======= CXorf56 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CXorf56
  * **<color #00a2e8>Official Name</color>**: chromosome X open reading frame 56
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=63932|63932]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H5V9|Q9H5V9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CXorf56&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CXorf56|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  While this gene is well-supported by transcript data, no functional information on its protein products is currently available. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell body|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-2.73|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|-2.68|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-2.48|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-2.47|
|[[:results:exp430|Rifampicin 30μM R08 exp430]]|-2.38|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-2.27|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.23|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-2.21|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-2.12|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|-2.09|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.07|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-2|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.98|
|[[:results:exp247|UM0130462 0.025 to 0.035μM day4 R05 exp247]]|-1.92|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.89|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.89|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.88|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.88|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.86|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|-1.83|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.74|
|[[:results:exp130|JQ1 0.01μM R03 exp130]]|-1.74|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.72|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-1.71|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|1.7|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|1.71|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|1.71|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|1.72|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.74|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|1.76|
|[[:results:exp518|RK-33 8μM R08 exp518]]|1.77|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.79|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|1.8|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.8|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|1.8|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|1.8|
|[[:results:exp116|AICAR 240μM R03 exp116]]|1.85|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.86|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|1.9|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.91|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.91|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.92|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.92|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.93|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.94|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.98|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|2.05|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.09|
|[[:results:exp465|Cannabidiol 13μM R08 exp465]]|2.11|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.12|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.15|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|2.21|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.21|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|2.25|
|[[:results:exp504|MK2206 4μM R08 exp504]]|2.35|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|2.49|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.58|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|2.59|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.59|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.59|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.62|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.64|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|2.67|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|2.68|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|2.69|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|2.78|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.92|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|3.14|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|3.21|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|3.48|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|3.68|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|3.72|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|4.32|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|4.39|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:ptar1|PTAR1]]|0.489|
|[[:human genes:g:gemin7|GEMIN7]]|0.482|
|[[:human genes:c:c11orf57|C11orf57]]|0.47|
|[[:human genes:k:kdm8|KDM8]]|0.47|
|[[:human genes:c:cbll1|CBLL1]]|0.465|
|[[:human genes:m:mettl14|METTL14]]|0.457|
|[[:human genes:f:fh|FH]]|0.454|
|[[:human genes:p:pdcd6ip|PDCD6IP]]|0.45|
|[[:human genes:r:rabggtb|RABGGTB]]|0.45|
|[[:human genes:p:ppp6c|PPP6C]]|0.448|
|[[:human genes:p:pgm3|PGM3]]|0.446|
|[[:human genes:d:dph1|DPH1]]|0.438|
|[[:human genes:d:dhrsx|DHRSX]]|0.436|
|[[:human genes:c:c16orf80|C16orf80]]|0.435|
|[[:human genes:w:wdr83|WDR83]]|0.434|
|[[:human genes:r:rpp21|RPP21]]|0.43|
|[[:human genes:r:rbm26|RBM26]]|0.429|
|[[:human genes:u:urm1|URM1]]|0.428|
|[[:human genes:p:ppcs|PPCS]]|0.423|
|[[:human genes:p:ppcdc|PPCDC]]|0.422|
|[[:human genes:p:prkrip1|PRKRIP1]]|0.418|
|[[:human genes:d:dph5|DPH5]]|0.417|
|[[:human genes:g:gemin6|GEMIN6]]|0.417|
|[[:human genes:z:zcrb1|ZCRB1]]|0.416|
|[[:human genes:p:pmvk|PMVK]]|0.414|
|[[:human genes:c:c15orf41|C15orf41]]|0.413|
|[[:human genes:r:rpia|RPIA]]|0.407|
|[[:human genes:z:znhit1|ZNHIT1]]|0.405|
|[[:human genes:f:fkbpl|FKBPL]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 11/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|1/19|
|lung|1/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6384
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CXorf56 Expression in NALM6 Cells: 8.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>