======= CTNNA2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTNNA2
  * **<color #00a2e8>Official Name</color>**: catenin alpha 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1496|1496]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P26232|P26232]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTNNA2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTNNA2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/114025|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vinculin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of postsynaptic membrane|
|extrinsic component of presynaptic membrane|
|radial glia guided migration of Purkinje cell|
|modification of postsynaptic actin cytoskeleton|
|negative regulation of Arp2/3 complex-mediated actin nucleation|
|regulation of synapse structural plasticity|
|hindbrain radial glia guided cell migration|
|modification of postsynaptic structure|
|negative regulation of actin nucleation|
|modification of synaptic structure|
|cell migration in hindbrain|
|presynaptic active zone cytoplasmic component|
|prepulse inhibition|
|regulation of Arp2/3 complex-mediated actin nucleation|
|parallel fiber to Purkinje cell synapse|
|postsynaptic density, intracellular component|
|regulation of actin nucleation|
|startle response|
|brain morphogenesis|
|hippocampal mossy fiber to CA3 synapse|
|regulation of neuron migration|
|dendrite morphogenesis|
|adherens junction|
|positive regulation of muscle cell differentiation|
|dendrite development|
|structural constituent of cytoskeleton|
|cell-cell adherens junction|
|neuromuscular process|
|negative regulation of supramolecular fiber organization|
|negative regulation of cytoskeleton organization|
|hindbrain development|
|regulation of muscle cell differentiation|
|regulation of actin filament polymerization|
|lamellipodium|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|basolateral plasma membrane|
|actin filament binding|
|actin cytoskeleton|
|regulation of synapse organization|
|regulation of protein polymerization|
|regulation of synapse structure or activity|
|regulation of actin filament organization|
|synapse organization|
|axon|
|cadherin binding|
|regulation of actin cytoskeleton organization|
|regulation of supramolecular fiber organization|
|negative regulation of response to external stimulus|
|axonogenesis|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of actin filament-based process|
|axon development|
|cell morphogenesis involved in neuron differentiation|
|regulation of protein complex assembly|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of neuron projection development|
|cell-cell adhesion|
|regulation of anatomical structure size|
|cell part morphogenesis|
|regulation of cytoskeleton organization|
|cell morphogenesis involved in differentiation|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of plasma membrane bounded cell projection organization|
|negative regulation of cellular component organization|
|regulation of cell projection organization|
|cell morphogenesis|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of cell migration|
|regulation of cell motility|
|regulation of nervous system development|
|cell adhesion|
|regulation of cell development|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|cell migration|
|positive regulation of cell differentiation|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|neuron differentiation|
|identical protein binding|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of organelle organization|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|generation of neurons|
|movement of cell or subcellular component|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|regulation of cell differentiation|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.467|
|[[:human genes:p:polr2j3|POLR2J3]]|0.417|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5346
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTNNA2 Expression in NALM6 Cells: 0.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>