======= CTNNBL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CTNNBL1
  * **<color #00a2e8>Official Name</color>**: catenin beta like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56259|56259]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WYA6|Q8WYA6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CTNNBL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CTNNBL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611537|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF1716|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Prp19 complex|
|somatic diversification of immunoglobulins|
|somatic diversification of immune receptors|
|spliceosomal complex|
|immunoglobulin production|
|production of molecular mediator of immune response|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions|
|enzyme binding|
|RNA splicing|
|mRNA processing|
|positive regulation of apoptotic process|
|immune system development|
|positive regulation of programmed cell death|
|mRNA metabolic process|
|positive regulation of cell death|
|RNA processing|
|apoptotic process|
|programmed cell death|
|cell death|
|regulation of apoptotic process|
|regulation of programmed cell death|
|RNA metabolic process|
|regulation of cell death|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-2.59|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.26|
|[[:results:exp532|TIC10 10μM R08 exp532]]|-2.05|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.03|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-1.85|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-1.71|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-1.7|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|1.71|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.71|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.72|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.77|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|1.99|
|[[:results:exp120|Dimethyl-Sulfoxide 1pc R03 exp120]]|2.05|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.29|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.47|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|2.49|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.85|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|3.98|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:cdk8|CDK8]]|0.496|
|[[:human genes:c:ckap5|CKAP5]]|0.444|
|[[:human genes:p:pds5b|PDS5B]]|0.425|
|[[:human genes:a:arid4b|ARID4B]]|0.421|
|[[:human genes:c:cwc22|CWC22]]|0.417|
|[[:human genes:p:ptma|PTMA]]|0.414|
|[[:human genes:t:tsc2|TSC2]]|0.414|
|[[:human genes:c:c9orf78|C9orf78]]|0.412|
|[[:human genes:p:pcgf1|PCGF1]]|0.408|
|[[:human genes:e:e2f2|E2F2]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 328/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|15/28|
|blood|17/28|
|bone|17/26|
|breast|15/33|
|central nervous system|32/56|
|cervix|0/4|
|colorectal|7/17|
|esophagus|5/13|
|fibroblast|1/1|
|gastric|4/16|
|kidney|9/21|
|liver|9/20|
|lung|42/75|
|lymphocyte|6/16|
|ovary|9/26|
|pancreas|11/24|
|peripheral nervous system|13/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|3/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1443
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CTNNBL1 Expression in NALM6 Cells: 5.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>