======= CTLA4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTLA4
  * **<color #00a2e8>Official Name</color>**: cytotoxic T-lymphocyte associated protein 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1493|1493]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P16410|P16410]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTLA4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTLA4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/123890|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein complex involved in cell adhesion|
|negative regulation of regulatory T cell differentiation|
|negative regulation of B cell proliferation|
|clathrin-coated endocytic vesicle|
|negative regulation of B cell activation|
|regulation of regulatory T cell differentiation|
|negative regulation of T cell differentiation|
|negative regulation of lymphocyte differentiation|
|T cell costimulation|
|lymphocyte costimulation|
|negative regulation of T cell proliferation|
|regulation of B cell proliferation|
|negative regulation of lymphocyte proliferation|
|negative regulation of mononuclear cell proliferation|
|negative regulation of leukocyte proliferation|
|negative regulation of leukocyte differentiation|
|negative regulation of T cell activation|
|negative regulation of leukocyte cell-cell adhesion|
|B cell receptor signaling pathway|
|negative regulation of hemopoiesis|
|regulation of T cell differentiation|
|negative regulation of lymphocyte activation|
|negative regulation of immune response|
|regulation of T cell proliferation|
|regulation of lymphocyte differentiation|
|negative regulation of leukocyte activation|
|negative regulation of cell-cell adhesion|
|T cell receptor signaling pathway|
|negative regulation of cell activation|
|positive regulation of T cell activation|
|regulation of B cell activation|
|regulation of lymphocyte proliferation|
|regulation of mononuclear cell proliferation|
|positive regulation of leukocyte cell-cell adhesion|
|regulation of leukocyte proliferation|
|positive regulation of cell-cell adhesion|
|negative regulation of cell adhesion|
|regulation of leukocyte differentiation|
|antigen receptor-mediated signaling pathway|
|regulation of leukocyte cell-cell adhesion|
|regulation of T cell activation|
|positive regulation of lymphocyte activation|
|external side of plasma membrane|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|negative regulation of immune system process|
|immune response-activating cell surface receptor signaling pathway|
|regulation of hemopoiesis|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of lymphocyte activation|
|immune response-activating signal transduction|
|immune response-regulating signaling pathway|
|regulation of leukocyte activation|
|adaptive immune response|
|activation of immune response|
|regulation of cell activation|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|positive regulation of cell death|
|perinuclear region of cytoplasm|
|negative regulation of cell differentiation|
|cellular response to DNA damage stimulus|
|positive regulation of immune response|
|negative regulation of developmental process|
|Golgi apparatus|
|positive regulation of immune system process|
|regulation of immune response|
|negative regulation of multicellular organismal process|
|integral component of plasma membrane|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of immune system process|
|regulation of cell death|
|cellular response to stress|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16391
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTLA4 Expression in NALM6 Cells: -2.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>