======= DDR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDR1
  * **<color #00a2e8>Official Name</color>**: discoidin domain receptor tyrosine kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=780|780]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q08345|Q08345]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600408|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase|
|F5 F8 type C|
|Pkinase Tyr|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein tyrosine kinase collagen receptor activity|
|smooth muscle cell-matrix adhesion|
|smooth muscle cell migration|
|collagen-activated tyrosine kinase receptor signaling pathway|
|collagen-activated signaling pathway|
|regulation of extracellular matrix disassembly|
|mammary gland alveolus development|
|mammary gland lobule development|
|muscle cell migration|
|branching involved in mammary gland duct morphogenesis|
|epiboly involved in wound healing|
|wound healing, spreading of cells|
|epiboly|
|mammary gland duct morphogenesis|
|peptidyl-tyrosine autophosphorylation|
|embryo implantation|
|regulation of extracellular matrix organization|
|mammary gland morphogenesis|
|lactation|
|morphogenesis of an epithelial sheet|
|transmembrane receptor protein tyrosine kinase activity|
|mammary gland epithelium development|
|neuron projection extension|
|collagen binding|
|body fluid secretion|
|developmental cell growth|
|cell growth|
|gland morphogenesis|
|developmental growth involved in morphogenesis|
|regulation of cell-matrix adhesion|
|cell-matrix adhesion|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|morphogenesis of a branching epithelium|
|morphogenesis of a branching structure|
|female pregnancy|
|cell-substrate adhesion|
|protein autophosphorylation|
|receptor complex|
|regulation of cell-substrate adhesion|
|multi-multicellular organism process|
|ear development|
|epithelial tube morphogenesis|
|extracellular matrix organization|
|extracellular structure organization|
|developmental growth|
|growth|
|axon development|
|gland development|
|regulation of cell growth|
|morphogenesis of an epithelium|
|wound healing|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|cell part morphogenesis|
|sensory organ development|
|tissue morphogenesis|
|response to wounding|
|tube morphogenesis|
|neuron projection development|
|regulation of growth|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|tube development|
|peptidyl-amino acid modification|
|positive regulation of cell population proliferation|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|cell migration|
|protein phosphorylation|
|multi-organism reproductive process|
|neuron differentiation|
|cell motility|
|localization of cell|
|epithelium development|
|secretion|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|phosphorylation|
|locomotion|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|ATP binding|
|generation of neurons|
|movement of cell or subcellular component|
|extracellular space|
|regulation of cell population proliferation|
|neurogenesis|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5549
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDR1 Expression in NALM6 Cells: 5.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>