mitosis|
|negative regulation of cardiac muscle cell differentiation|
|positive regulation by host of viral transcription|
|regulation of cell growth involved in cardiac muscle cell development|
|negative regulation of cardiocyte differentiation|
|negative regulation of heart growth|
|negative regulation of cardiac muscle tissue growth|
|spindle midzone|
|negative regulation of cardiac muscle hypertrophy|
|negative regulation of muscle hypertrophy|
|negative regulation of organ growth|
|negative regulation of cardiac muscle tissue development|
|regulation of cardiac muscle cell differentiation|
|negative regulation of striated muscle cell differentiation|
|positive regulation of viral transcription|
|phosphoprotein phosphatase activity|
|negative regulation of striated muscle tissue development|
|negative regulation of muscle organ development|
|regulation of cardiocyte differentiation|
|negative regulation of muscle tissue development|
|negative regulation of muscle cell differentiation|
|regulation of cardiac muscle hypertrophy|
|regulation of cardiac muscle tissue growth|
|regulation of muscle hypertrophy|
|regulation of heart growth|
|regulation of viral transcription|
|modification by host of symbiont morphology or physiology|
|transcription elongation from RNA polymerase II promoter|
|interaction with symbiont|
|regulation of cardiac muscle tissue development|
|regulation of muscle adaptation|
|DNA-templated transcription, elongation|
|regulation of organ growth|
|regulation of striated muscle cell differentiation|
|negative regulation of developmental growth|
|positive regulation of viral process|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|spindle|
|spindle pole|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|mitotic nuclear division|
|regulation of muscle cell differentiation|
|modification of morphology or physiology of other organism|
|midbody|
|negative regulation of cell growth|
|regulation of viral process|
|protein dephosphorylation|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of muscle system process|
|negative regulation of growth|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear division|
|dephosphorylation|
|organelle fission|
|regulation of developmental growth|
|negative regulation of cell development|
|regulation of cell growth|
|transcription by RNA polymerase II|
|centrosome|
|cell division|
|positive regulation of multi-organism process|
|regulation of system process|
|protein-containing complex|
|mitotic cell cycle process|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|regulation of growth|
|mitotic cell cycle|
|intracellular membrane-bounded organelle|
|negative regulation of cell differentiation|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|regulation of cell development|
|negative regulation of developmental process|
|cell cycle process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|organic cyclic compound biosynthetic process|
|cell cycle|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|regulation of cell differentiation|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.05|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.85|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.74|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.72|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.447|
|[[:human genes:r:rps28|RPS28]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 485/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|23/28|
|blood|21/28|
|bone|14/25|
|breast|26/33|
|central nervous system|34/56|
|cervix|3/4|
|colorectal|14/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|10/15|
|kidney|13/21|
|liver|10/20|
|lung|41/75|
|lymphocyte|10/14|
|ovary|23/26|
|pancreas|18/24|
|peripheral nervous system|13/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|17/24|
|soft tissue|6/7|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|17/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1484
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTDP1 Expression in NALM6 Cells: 5.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>