======= DBN1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DBN1
  * **<color #00a2e8>Official Name</color>**: drebrin 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1627|1627]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16643|Q16643]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DBN1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DBN1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/126660|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS. {ECO:0000269|PubMed:20215400}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Cofilin ADF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell communication by chemical coupling|
|positive regulation of receptor localization to synapse|
|site of polarized growth|
|positive regulation of protein localization to synapse|
|positive regulation of synaptic plasticity|
|profilin binding|
|postsynaptic actin cytoskeleton organization|
|actomyosin|
|postsynaptic cytoskeleton organization|
|gap junction|
|regulation of receptor localization to synapse|
|postsynaptic cytosol|
|cell communication by electrical coupling|
|cortical cytoskeleton|
|positive regulation of dendritic spine morphogenesis|
|cytoplasmic sequestering of protein|
|regulation of protein localization to synapse|
|positive regulation of dendrite morphogenesis|
|regulation of dendritic spine morphogenesis|
|positive regulation of axon extension|
|positive regulation of dendritic spine development|
|cortical actin cytoskeleton|
|regulation of neuronal synaptic plasticity|
|regulation of dendritic spine development|
|positive regulation of dendrite development|
|neural precursor cell proliferation|
|maintenance of protein location in cell|
|actin filament|
|positive regulation of axonogenesis|
|postsynapse organization|
|regulation of dendrite morphogenesis|
|maintenance of location in cell|
|regulation of axon extension|
|regulation of postsynapse organization|
|maintenance of protein location|
|regulation of extent of cell growth|
|growth cone|
|regulation of dendrite development|
|positive regulation of cell morphogenesis involved in differentiation|
|positive regulation of cell growth|
|maintenance of location|
|regulation of actin filament polymerization|
|positive regulation of developmental growth|
|lamellipodium|
|regulation of cell size|
|regulation of actin polymerization or depolymerization|
|regulation of actin filament length|
|regulation of axonogenesis|
|regulation of synaptic plasticity|
|postsynaptic membrane|
|actin filament binding|
|actin cytoskeleton|
|regulation of synapse organization|
|regulation of protein polymerization|
|regulation of synapse structure or activity|
|actin filament organization|
|postsynaptic density|
|positive regulation of growth|
|regulation of actin filament organization|
|actin binding|
|synapse organization|
|positive regulation of neuron projection development|
|regulation of cell morphogenesis involved in differentiation|
|cadherin binding|
|regulation of developmental growth|
|regulation of actin cytoskeleton organization|
|glutamatergic synapse|
|regulation of supramolecular fiber organization|
|cytoskeleton|
|positive regulation of neuron differentiation|
|regulation of cellular component size|
|in utero embryonic development|
|positive regulation of cell projection organization|
|regulation of actin filament-based process|
|regulation of cell growth|
|dendrite|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|regulation of protein complex assembly|
|supramolecular fiber organization|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|regulation of cell morphogenesis|
|cell projection morphogenesis|
|actin cytoskeleton organization|
|regulation of neuron projection development|
|cell part morphogenesis|
|regulation of anatomical structure size|
|positive regulation of nervous system development|
|regulation of cytoskeleton organization|
|positive regulation of cell development|
|cell population proliferation|
|actin filament-based process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|cell morphogenesis|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|embryo development|
|neuron differentiation|
|regulation of protein localization|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|positive regulation of developmental process|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.88|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9514
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DBN1 Expression in NALM6 Cells: 7.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>