======= CYP2D6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: CYP2D6
  * **<color #00a2e8>Official Name</color>**: cytochrome P450 family 2 subfamily D member 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1565|1565]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P10635|P10635]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=CYP2D6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20CYP2D6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/124030|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. {ECO:0000269|PubMed:16352597}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|p450|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of cellular organofluorine metabolic process|
|negative regulation of cellular organofluorine metabolic process|
|negative regulation of cellular organohalogen metabolic process|
|regulation of cellular organohalogen metabolic process|
|alkaloid catabolic process|
|isoquinoline alkaloid metabolic process|
|monoterpenoid metabolic process|
|alkaloid metabolic process|
|coumarin metabolic process|
|phenylpropanoid metabolic process|
|oxidative demethylation|
|exogenous drug catabolic process|
|long-chain fatty acid biosynthetic process|
|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|
|monooxygenase activity|
|estrogen metabolic process|
|steroid hydroxylase activity|
|retinol metabolic process|
|secondary metabolic process|
|arachidonic acid metabolic process|
|drug binding|
|demethylation|
|primary alcohol metabolic process|
|retinoid metabolic process|
|unsaturated fatty acid metabolic process|
|diterpenoid metabolic process|
|icosanoid metabolic process|
|long-chain fatty acid metabolic process|
|oxidoreductase activity|
|fatty acid biosynthetic process|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|xenobiotic metabolic process|
|iron ion binding|
|isoprenoid metabolic process|
|heme binding|
|drug catabolic process|
|fatty acid derivative metabolic process|
|negative regulation of binding|
|monocarboxylic acid biosynthetic process|
|cellular response to xenobiotic stimulus|
|hormone metabolic process|
|steroid metabolic process|
|response to xenobiotic stimulus|
|carboxylic acid biosynthetic process|
|organic acid biosynthetic process|
|alcohol metabolic process|
|fatty acid metabolic process|
|regulation of binding|
|cellular nitrogen compound catabolic process|
|organic hydroxy compound metabolic process|
|drug metabolic process|
|monocarboxylic acid metabolic process|
|regulation of hormone levels|
|lipid biosynthetic process|
|small molecule biosynthetic process|
|intracellular membrane-bounded organelle|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|cellular lipid metabolic process|
|oxidation-reduction process|
|oxoacid metabolic process|
|endoplasmic reticulum|
|response to drug|
|organic acid metabolic process|
|organonitrogen compound catabolic process|
|negative regulation of molecular function|
|lipid metabolic process|
|mitochondrion|
|small molecule metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16511
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.49 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='CYP2D6 Expression in NALM6 Cells: 1.49'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>