======= CYP27B1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP27B1
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 27 subfamily B member 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1594|1594]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O15528|O15528]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP27B1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP27B1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609506|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position. This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D3) to 1-alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)(2)D3), and of 24,25-dihydroxyvitamin D3 (24,25(OH)(2)D3) to 1- alpha,24,25-trihydroxyvitamin D3 (1alpha,24,25(OH)(3)D3). Is also active with 25-hydroxy-24-oxo-vitamin D3. Plays an important role in normal bone growth, calcium metabolism, and tissue differentiation. {ECO:0000269|PubMed:10518789}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcidiol 1-monooxygenase activity|
|positive regulation of vitamin D receptor signaling pathway|
|regulation of vitamin D 24-hydroxylase activity|
|vitamin D catabolic process|
|negative regulation of calcidiol 1-monooxygenase activity|
|positive regulation of vitamin D 24-hydroxylase activity|
|vitamin D biosynthetic process|
|calcitriol biosynthetic process from calciol|
|vitamin D3 metabolic process|
|negative regulation of vitamin D biosynthetic process|
|negative regulation of vitamin metabolic process|
|regulation of vitamin D receptor signaling pathway|
|positive regulation of response to nutrient levels|
|positive regulation of response to extracellular stimulus|
|cellular alcohol metabolic process|
|cellular alcohol biosynthetic process|
|fat-soluble vitamin biosynthetic process|
|regulation of calcidiol 1-monooxygenase activity|
|G1 to G0 transition|
|regulation of vitamin D biosynthetic process|
|fat-soluble vitamin catabolic process|
|negative regulation of hormone biosynthetic process|
|negative regulation of hormone metabolic process|
|negative regulation of monooxygenase activity|
|vitamin catabolic process|
|regulation of vitamin metabolic process|
|negative regulation of alcohol biosynthetic process|
|vitamin D metabolic process|
|positive regulation of keratinocyte differentiation|
|vitamin biosynthetic process|
|negative regulation of steroid biosynthetic process|
|negative regulation of oxidoreductase activity|
|decidualization|
|positive regulation of epidermal cell differentiation|
|negative regulation of steroid metabolic process|
|regulation of response to nutrient levels|
|regulation of response to extracellular stimulus|
|steroid catabolic process|
|regulation of hormone biosynthetic process|
|response to vitamin D|
|maternal placenta development|
|fat-soluble vitamin metabolic process|
|regulation of hormone metabolic process|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|steroid hormone biosynthetic process|
|bone mineralization|
|negative regulation of lipid biosynthetic process|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|positive regulation of epithelial cell differentiation|
|polyol biosynthetic process|
|regulation of epidermal cell differentiation|
|hormone biosynthetic process|
|maternal process involved in female pregnancy|
|regulation of bone mineralization|
|regulation of alcohol biosynthetic process|
|organic hydroxy compound catabolic process|
|response to estrogen|
|negative regulation of lipid metabolic process|
|regulation of epidermis development|
|response to vitamin|
|regulation of steroid biosynthetic process|
|negative regulation of small molecule metabolic process|
|biomineral tissue development|
|regulation of biomineral tissue development|
|biomineralization|
|regulation of biomineralization|
|regulation of oxidoreductase activity|
|polyol metabolic process|
|alcohol biosynthetic process|
|regulation of steroid metabolic process|
|vitamin metabolic process|
|steroid biosynthetic process|
|secondary alcohol metabolic process|
|iron ion binding|
|regulation of epithelial cell differentiation|
|heme binding|
|placenta development|
|mitochondrial outer membrane|
|female pregnancy|
|response to interferon-gamma|
|negative regulation of cell growth|
|organic hydroxy compound biosynthetic process|
|regulation of lipid biosynthetic process|
|regulation of ossification|
|hormone metabolic process|
|multi-multicellular organism process|
|response to nutrient|
|negative regulation of growth|
|calcium ion transport|
|steroid metabolic process|
|ossification|
|divalent metal ion transport|
|lipid catabolic process|
|divalent inorganic cation transport|
|response to lipopolysaccharide|
|alcohol metabolic process|
|response to molecule of bacterial origin|
|regulation of lipid metabolic process|
|regulation of cell growth|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|small molecule catabolic process|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|organic cyclic compound catabolic process|
|divalent inorganic cation homeostasis|
|response to nutrient levels|
|drug metabolic process|
|response to extracellular stimulus|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|positive regulation of response to external stimulus|
|metal ion homeostasis|
|metal ion transport|
|developmental process involved in reproduction|
|regulation of growth|
|negative regulation of cell population proliferation|
|response to bacterium|
|cation homeostasis|
|inorganic ion homeostasis|
|innate immune response|
|ion homeostasis|
|negative regulation of catalytic activity|
|multicellular organismal reproductive process|
|cation transport|
|multicellular organism reproduction|
|response to lipid|
|response to organic cyclic compound|
|defense response to other organism|
|oxidation-reduction process|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|cell cycle process|
|regulation of response to external stimulus|
|response to cytokine|
|chemical homeostasis|
|negative regulation of molecular function|
|lipid metabolic process|
|mitochondrion|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|defense response|
|positive regulation of developmental process|
|ion transport|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|-1.96|
|[[:results:exp72|LB-100 4.1μM R02 exp72]]|-1.87|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6186
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.83 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP27B1 Expression in NALM6 Cells: 3.83'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>