======= DERL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DERL2
  * **<color #00a2e8>Official Name</color>**: derlin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51009|51009]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9GZP9|Q9GZP9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DERL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DERL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610304|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189). May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:26565908}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DER1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|signal recognition particle receptor complex|
|signal recognition particle|
|Hrd1p ubiquitin ligase ERAD-L complex|
|negative regulation of retrograde protein transport, ER to cytosol|
|negative regulation of protein exit from endoplasmic reticulum|
|negative regulation of ERAD pathway|
|regulation of retrograde protein transport, ER to cytosol|
|suckling behavior|
|endoplasmic reticulum mannose trimming|
|ubiquitin-specific protease binding|
|endoplasmic reticulum to cytosol transport|
|retrograde protein transport, ER to cytosol|
|protein demannosylation|
|protein alpha-1,2-demannosylation|
|endoplasmic reticulum quality control compartment|
|protein exit from endoplasmic reticulum|
|misfolded protein binding|
|regulation of protein exit from endoplasmic reticulum|
|regulation of ERAD pathway|
|protein deglycosylation|
|negative regulation of intracellular protein transport|
|negative regulation of response to endoplasmic reticulum stress|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of intracellular transport|
|multi-organism behavior|
|ubiquitin-dependent ERAD pathway|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of response to endoplasmic reticulum stress|
|feeding behavior|
|negative regulation of cellular protein catabolic process|
|ERAD pathway|
|endoplasmic reticulum unfolded protein response|
|integral component of endoplasmic reticulum membrane|
|negative regulation of cellular protein localization|
|late endosome|
|cellular response to unfolded protein|
|negative regulation of protein catabolic process|
|cellular response to topologically incorrect protein|
|response to unfolded protein|
|positive regulation of cell growth|
|negative regulation of protein transport|
|regulation of proteasomal protein catabolic process|
|negative regulation of establishment of protein localization|
|response to topologically incorrect protein|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of intracellular protein transport|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|early endosome|
|response to endoplasmic reticulum stress|
|positive regulation of growth|
|negative regulation of catabolic process|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|regulation of intracellular transport|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|glycoprotein metabolic process|
|regulation of cell growth|
|negative regulation of transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|behavior|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of growth|
|protein catabolic process|
|regulation of protein transport|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|positive regulation of cell population proliferation|
|endoplasmic reticulum membrane|
|intracellular protein transport|
|regulation of catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|regulation of protein localization|
|carbohydrate derivative metabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|proteolysis|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-3.86|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|-3.79|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|-3.52|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|-3.5|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|-3.12|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-3.08|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.86|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.83|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-2.82|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-2.81|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-2.76|
|[[:results:exp504|MK2206 4μM R08 exp504]]|-2.63|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|-2.58|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.53|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.52|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-2.49|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.35|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-2.27|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-2.23|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.23|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.23|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.15|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.13|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-2.07|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-2.06|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.03|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-1.98|
|[[:results:exp344|Chlorpromazine 10μM R07 exp344]]|-1.95|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.95|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.9|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.85|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.83|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.82|
|[[:results:exp348|Cyclosporin-A 3μM R07 exp348]]|-1.82|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-1.81|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.8|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|-1.78|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.78|
|[[:results:exp289|Hydroxyurea 15μM R06 exp289]]|-1.76|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.75|
|[[:results:exp482|Fas-L 44ng/ml R08 exp482]]|-1.74|
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|-1.73|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-1.72|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.71|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.7|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|-1.7|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|-1.7|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|1.76|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.82|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|2.27|
|[[:results:exp539|42°C R08 exp539]]|2.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ube2j1|UBE2J1]]|0.602|
|[[:human genes:m:manf|MANF]]|0.602|
|[[:human genes:d:dnajc3|DNAJC3]]|0.563|
|[[:human genes:u:ube2g2|UBE2G2]]|0.504|
|[[:human genes:a:alg5|ALG5]]|0.499|
|[[:human genes:c:ccdc101|CCDC101]]|0.496|
|[[:human genes:d:derl1|DERL1]]|0.492|
|[[:human genes:e:eny2|ENY2]]|0.468|
|[[:human genes:g:gmppb|GMPPB]]|0.468|
|[[:human genes:x:xpo6|XPO6]]|0.464|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.453|
|[[:human genes:c:cbfb|CBFB]]|0.436|
|[[:human genes:s:slc35b1|SLC35B1]]|0.435|
|[[:human genes:d:dnajb11|DNAJB11]]|0.43|
|[[:human genes:g:gtf2i|GTF2I]]|0.426|
|[[:human genes:m:med16|MED16]]|0.421|
|[[:human genes:d:dpagt1|DPAGT1]]|0.421|
|[[:human genes:e:eif4e|EIF4E]]|0.418|
|[[:human genes:n:nxt1|NXT1]]|0.418|
|[[:human genes:m:mapk14|MAPK14]]|0.417|
|[[:human genes:r:rnmt|RNMT]]|0.414|
|[[:human genes:t:tmed10|TMED10]]|0.411|
|[[:human genes:r:rptor|RPTOR]]|0.411|
|[[:human genes:c:c1orf27|C1orf27]]|0.41|
|[[:human genes:v:vmp1|VMP1]]|0.409|
|[[:human genes:d:dad1|DAD1]]|0.403|
|[[:human genes:m:max|MAX]]|0.402|
|[[:human genes:t:tmem41b|TMEM41B]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 55/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|5/28|
|bone|2/26|
|breast|2/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|3/21|
|liver|4/20|
|lung|3/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|1/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1850
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DERL2 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>