======= CYP26B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP26B1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 26 subfamily B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56603|56603]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NR63|Q9NR63]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP26B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP26B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605207|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of tongue muscle cell differentiation|
|positive regulation of tongue muscle cell differentiation|
|positive regulation of skeletal muscle fiber differentiation|
|diterpenoid catabolic process|
|retinoic acid catabolic process|
|regulation of skeletal muscle fiber differentiation|
|terpenoid catabolic process|
|positive regulation of skeletal muscle cell differentiation|
|establishment of T cell polarity|
|establishment of lymphocyte polarity|
|tongue morphogenesis|
|isoprenoid catabolic process|
|retinoic acid 4-hydroxylase activity|
|negative regulation of retinoic acid receptor signaling pathway|
|fat-soluble vitamin catabolic process|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen|
|vitamin catabolic process|
|regulation of retinoic acid receptor signaling pathway|
|retinoic acid receptor signaling pathway|
|response to vitamin A|
|regulation of skeletal muscle cell differentiation|
|tongue development|
|establishment of skin barrier|
|positive regulation of skeletal muscle tissue development|
|retinoic acid binding|
|regulation of water loss via skin|
|retinoic acid metabolic process|
|proximal/distal pattern formation|
|positive regulation of myotube differentiation|
|fat-soluble vitamin metabolic process|
|cell fate determination|
|male meiotic nuclear division|
|regulation of skeletal muscle tissue development|
|regulation of myotube differentiation|
|positive regulation of striated muscle cell differentiation|
|multicellular organismal water homeostasis|
|positive regulation of striated muscle tissue development|
|positive regulation of muscle organ development|
|cellular response to retinoic acid|
|positive regulation of muscle tissue development|
|water homeostasis|
|positive regulation of muscle cell differentiation|
|response to vitamin|
|regulation of striated muscle cell differentiation|
|retinoid metabolic process|
|response to retinoic acid|
|diterpenoid metabolic process|
|cornification|
|bone morphogenesis|
|establishment of cell polarity|
|monocarboxylic acid catabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|vitamin metabolic process|
|embryonic appendage morphogenesis|
|embryonic limb morphogenesis|
|xenobiotic metabolic process|
|regulation of striated muscle tissue development|
|iron ion binding|
|sterol metabolic process|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|isoprenoid metabolic process|
|regulation of T cell differentiation|
|heme binding|
|limb morphogenesis|
|appendage morphogenesis|
|meiotic nuclear division|
|regulation of muscle cell differentiation|
|intracellular receptor signaling pathway|
|meiotic cell cycle process|
|regulation of lymphocyte differentiation|
|limb development|
|appendage development|
|cellular response to xenobiotic stimulus|
|cellular lipid catabolic process|
|establishment or maintenance of cell polarity|
|bone development|
|hormone metabolic process|
|cellular response to acid chemical|
|response to nutrient|
|meiotic cell cycle|
|keratinization|
|T cell activation|
|skeletal system morphogenesis|
|cell fate commitment|
|sensory organ morphogenesis|
|steroid metabolic process|
|carboxylic acid catabolic process|
|organic acid catabolic process|
|kidney development|
|regulation of leukocyte differentiation|
|keratinocyte differentiation|
|renal system development|
|nuclear division|
|lipid catabolic process|
|response to xenobiotic stimulus|
|organelle fission|
|epidermal cell differentiation|
|regulation of T cell activation|
|urogenital system development|
|multicellular organismal homeostasis|
|regionalization|
|response to acid chemical|
|cellular process involved in reproduction in multicellular organism|
|lymphocyte activation|
|skin development|
|epidermis development|
|pattern specification process|
|small molecule catabolic process|
|regulation of hemopoiesis|
|organic hydroxy compound metabolic process|
|skeletal system development|
|regulation of body fluid levels|
|inflammatory response|
|response to nutrient levels|
|regulation of lymphocyte activation|
|cellular response to lipid|
|monocarboxylic acid metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|spermatogenesis|
|sensory organ development|
|male gamete generation|
|embryonic morphogenesis|
|regulation of leukocyte activation|
|regulation of cell activation|
|epithelial cell differentiation|
|gamete generation|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|response to lipid|
|carboxylic acid metabolic process|
|leukocyte activation|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|animal organ morphogenesis|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|embryo development|
|multi-organism reproductive process|
|cell cycle process|
|oxoacid metabolic process|
|organic acid metabolic process|
|programmed cell death|
|cellular response to oxygen-containing compound|
|cell activation|
|cell death|
|chemical homeostasis|
|epithelium development|
|lipid metabolic process|
|negative regulation of signal transduction|
|cell cycle|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|homeostatic process|
|regulation of immune system process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp121|Golgicide-A 2μM R03 exp121]]|-1.77|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|-1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15935
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.8 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP26B1 Expression in NALM6 Cells: -3.8'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>