======= CYP26C1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP26C1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 26 subfamily C member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=340665|340665]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6V0L0|Q6V0L0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP26C1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP26C1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608428|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme is involved in the catabolism of all-trans- and 9-cis-retinoic acid, and thus contributes to the regulation of retinoic acid levels in cells and tissues. This gene is adjacent to a related gene on chromosome 10q23.33. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retinoic acid catabolic process|
|diterpenoid catabolic process|
|terpenoid catabolic process|
|fat-soluble vitamin catabolic process|
|negative regulation of retinoic acid receptor signaling pathway|
|isoprenoid catabolic process|
|retinoic acid 4-hydroxylase activity|
|vitamin catabolic process|
|regulation of retinoic acid receptor signaling pathway|
|retinoic acid binding|
|retinoic acid metabolic process|
|fat-soluble vitamin metabolic process|
|neural crest cell development|
|stem cell development|
|mesenchymal cell development|
|neural crest cell differentiation|
|organelle fusion|
|retinoid metabolic process|
|diterpenoid metabolic process|
|monocarboxylic acid catabolic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|vitamin metabolic process|
|iron ion binding|
|sterol metabolic process|
|isoprenoid metabolic process|
|heme binding|
|mesenchymal cell differentiation|
|stem cell differentiation|
|cellular lipid catabolic process|
|hormone metabolic process|
|anterior/posterior pattern specification|
|mesenchyme development|
|steroid metabolic process|
|organic acid catabolic process|
|carboxylic acid catabolic process|
|lipid catabolic process|
|regionalization|
|pattern specification process|
|small molecule catabolic process|
|organic hydroxy compound metabolic process|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|central nervous system development|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of response to stimulus|
|cell development|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp31|Rifampicin 1μM R00 exp31]]|-1.86|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14467
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP26C1 Expression in NALM6 Cells: -2.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>