======= CYP1B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP1B1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 1 subfamily B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1545|1545]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16678|Q16678]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP1B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP1B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601771|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression. {ECO:0000269|PubMed:10426814, ECO:0000269|PubMed:15258110, ECO:0000269|PubMed:22888116, ECO:0000269|PubMed:23821647}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|trabecular meshwork development|
|endothelial cell-cell adhesion|
|retinal blood vessel morphogenesis|
|estrogen 16-alpha-hydroxylase activity|
|omega-hydroxylase P450 pathway|
|retina vasculature morphogenesis in camera-type eye|
|negative regulation of cell adhesion mediated by integrin|
|nitric oxide biosynthetic process|
|retinal metabolic process|
|epithelial cell-cell adhesion|
|intrinsic apoptotic signaling pathway in response to oxidative stress|
|retina vasculature development in camera-type eye|
|nitric oxide metabolic process|
|epoxygenase P450 pathway|
|cell death in response to oxidative stress|
|reactive nitrogen species metabolic process|
|toxin metabolic process|
|reactive oxygen species biosynthetic process|
|positive regulation of vascular endothelial growth factor production|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|
|regulation of vascular endothelial growth factor production|
|oxygen binding|
|estrogen metabolic process|
|monooxygenase activity|
|membrane lipid catabolic process|
|retinol metabolic process|
|neurotransmitter biosynthetic process|
|regulation of cell adhesion mediated by integrin|
|collagen fibril organization|
|cellular aldehyde metabolic process|
|secondary metabolic process|
|arachidonic acid metabolic process|
|endothelial cell migration|
|cellular response to hydrogen peroxide|
|primary alcohol metabolic process|
|negative regulation of NF-kappaB transcription factor activity|
|epithelial cell migration|
|positive regulation of receptor signaling pathway via JAK-STAT|
|epithelium migration|
|positive regulation of receptor signaling pathway via STAT|
|neurotransmitter metabolic process|
|tissue migration|
|retinoid metabolic process|
|unsaturated fatty acid metabolic process|
|diterpenoid metabolic process|
|icosanoid metabolic process|
|reactive oxygen species metabolic process|
|long-chain fatty acid metabolic process|
|cellular response to antibiotic|
|response to hydrogen peroxide|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|regulation of receptor signaling pathway via JAK-STAT|
|cellular response to reactive oxygen species|
|xenobiotic metabolic process|
|iron ion binding|
|regulation of receptor signaling pathway via STAT|
|sterol metabolic process|
|isoprenoid metabolic process|
|retina development in camera-type eye|
|heme binding|
|intrinsic apoptotic signaling pathway|
|negative regulation of DNA-binding transcription factor activity|
|positive regulation of angiogenesis|
|fatty acid derivative metabolic process|
|ameboidal-type cell migration|
|regulation of reactive oxygen species metabolic process|
|positive regulation of vasculature development|
|cellular response to xenobiotic stimulus|
|response to reactive oxygen species|
|cellular lipid catabolic process|
|hormone metabolic process|
|membrane lipid metabolic process|
|cellular response to toxic substance|
|visual perception|
|sensory perception of light stimulus|
|cellular response to oxidative stress|
|negative regulation of cell migration|
|steroid metabolic process|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|apoptotic signaling pathway|
|regulation of angiogenesis|
|lipid catabolic process|
|response to xenobiotic stimulus|
|response to antibiotic|
|negative regulation of cellular component movement|
|camera-type eye development|
|alcohol metabolic process|
|angiogenesis|
|regulation of vasculature development|
|negative regulation of locomotion|
|fatty acid metabolic process|
|extracellular matrix organization|
|regulation of neurotransmitter levels|
|eye development|
|visual system development|
|sensory system development|
|response to oxidative stress|
|extracellular structure organization|
|cellular response to drug|
|blood vessel morphogenesis|
|regulation of DNA-binding transcription factor activity|
|positive regulation of cytokine production|
|organic hydroxy compound metabolic process|
|supramolecular fiber organization|
|blood vessel development|
|drug metabolic process|
|cell-cell adhesion|
|response to toxic substance|
|vasculature development|
|cardiovascular system development|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|response to inorganic substance|
|cellular response to organic cyclic compound|
|sensory organ development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|regulation of cytokine production|
|positive regulation of cell death|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|carboxylic acid metabolic process|
|regulation of cell motility|
|response to organic cyclic compound|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|cell migration|
|oxidation-reduction process|
|sensory perception|
|regulation of locomotion|
|regulation of cellular component movement|
|oxoacid metabolic process|
|response to drug|
|organic acid metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|localization of cell|
|cell motility|
|cell death|
|negative regulation of molecular function|
|lipid metabolic process|
|mitochondrion|
|locomotion|
|positive regulation of developmental process|
|nervous system process|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|protein-containing complex subunit organization|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12185
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.7 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP1B1 Expression in NALM6 Cells: -3.7'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>