======= CYP11B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP11B1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 11 subfamily B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1584|1584]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P15538|P15538]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP11B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP11B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610613|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|corticosterone 18-monooxygenase activity|
|steroid 11-beta-monooxygenase activity|
|aldosterone biosynthetic process|
|tertiary alcohol biosynthetic process|
|cortisol biosynthetic process|
|aldosterone metabolic process|
|cortisol metabolic process|
|primary alcohol biosynthetic process|
|mineralocorticoid biosynthetic process|
|mineralocorticoid metabolic process|
|aldehyde biosynthetic process|
|cellular response to potassium ion|
|glucocorticoid biosynthetic process|
|tertiary alcohol metabolic process|
|response to potassium ion|
|C21-steroid hormone biosynthetic process|
|glucocorticoid metabolic process|
|C21-steroid hormone metabolic process|
|ketone biosynthetic process|
|steroid hormone biosynthetic process|
|cellular aldehyde metabolic process|
|hormone biosynthetic process|
|cellular ketone metabolic process|
|primary alcohol metabolic process|
|alcohol biosynthetic process|
|cholesterol metabolic process|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|iron ion binding|
|sterol metabolic process|
|heme binding|
|regulation of blood pressure|
|glucose homeostasis|
|carbohydrate homeostasis|
|organic hydroxy compound biosynthetic process|
|cellular response to metal ion|
|hormone metabolic process|
|cellular response to inorganic substance|
|steroid metabolic process|
|cellular response to peptide hormone stimulus|
|alcohol metabolic process|
|cellular response to peptide|
|response to metal ion|
|blood circulation|
|response to peptide hormone|
|mitochondrial inner membrane|
|circulatory system process|
|organic hydroxy compound metabolic process|
|response to peptide|
|drug metabolic process|
|response to inorganic substance|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|cellular response to nitrogen compound|
|response to hormone|
|oxidation-reduction process|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|response to nitrogen compound|
|chemical homeostasis|
|lipid metabolic process|
|cellular response to endogenous stimulus|
|mitochondrion|
|organic cyclic compound biosynthetic process|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|homeostatic process|
|small molecule metabolic process|
|immune response|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17305
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP11B1 Expression in NALM6 Cells: -0.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>