======= DDX39A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX39A
  * **<color #00a2e8>Official Name</color>**: DExD-box helicase 39A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10212|10212]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O00148|O00148]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX39A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX39A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619906|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the DEAD box protein family. These proteins are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene is thought to play a role in the prognosis of patients with gastrointestinal stromal tumors. A pseudogene of this gene is present on chromosome 13. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Isoform 1: Involved in pre-mRNA splicing. Required for the export of mRNA out of the nucleus. {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|transcription export complex|
|RNA helicase activity|
|mRNA 3-end processing|
|mRNA export from nucleus|
|mRNA-containing ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex export from nucleus|
|ribonucleoprotein complex localization|
|RNA export from nucleus|
|RNA 3-end processing|
|protein export from nucleus|
|mRNA transport|
|nuclear export|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|ATPase activity|
|nucleobase-containing compound transport|
|protein-containing complex localization|
|nucleocytoplasmic transport|
|nuclear transport|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|nuclear speck|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|intracellular protein transport|
|identical protein binding|
|RNA binding|
|ATP binding|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|RNA metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|-3.09|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.93|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-2.65|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.58|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.48|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-2.38|
|[[:results:exp249|Vinorelbine 0.001μM R05 exp249]]|-2.35|
|[[:results:exp235|Geldanamycin 0.01μM R05 exp235]]|-2.34|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-2.29|
|[[:results:exp302|35°C R06 exp302]]|-2.26|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.15|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.08|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-2.07|
|[[:results:exp142|OICR-9429 10μM R03 exp142]]|-2.06|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.05|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.04|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-2|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.98|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.95|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-1.93|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.92|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.89|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.86|
|[[:results:exp14|Cycloheximide 0.02μM R00 exp14]]|-1.84|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.81|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.8|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.77|
|[[:results:exp481|Ethambutol 25μM R08 exp481]]|-1.72|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.71|
|[[:results:exp73|LJH685 5μM R02 exp73]]|-1.71|
|[[:results:exp16|DABN 2μM R00 exp16]]|-1.7|
|[[:results:exp79|Q15 2.7μM R02 exp79]]|1.74|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|1.74|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.76|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.79|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|1.8|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.88|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.9|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|2.02|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|2.03|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.07|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.16|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.29|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.48|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.58|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.67|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|2.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpia|RPIA]]|0.576|
|[[:human genes:g:gemin6|GEMIN6]]|0.541|
|[[:human genes:t:thg1l|THG1L]]|0.54|
|[[:human genes:v:vezt|VEZT]]|0.504|
|[[:human genes:f:fh|FH]]|0.5|
|[[:human genes:g:gemin8|GEMIN8]]|0.493|
|[[:human genes:a:atxn10|ATXN10]]|0.482|
|[[:human genes:g:gemin7|GEMIN7]]|0.48|
|[[:human genes:t:ten1|TEN1]]|0.472|
|[[:human genes:r:rfk|RFK]]|0.471|
|[[:human genes:a:alg1|ALG1]]|0.47|
|[[:human genes:p:pmm2|PMM2]]|0.47|
|[[:human genes:p:ppcdc|PPCDC]]|0.463|
|[[:human genes:p:pmvk|PMVK]]|0.458|
|[[:human genes:l:lsm10|LSM10]]|0.457|
|[[:human genes:t:ttc4|TTC4]]|0.455|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.451|
|[[:human genes:r:rpp21|RPP21]]|0.451|
|[[:human genes:p:ppcs|PPCS]]|0.451|
|[[:human genes:u:uhrf1|UHRF1]]|0.448|
|[[:human genes:d:dnlz|DNLZ]]|0.448|
|[[:human genes:p:ppa1|PPA1]]|0.448|
|[[:human genes:g:g6pd|G6PD]]|0.443|
|[[:human genes:r:rptor|RPTOR]]|0.44|
|[[:human genes:t:trmt61a|TRMT61A]]|0.438|
|[[:human genes:p:pelo|PELO]]|0.437|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.435|
|[[:human genes:g:gemin4|GEMIN4]]|0.432|
|[[:human genes:p:pgm3|PGM3]]|0.43|
|[[:human genes:s:slc25a19|SLC25A19]]|0.43|
|[[:human genes:d:dohh|DOHH]]|0.43|
|[[:human genes:t:tubd1|TUBD1]]|0.43|
|[[:human genes:e:elp2|ELP2]]|0.428|
|[[:human genes:d:dpagt1|DPAGT1]]|0.427|
|[[:human genes:r:rabggtb|RABGGTB]]|0.426|
|[[:human genes:d:dhrsx|DHRSX]]|0.426|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.426|
|[[:human genes:n:n6amt1|N6AMT1]]|0.424|
|[[:human genes:t:tsen54|TSEN54]]|0.423|
|[[:human genes:s:sepsecs|SEPSECS]]|0.421|
|[[:human genes:a:atp2b1|ATP2B1]]|0.419|
|[[:human genes:c:c15orf41|C15orf41]]|0.417|
|[[:human genes:g:gmppb|GMPPB]]|0.417|
|[[:human genes:h:hccs|HCCS]]|0.416|
|[[:human genes:d:dhps|DHPS]]|0.416|
|[[:human genes:a:aspm|ASPM]]|0.416|
|[[:human genes:c:c1d|C1D]]|0.414|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.414|
|[[:human genes:p:ppp6c|PPP6C]]|0.414|
|[[:human genes:m:mrps5|MRPS5]]|0.412|
|[[:human genes:t:txnrd1|TXNRD1]]|0.408|
|[[:human genes:a:alg13|ALG13]]|0.408|
|[[:human genes:u:uap1|UAP1]]|0.406|
|[[:human genes:z:zzz3|ZZZ3]]|0.405|
|[[:human genes:n:ncdn|NCDN]]|0.404|
|[[:human genes:d:ddx20|DDX20]]|0.404|
|[[:human genes:t:taf1a|TAF1A]]|0.402|
|[[:human genes:s:srd5a3|SRD5A3]]|0.4|
|[[:human genes:a:atic|ATIC]]|0.4|
|[[:human genes:p:ptar1|PTAR1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1291
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.15 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX39A Expression in NALM6 Cells: 8.15'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>