======= CYB561A3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYB561A3
  * **<color #00a2e8>Official Name</color>**: cytochrome b561 family member A3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=220002|220002]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NBI2|Q8NBI2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYB561A3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYB561A3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/618757|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ferric-chelate reductase that reduces Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm. Probably uses ascorbate as electron donor (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cytochrom B561|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|late endosome membrane|
|oxidoreductase activity|
|lysosomal membrane|
|oxidation-reduction process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.79|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.59|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.4|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.36|
|[[:results:exp518|RK-33 8μM R08 exp518]]|-2.22|
|[[:results:exp454|Bafilomycin-A1 0.009μM R08 exp454]]|-2.12|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|-1.95|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|-1.83|
|[[:results:exp145|PNU96415E 10μM R03 exp145]]|1.71|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.72|
|[[:results:exp12|Chloramphenicol 2μM R00 exp12]]|1.72|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.77|
|[[:results:exp11|CCCP 1μM R00 exp11]]|1.78|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|1.81|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|1.83|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|1.89|
|[[:results:exp225|Celastrol 0.12μM R05 exp225]]|1.93|
|[[:results:exp232|Epothilone-D 0.004 to 0.006μM on day4 R05 exp232]]|2.01|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|2.02|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|2.41|
|[[:results:exp317|Geldanamycin 0.015 to 0.05μM on day4 R07 exp317]]|3.09|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:ankh|ANKH]]|0.536|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.527|
|[[:human genes:t:tgfbrap1|TGFBRAP1]]|0.489|
|[[:human genes:t:tfrc|TFRC]]|0.487|
|[[:human genes:n:nufip2|NUFIP2]]|0.432|
|[[:human genes:s:slc11a2|SLC11A2]]|0.422|
|[[:human genes:w:wdr75|WDR75]]|0.412|
|[[:human genes:r:rps12|RPS12]]|0.412|
|[[:human genes:p:psmb4|PSMB4]]|0.411|
|[[:human genes:a:agfg1|AGFG1]]|0.408|
|[[:human genes:i:iscu|ISCU]]|0.408|
|[[:human genes:p:prim1|PRIM1]]|0.408|
|[[:human genes:p:pole4|POLE4]]|0.404|
|[[:human genes:a:arid4b|ARID4B]]|0.402|
|[[:human genes:v:vps8|VPS8]]|0.402|
|[[:human genes:c:cdc73|CDC73]]|0.402|
|[[:human genes:s:sf3a3|SF3A3]]|0.401|
|[[:human genes:r:rbm39|RBM39]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1700
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYB561A3 Expression in NALM6 Cells: 6.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>