======= CUBN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CUBN
  * **<color #00a2e8>Official Name</color>**: cubilin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8029|8029]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60494|O60494]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CUBN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CUBN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602997|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269|PubMed:10371504, ECO:0000269|PubMed:11606717, ECO:0000269|PubMed:11717447, ECO:0000269|PubMed:14576052, ECO:0000269|PubMed:9572993}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|EGF CA|
|EGF|
|EGF 3|
|CUB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|extrinsic component of external side of plasma membrane|
|cobalamin transport|
|cobalamin binding|
|high-density lipoprotein particle clearance|
|lipoprotein localization|
|lipoprotein transport|
|cargo receptor activity|
|vitamin D metabolic process|
|cobalamin metabolic process|
|fat-soluble vitamin metabolic process|
|vitamin transport|
|plasma lipoprotein particle clearance|
|cofactor transport|
|brush border membrane|
|clathrin-coated pit|
|drug binding|
|endocytic vesicle|
|tetrapyrrole metabolic process|
|regulation of plasma lipoprotein particle levels|
|water-soluble vitamin metabolic process|
|lysosomal lumen|
|cholesterol metabolic process|
|vitamin metabolic process|
|secondary alcohol metabolic process|
|sterol metabolic process|
|drug transport|
|tissue homeostasis|
|signaling receptor activity|
|endosome membrane|
|receptor-mediated endocytosis|
|steroid metabolic process|
|lysosomal membrane|
|alcohol metabolic process|
|apical plasma membrane|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|cofactor metabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|endocytosis|
|import into cell|
|response to bacterium|
|calcium ion binding|
|protein homodimerization activity|
|Golgi apparatus|
|endoplasmic reticulum|
|response to drug|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|homeostatic process|
|small molecule metabolic process|
|nitrogen compound transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-1.98|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.75|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11927
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.4 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CUBN Expression in NALM6 Cells: 2.4'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>