======= DDB1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDB1
  * **<color #00a2e8>Official Name</color>**: damage specific DNA binding protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1642|1642]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16531|Q16531]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDB1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDB1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600045|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for DNA repair. Binds to DDB2 to form the UV- damaged DNA-binding protein complex (the UV-DDB complex). The UV- DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts (6-4 PP), apurinic sites and short mismatches. Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin- protein ligase complex is determined by the variable substrate recognition component recruited by DDB1. DCX(DDB2) (also known as DDB1-CUL4-ROC1, CUL4-DDB-ROC1 and CUL4-DDB-RBX1) may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. DCX(DDB2) also ubiquitinates XPC, which may enhance DNA-binding by XPC and promote NER. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. DCX(ERCC8) (the CSA complex) plays a role in transcription-coupled repair (TCR). May also play a role in ubiquitination of CDKN1B/p27kip when associated with CUL4 and SKP2. {ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:14739464, ECO:0000269|PubMed:15448697, ECO:0000269|PubMed:15882621, ECO:0000269|PubMed:16260596, ECO:0000269|PubMed:16407242, ECO:0000269|PubMed:16407252, ECO:0000269|PubMed:16473935, ECO:0000269|PubMed:16482215, ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:16940174, ECO:0000269|PubMed:17041588, ECO:0000269|PubMed:17079684, ECO:0000269|PubMed:18332868, ECO:0000269|PubMed:18381890, ECO:0000269|PubMed:18593899, ECO:0000269|PubMed:19966799, ECO:0000269|PubMed:22118460, ECO:0000269|PubMed:25043012, ECO:0000269|PubMed:25108355}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CPSF A|
|MMS1 N|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation by virus of viral protein levels in host cell|
|WD40-repeat domain binding|
|Cul4B-RING E3 ubiquitin ligase complex|
|regulation by virus of viral protein levels in host cell|
|Cul4A-RING E3 ubiquitin ligase complex|
|positive regulation of gluconeogenesis|
|UV-damage excision repair|
|positive regulation of viral release from host cell|
|cullin family protein binding|
|histone H2A monoubiquitination|
|nucleotide-excision repair, preincision complex stabilization|
|nucleotide-excision repair, DNA incision, 3-to lesion|
|nucleotide-excision repair, DNA duplex unwinding|
|nucleotide-excision repair, DNA damage recognition|
|histone H2A ubiquitination|
|global genome nucleotide-excision repair|
|Cul4-RING E3 ubiquitin ligase complex|
|nucleotide-excision repair, preincision complex assembly|
|histone monoubiquitination|
|regulation of viral release from host cell|
|positive regulation of viral genome replication|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|positive regulation of glucose metabolic process|
|DNA damage response, detection of DNA damage|
|histone ubiquitination|
|nucleotide-excision repair, DNA incision|
|regulation of gluconeogenesis|
|damaged DNA binding|
|positive regulation of cellular carbohydrate metabolic process|
|positive regulation of viral life cycle|
|protein monoubiquitination|
|transcription-coupled nucleotide-excision repair|
|interaction with symbiont|
|positive regulation of carbohydrate metabolic process|
|protein binding, bridging|
|cellular response to UV|
|regulation of viral genome replication|
|regulation of carbohydrate biosynthetic process|
|positive regulation of viral process|
|nuclear chromosome, telomeric region|
|nucleotide-excision repair|
|DNA duplex unwinding|
|cellular response to light stimulus|
|regulation of glucose metabolic process|
|regulation of circadian rhythm|
|DNA geometric change|
|positive regulation of small molecule metabolic process|
|regulation of cellular carbohydrate metabolic process|
|response to UV|
|regulation of viral life cycle|
|cellular response to radiation|
|protein-DNA complex assembly|
|regulation of carbohydrate metabolic process|
|regulation of viral process|
|positive regulation of protein catabolic process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|protein-DNA complex subunit organization|
|positive regulation of protein complex assembly|
|protein-containing complex binding|
|rhythmic process|
|DNA conformation change|
|nucleic acid phosphodiester bond hydrolysis|
|response to light stimulus|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|post-translational protein modification|
|histone modification|
|covalent chromatin modification|
|regulation of protein catabolic process|
|regulation of mitotic cell cycle phase transition|
|regulation of small molecule metabolic process|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|positive regulation of catabolic process|
|response to radiation|
|regulation of cell cycle phase transition|
|regulation of protein complex assembly|
|positive regulation of multi-organism process|
|DNA repair|
|positive regulation of cellular component biogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|regulation of mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|detection of stimulus|
|chromatin organization|
|viral process|
|DNA metabolic process|
|regulation of cell cycle process|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|regulation of cellular component biogenesis|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|negative regulation of cell death|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|chemical homeostasis|
|cell-cell signaling|
|response to abiotic stimulus|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|proteolysis|
|DNA binding|
|regulation of apoptotic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|extracellular space|
|homeostatic process|
|regulation of cell death|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|protein-containing complex subunit organization|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.91|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|-1.84|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-1.74|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.72|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.74|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|1.76|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.83|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 724/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|28/28|
|blood|28/28|
|bone|25/25|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|15/15|
|kidney|21/21|
|liver|20/20|
|lung|75/75|
|lymphocyte|14/14|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|7/7|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 988
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDB1 Expression in NALM6 Cells: 8.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>