======= DDI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDI2
  * **<color #00a2e8>Official Name</color>**: DNA damage inducible 1 homolog 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84301|84301]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TDH0|Q5TDH0]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620871|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane (PubMed:27676298, PubMed:27528193). Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1 (PubMed:27528193). {ECO:0000269|PubMed:27528193, ECO:0000269|PubMed:27676298}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RVP|
|Asp protease|
|RVP 2|
|ubiquitin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of DNA stability|
|cellular response to hydroxyurea|
|response to hydroxyurea|
|response to antimetabolite|
|aspartic-type endopeptidase activity|
|ubiquitin binding|
|response to antineoplastic agent|
|chromosome|
|protein processing|
|cellular response to inorganic substance|
|protein maturation|
|regulation of protein stability|
|proteasomal protein catabolic process|
|cellular response to drug|
|response to inorganic substance|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|cellular response to nitrogen compound|
|protein catabolic process|
|cellular macromolecule catabolic process|
|response to drug|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to nitrogen compound|
|proteolysis|
|organic substance catabolic process|
|cellular catabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-3.76|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-3.55|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.84|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.6|
|[[:results:exp449|Arsenic trioxide 60μM R08 exp449]]|-2.55|
|[[:results:exp182|IU1-47 25μM R04 exp182]]|-2.52|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.29|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.29|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.99|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-1.73|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|1.7|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.88|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.91|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.91|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.94|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|2.3|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.45|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.64|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|2.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:ngly1|NGLY1]]|0.683|
|[[:human genes:n:nfe2l1|NFE2L1]]|0.57|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 8/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|2/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1455
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDI2 Expression in NALM6 Cells: 7.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>