======= DDX5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DDX5
  * **<color #00a2e8>Official Name</color>**: DEAD-box helicase 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1655|1655]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P17844|P17844]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DDX5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DDX5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/180630|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. {ECO:0000269|PubMed:12527917, ECO:0000269|PubMed:15298701, ECO:0000269|PubMed:15660129, ECO:0000269|PubMed:17011493, ECO:0000269|PubMed:17960593, ECO:0000269|PubMed:18829551, ECO:0000269|PubMed:19718048, ECO:0000269|PubMed:21343338}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DEAD|
|P68HR|
|Helicase C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|MH2 domain binding|
|primary miRNA binding|
|pri-miRNA transcription by RNA polymerase II|
|positive regulation of production of miRNAs involved in gene silencing by miRNA|
|pre-mRNA binding|
|positive regulation of DNA damage response, signal transduction by p53 class mediator|
|alternative mRNA splicing, via spliceosome|
|regulation of skeletal muscle cell differentiation|
|regulation of production of miRNAs involved in gene silencing by miRNA|
|regulation of production of small RNA involved in gene silencing by RNA|
|intracellular estrogen receptor signaling pathway|
|positive regulation of signal transduction by p53 class mediator|
|R-SMAD binding|
|positive regulation of gene silencing by miRNA|
|positive regulation of posttranscriptional gene silencing|
|mRNA transcription|
|regulation of androgen receptor signaling pathway|
|ribonucleoprotein complex binding|
|regulation of DNA damage response, signal transduction by p53 class mediator|
|myoblast differentiation|
|androgen receptor signaling pathway|
|regulation of pri-miRNA transcription by RNA polymerase II|
|androgen receptor binding|
|promoter-specific chromatin binding|
|regulation of skeletal muscle tissue development|
|intrinsic apoptotic signaling pathway by p53 class mediator|
|SMAD binding|
|calcium-dependent protein binding|
|RNA helicase activity|
|regulation of alternative mRNA splicing, via spliceosome|
|intracellular steroid hormone receptor signaling pathway|
|epithelial to mesenchymal transition|
|mRNA 3-UTR binding|
|regulation of intracellular steroid hormone receptor signaling pathway|
|catalytic step 2 spliceosome|
|regulation of gene silencing by miRNA|
|regulation of posttranscriptional gene silencing|
|BMP signaling pathway|
|regulation of gene silencing by RNA|
|regulation of viral genome replication|
|positive regulation of response to DNA damage stimulus|
|regulation of mRNA splicing, via spliceosome|
|response to BMP|
|cellular response to BMP stimulus|
|regulation of osteoblast differentiation|
|steroid hormone mediated signaling pathway|
|signal transduction by p53 class mediator|
|regulation of gene silencing|
|regulation of striated muscle tissue development|
|regulation of muscle tissue development|
|regulation of muscle organ development|
|regulation of RNA splicing|
|regulation of mRNA processing|
|regulation of viral life cycle|
|intrinsic apoptotic signaling pathway|
|ribonucleoprotein complex|
|mesenchymal cell differentiation|
|intracellular receptor signaling pathway|
|hormone-mediated signaling pathway|
|regulation of signal transduction by p53 class mediator|
|cellular response to steroid hormone stimulus|
|regulation of ossification|
|nuclear-transcribed mRNA catabolic process|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|calmodulin binding|
|regulation of viral process|
|mRNA catabolic process|
|regulation of response to DNA damage stimulus|
|regulation of symbiosis, encompassing mutualism through parasitism|
|mesenchyme development|
|RNA catabolic process|
|rhythmic process|
|apoptotic signaling pathway|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|response to steroid hormone|
|regulation of mRNA metabolic process|
|enzyme binding|
|nucleobase-containing compound catabolic process|
|RNA splicing|
|heterocycle catabolic process|
|cellular nitrogen compound catabolic process|
|aromatic compound catabolic process|
|muscle structure development|
|mRNA processing|
|organic cyclic compound catabolic process|
|transcription by RNA polymerase II|
|cellular response to growth factor stimulus|
|cellular response to lipid|
|response to growth factor|
|cellular response to organic cyclic compound|
|cellular response to hormone stimulus|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|mRNA metabolic process|
|enzyme linked receptor protein signaling pathway|
|regulation of cellular response to stress|
|regulation of multi-organism process|
|response to lipid|
|nucleolus|
|negative regulation of transcription by RNA polymerase II|
|RNA processing|
|cellular macromolecule catabolic process|
|response to hormone|
|response to organic cyclic compound|
|apoptotic process|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|programmed cell death|
|cell death|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|positive regulation of signal transduction|
|RNA metabolic process|
|intracellular signal transduction|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of gene expression|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp483|FTY720 3μM R08 exp483]]|-2.07|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.78|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.8|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|1.81|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|1.87|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|2.03|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|2.05|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.13|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|2.84|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|3.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:i:id3|ID3]]|0.484|
|[[:human genes:d:dnajc3|DNAJC3]]|0.478|
|[[:human genes:n:nsd1|NSD1]]|0.447|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.443|
|[[:human genes:t:taf5l|TAF5L]]|0.435|
|[[:human genes:a:alg5|ALG5]]|0.433|
|[[:human genes:u:ube2l3|UBE2L3]]|0.426|
|[[:human genes:f:fli1|FLI1]]|0.425|
|[[:human genes:s:scaf8|SCAF8]]|0.423|
|[[:human genes:m:manf|MANF]]|0.422|
|[[:human genes:a:asxl2|ASXL2]]|0.419|
|[[:human genes:a:atf7ip|ATF7IP]]|0.419|
|[[:human genes:s:setdb1|SETDB1]]|0.418|
|[[:human genes:b:bap1|BAP1]]|0.408|
|[[:human genes:b:brpf1|BRPF1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 62/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|3/28|
|blood|0/28|
|bone|0/25|
|breast|5/33|
|central nervous system|6/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|0/15|
|kidney|0/21|
|liver|2/20|
|lung|12/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|3/24|
|peripheral nervous system|1/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|3/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 900
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 10.72 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DDX5 Expression in NALM6 Cells: 10.72'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>