======= DHRS3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHRS3
  * **<color #00a2e8>Official Name</color>**: dehydrogenase/reductase 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9249|9249]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75911|O75911]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHRS3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHRS3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612830|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH. {ECO:0000269|PubMed:9705317}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Polysacc synt 2|
|adh short|
|KR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of retinoic acid receptor signaling pathway|
|NADP-retinol dehydrogenase activity|
|regulation of retinoic acid receptor signaling pathway|
|photoreceptor outer segment membrane|
|retinol dehydrogenase activity|
|retinol metabolic process|
|nucleotide binding|
|cardiac septum morphogenesis|
|outflow tract morphogenesis|
|electron transfer activity|
|primary alcohol metabolic process|
|lipid droplet|
|roof of mouth development|
|retinoid metabolic process|
|cardiac septum development|
|diterpenoid metabolic process|
|bone morphogenesis|
|terpenoid metabolic process|
|cellular hormone metabolic process|
|cardiac chamber morphogenesis|
|isoprenoid metabolic process|
|cardiac chamber development|
|electron transport chain|
|regulation of ossification|
|bone development|
|hormone metabolic process|
|visual perception|
|sensory perception of light stimulus|
|skeletal system morphogenesis|
|heart morphogenesis|
|alcohol metabolic process|
|generation of precursor metabolites and energy|
|organic hydroxy compound metabolic process|
|skeletal system development|
|heart development|
|regulation of hormone levels|
|circulatory system development|
|endoplasmic reticulum membrane|
|animal organ morphogenesis|
|cellular lipid metabolic process|
|oxidation-reduction process|
|sensory perception|
|lipid metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|negative regulation of response to stimulus|
|small molecule metabolic process|
|system process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14796
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHRS3 Expression in NALM6 Cells: -3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>