======= CXCR3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXCR3
  * **<color #00a2e8>Official Name</color>**: C-X-C motif chemokine receptor 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2833|2833]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49682|P49682]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXCR3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXCR3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300574|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. {ECO:0000269|PubMed:12782716}. Isoform 3: Mediates the activity of CXCL11.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|C-X-C chemokine receptor activity|
|T cell chemotaxis|
|chemokine receptor activity|
|C-C chemokine receptor activity|
|C-C chemokine binding|
|chemokine binding|
|T cell migration|
|lymphocyte chemotaxis|
|lymphocyte migration|
|chemokine-mediated signaling pathway|
|response to chemokine|
|cellular response to chemokine|
|leukocyte chemotaxis|
|calcium-mediated signaling|
|regulation of leukocyte migration|
|cell chemotaxis|
|positive regulation of cytosolic calcium ion concentration|
|angiogenesis|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|leukocyte migration|
|external side of plasma membrane|
|blood vessel morphogenesis|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|blood vessel development|
|divalent inorganic cation homeostasis|
|inflammatory response|
|vasculature development|
|cardiovascular system development|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|tube morphogenesis|
|cytokine-mediated signaling pathway|
|regulation of cell adhesion|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|cellular homeostasis|
|regulation of cell motility|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|cell migration|
|regulation of locomotion|
|regulation of cellular component movement|
|cellular response to cytokine stimulus|
|programmed cell death|
|localization of cell|
|cell motility|
|cell death|
|response to cytokine|
|chemical homeostasis|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|integral component of plasma membrane|
|movement of cell or subcellular component|
|homeostatic process|
|regulation of immune system process|
|intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.536|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13515
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -4.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXCR3 Expression in NALM6 Cells: -4.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>