======= DAND5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DAND5
  * **<color #00a2e8>Official Name</color>**: DAN domain BMP antagonist family member 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=199699|199699]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N907|Q8N907]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DAND5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DAND5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609068|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DAN|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|sequestering of nodal from receptor via nodal binding|
|negative regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|negative regulation of nodal signaling pathway involved in determination of left/right asymmetry|
|negative regulation of nodal signaling pathway|
|sequestering of BMP in extracellular matrix|
|regulation of nodal signaling pathway involved in determination of left/right asymmetry|
|regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|determination of left/right asymmetry in lateral mesoderm|
|morphogen activity|
|maintenance of protein location in extracellular region|
|regulation of nodal signaling pathway|
|negative regulation of mesoderm development|
|sequestering of extracellular ligand from receptor|
|negative regulation of activin receptor signaling pathway|
|extracellular negative regulation of signal transduction|
|extracellular regulation of signal transduction|
|lateral mesoderm development|
|regulation of mesoderm development|
|signal transduction involved in regulation of gene expression|
|atrial septum development|
|regulation of activin receptor signaling pathway|
|cardiac atrium development|
|negative regulation of BMP signaling pathway|
|determination of heart left/right asymmetry|
|ventricular septum development|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of BMP signaling pathway|
|maintenance of protein location|
|cardiac septum development|
|regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|mesoderm development|
|specification of symmetry|
|cardiac ventricle development|
|negative regulation of cellular response to growth factor stimulus|
|maintenance of location|
|protein localization to extracellular region|
|cardiac chamber development|
|mesenchyme development|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to growth factor stimulus|
|pattern specification process|
|heart development|
|circulatory system development|
|negative regulation of developmental process|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|extracellular space|
|negative regulation of response to stimulus|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.512|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.42|
|[[:human genes:p:psmb4|PSMB4]]|0.409|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.406|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.406|
|[[:human genes:t:tceb3c|TCEB3C]]|0.405|
|[[:human genes:r:rnf113a|RNF113A]]|0.403|
|[[:human genes:t:twistnb|TWISTNB]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2821
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DAND5 Expression in NALM6 Cells: 1.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>