======= CYP1A1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP1A1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 1 subfamily A member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1543|1543]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P04798|P04798]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP1A1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP1A1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/108330|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|flavonoid 3-monooxygenase activity|
|oxidoreductase activity, acting on diphenols and related substances as donors|
|ethylene metabolic process|
|dibenzo-p-dioxin catabolic process|
|arachidonic acid monooxygenase activity|
|vitamin D 24-hydroxylase activity|
|insecticide metabolic process|
|cellular alkene metabolic process|
|olefin metabolic process|
|response to nematode|
|dibenzo-p-dioxin metabolic process|
|9-cis-retinoic acid biosynthetic process|
|9-cis-retinoic acid metabolic process|
|estrogen 2-hydroxylase activity|
|response to iron(III) ion|
|demethylase activity|
|maternal process involved in parturition|
|lipid hydroxylation|
|coumarin metabolic process|
|retinoic acid biosynthetic process|
|hydrogen peroxide biosynthetic process|
|phenylpropanoid metabolic process|
|diterpenoid biosynthetic process|
|estrogen 16-alpha-hydroxylase activity|
|omega-hydroxylase P450 pathway|
|antibiotic biosynthetic process|
|response to herbicide|
|hepatocyte differentiation|
|xenobiotic catabolic process|
|lyase activity|
|vitamin D metabolic process|
|terpenoid biosynthetic process|
|flavonoid metabolic process|
|parturition|
|response to insecticide|
|response to vitamin A|
|epoxygenase P450 pathway|
|response to hyperoxia|
|response to food|
|toxin metabolic process|
|reactive oxygen species biosynthetic process|
|response to immobilization stress|
|isoprenoid biosynthetic process|
|response to increased oxygen levels|
|long-chain fatty acid biosynthetic process|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|
|cellular response to copper ion|
|retinoic acid metabolic process|
|response to arsenic-containing substance|
|estrogen metabolic process|
|monooxygenase activity|
|oxygen binding|
|response to iron ion|
|positive regulation of G1/S transition of mitotic cell cycle|
|fat-soluble vitamin metabolic process|
|hydrogen peroxide metabolic process|
|porphyrin-containing compound metabolic process|
|retinol metabolic process|
|Hsp90 protein binding|
|Hsp70 protein binding|
|response to copper ion|
|positive regulation of cell cycle G1/S phase transition|
|secondary metabolic process|
|arachidonic acid metabolic process|
|tetrapyrrole metabolic process|
|demethylation|
|amine metabolic process|
|primary alcohol metabolic process|
|positive regulation of mitotic cell cycle phase transition|
|response to vitamin|
|positive regulation of cell cycle phase transition|
|retinoid metabolic process|
|antibiotic metabolic process|
|unsaturated fatty acid metabolic process|
|diterpenoid metabolic process|
|icosanoid metabolic process|
|reactive oxygen species metabolic process|
|long-chain fatty acid metabolic process|
|oxidoreductase activity|
|fatty acid biosynthetic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|vitamin metabolic process|
|liver development|
|hepaticobiliary system development|
|digestive tract development|
|xenobiotic metabolic process|
|iron ion binding|
|isoprenoid metabolic process|
|heme binding|
|digestive system development|
|regulation of G1/S transition of mitotic cell cycle|
|positive regulation of mitotic cell cycle|
|regulation of cell cycle G1/S phase transition|
|fatty acid derivative metabolic process|
|monocarboxylic acid biosynthetic process|
|cellular response to xenobiotic stimulus|
|cellular response to metal ion|
|lipid modification|
|hormone metabolic process|
|multi-multicellular organism process|
|cofactor biosynthetic process|
|response to nutrient|
|cellular response to inorganic substance|
|steroid metabolic process|
|aging|
|response to virus|
|positive regulation of cell cycle process|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|response to antibiotic|
|organic acid biosynthetic process|
|camera-type eye development|
|response to lipopolysaccharide|
|alcohol metabolic process|
|fatty acid metabolic process|
|response to molecule of bacterial origin|
|response to hypoxia|
|enzyme binding|
|response to decreased oxygen levels|
|eye development|
|visual system development|
|sensory system development|
|response to metal ion|
|positive regulation of cell cycle|
|response to oxygen levels|
|regulation of lipid metabolic process|
|mitochondrial inner membrane|
|gland development|
|regulation of mitotic cell cycle phase transition|
|heterocycle catabolic process|
|small molecule catabolic process|
|cofactor metabolic process|
|aromatic compound catabolic process|
|regulation of cell cycle phase transition|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|response to nutrient levels|
|drug metabolic process|
|response to toxic substance|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|sensory organ development|
|cell population proliferation|
|response to wounding|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|regulation of mitotic cell cycle|
|epithelial cell differentiation|
|intracellular membrane-bounded organelle|
|response to bacterium|
|regulation of cell cycle process|
|multicellular organismal reproductive process|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|carboxylic acid metabolic process|
|response to organic cyclic compound|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|multi-organism reproductive process|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|epithelium development|
|response to abiotic stimulus|
|regulation of cell cycle|
|lipid metabolic process|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-2.43|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.37|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-2.1|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12990
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.85 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP1A1 Expression in NALM6 Cells: -1.85'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>