======= CXCL6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCL6
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine ligand 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6372|6372]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P80162|P80162]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCL6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCL6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/138965|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram- negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7). {ECO:0000269|PubMed:18443119, ECO:0000269|PubMed:8399143, ECO:0000269|PubMed:8423327, ECO:0000269|PubMed:9057843}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|IL8|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of neutrophil mediated killing of gram-negative bacterium|
|regulation of neutrophil mediated killing of bacterium|
|regulation of neutrophil mediated killing of symbiont cell|
|regulation of neutrophil mediated cytotoxicity|
|regulation of killing of cells of other organism|
|regulation of defense response to bacterium|
|chemokine activity|
|regulation of myeloid leukocyte mediated immunity|
|antimicrobial humoral immune response mediated by antimicrobial peptide|
|leukocyte homeostasis|
|regulation of leukocyte mediated cytotoxicity|
|regulation of chemokine production|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|granulocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|granulocyte migration|
|regulation of cell killing|
|antimicrobial humoral response|
|myeloid leukocyte migration|
|leukocyte chemotaxis|
|heparin binding|
|cellular response to lipopolysaccharide|
|cellular response to molecule of bacterial origin|
|homeostasis of number of cells|
|regulation of leukocyte mediated immunity|
|cell chemotaxis|
|cellular response to biotic stimulus|
|regulation of symbiosis, encompassing mutualism through parasitism|
|response to lipopolysaccharide|
|response to molecule of bacterial origin|
|defense response to bacterium|
|humoral immune response|
|leukocyte migration|
|regulation of immune effector process|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|cellular response to lipid|
|regulation of response to biotic stimulus|
|chemotaxis|
|taxis|
|myeloid leukocyte activation|
|cytokine-mediated signaling pathway|
|response to bacterium|
|regulation of cytokine production|
|regulation of defense response|
|regulation of multi-organism process|
|response to lipid|
|leukocyte activation|
|defense response to other organism|
|cell migration|
|cellular response to cytokine stimulus|
|cellular response to oxygen-containing compound|
|cell activation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|response to cytokine|
|cell-cell signaling|
|response to other organism|
|response to external biotic stimulus|
|locomotion|
|G protein-coupled receptor signaling pathway|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|extracellular space|
|homeostatic process|
|regulation of immune system process|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|-1.95|
|[[:results:exp40|2-Methoxyestradiol 0.2μM R01 exp40]]|-1.9|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|-1.81|
|[[:results:exp153|SGC2096 2.6μM R03 exp153]]|2.08|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14128
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCL6 Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>