======= CXCR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCR2
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3579|3579]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P25025|P25025]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/146928|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-8-mediated signaling pathway|
|negative regulation of neutrophil apoptotic process|
|interleukin-8 receptor activity|
|cellular response to interleukin-8|
|response to interleukin-8|
|interleukin-8 binding|
|C-X-C chemokine receptor activity|
|regulation of neutrophil apoptotic process|
|acute inflammatory response to antigenic stimulus|
|positive regulation of vascular permeability|
|metanephric tubule morphogenesis|
|positive regulation of striated muscle cell apoptotic process|
|positive regulation of cardiac muscle cell apoptotic process|
|negative regulation of myeloid cell apoptotic process|
|metanephric tubule development|
|dendritic cell chemotaxis|
|metanephric epithelium development|
|dendritic cell migration|
|mast cell granule|
|C-C chemokine receptor activity|
|C-C chemokine binding|
|inflammatory response to antigenic stimulus|
|chemokine binding|
|positive regulation of neutrophil chemotaxis|
|positive regulation of granulocyte chemotaxis|
|positive regulation of muscle cell apoptotic process|
|regulation of neutrophil chemotaxis|
|regulation of myeloid cell apoptotic process|
|positive regulation of neutrophil migration|
|regulation of neutrophil migration|
|regulation of vascular permeability|
|regulation of cardiac muscle cell apoptotic process|
|regulation of striated muscle cell apoptotic process|
|regulation of granulocyte chemotaxis|
|negative regulation of leukocyte apoptotic process|
|cellular defense response|
|receptor internalization|
|regulation of muscle cell apoptotic process|
|acute inflammatory response|
|chemokine-mediated signaling pathway|
|neutrophil chemotaxis|
|regulation of leukocyte apoptotic process|
|metanephros development|
|midbrain development|
|positive regulation of leukocyte chemotaxis|
|granulocyte chemotaxis|
|cellular response to chemokine|
|response to chemokine|
|neutrophil migration|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|secretory granule membrane|
|granulocyte migration|
|receptor metabolic process|
|regulation of leukocyte chemotaxis|
|myeloid leukocyte migration|
|positive regulation of leukocyte migration|
|kidney epithelium development|
|positive regulation of chemotaxis|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|positive regulation of angiogenesis|
|vascular process in circulatory system|
|positive regulation of vasculature development|
|regulation of leukocyte migration|
|cell chemotaxis|
|regulation of chemotaxis|
|receptor-mediated endocytosis|
|kidney development|
|positive regulation of cytosolic calcium ion concentration|
|renal system development|
|regulation of angiogenesis|
|epithelial tube morphogenesis|
|urogenital system development|
|regulation of vasculature development|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|leukocyte migration|
|blood circulation|
|external side of plasma membrane|
|circulatory system process|
|morphogenesis of an epithelium|
|cellular calcium ion homeostasis|
|negative regulation of immune system process|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|inflammatory response|
|neutrophil mediated immunity|
|positive regulation of cell migration|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|positive regulation of cell motility|
|myeloid cell activation involved in immune response|
|positive regulation of cellular component movement|
|chemotaxis|
|positive regulation of locomotion|
|taxis|
|endocytosis|
|cellular metal ion homeostasis|
|tissue morphogenesis|
|myeloid leukocyte activation|
|positive regulation of response to external stimulus|
|cell surface|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|cellular cation homeostasis|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|import into cell|
|positive regulation of cell death|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|brain development|
|cellular chemical homeostasis|
|leukocyte mediated immunity|
|head development|
|ion homeostasis|
|exocytosis|
|tube development|
|regulation of cell migration|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|leukocyte activation|
|cell migration|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|secretion by cell|
|cellular response to cytokine stimulus|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|epithelium development|
|secretion|
|positive regulation of immune system process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|positive regulation of developmental process|
|integral component of plasma membrane|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|homeostatic process|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|tissue development|
|immune response|
|vesicle-mediated transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3962
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCR2 Expression in NALM6 Cells: 0.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>