======= CYP19A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP19A1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 19 subfamily A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1588|1588]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11511|P11511]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP19A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP19A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/107910|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of estradiol secretion|
|regulation of estradiol secretion|
|negative regulation of chronic inflammatory response|
|androgen catabolic process|
|testosterone biosynthetic process|
|negative regulation of macrophage chemotaxis|
|regulation of chronic inflammatory response|
|negative regulation of macrophage migration|
|prostate gland growth|
|estrogen biosynthetic process|
|aromatase activity|
|hormone catabolic process|
|female genitalia development|
|negative regulation of leukocyte chemotaxis|
|uterus development|
|regulation of macrophage chemotaxis|
|steroid catabolic process|
|androgen metabolic process|
|ketone biosynthetic process|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|
|estrogen metabolic process|
|oxygen binding|
|steroid hydroxylase activity|
|regulation of macrophage migration|
|prostate gland development|
|negative regulation of leukocyte migration|
|steroid hormone biosynthetic process|
|genitalia development|
|negative regulation of chemotaxis|
|positive regulation of lipid transport|
|hormone biosynthetic process|
|cellular ketone metabolic process|
|electron transfer activity|
|positive regulation of lipid localization|
|female gonad development|
|development of primary female sexual characteristics|
|organ growth|
|female sex differentiation|
|regulation of lipid transport|
|regulation of leukocyte chemotaxis|
|cellular hormone metabolic process|
|steroid biosynthetic process|
|mammary gland development|
|positive regulation of hormone secretion|
|iron ion binding|
|sterol metabolic process|
|negative regulation of inflammatory response|
|regulation of lipid localization|
|heme binding|
|electron transport chain|
|organic hydroxy compound biosynthetic process|
|regulation of leukocyte migration|
|hormone metabolic process|
|negative regulation of defense response|
|gonad development|
|regulation of chemotaxis|
|development of primary sexual characteristics|
|negative regulation of cell migration|
|steroid metabolic process|
|sex differentiation|
|regulation of hormone secretion|
|negative regulation of cell motility|
|lipid catabolic process|
|negative regulation of cellular component movement|
|urogenital system development|
|negative regulation of locomotion|
|regulation of inflammatory response|
|negative regulation of response to external stimulus|
|developmental growth|
|growth|
|positive regulation of secretion by cell|
|gland development|
|generation of precursor metabolites and energy|
|reproductive structure development|
|reproductive system development|
|positive regulation of secretion|
|negative regulation of immune system process|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|developmental process involved in reproduction|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of secretion|
|regulation of cell migration|
|regulation of cell motility|
|endoplasmic reticulum membrane|
|oxidation-reduction process|
|regulation of locomotion|
|positive regulation of transport|
|regulation of cellular component movement|
|endoplasmic reticulum|
|regulation of response to external stimulus|
|lipid metabolic process|
|organic cyclic compound biosynthetic process|
|reproductive process|
|reproduction|
|regulation of response to stress|
|negative regulation of response to stimulus|
|regulation of immune system process|
|small molecule metabolic process|
|organic substance catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4951
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP19A1 Expression in NALM6 Cells: -1.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>