======= DHRSX =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHRSX
  * **<color #00a2e8>Official Name</color>**: dehydrogenase/reductase X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=207063|207063]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N5I4|Q8N5I4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHRSX&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHRSX|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/301034|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in the positive regulation of starvation- induced autophagy (PubMed:25076851). {ECO:0000269|PubMed:25076851}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|adh short|
|Epimerase|
|KR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oxidoreductase activity|
|positive regulation of autophagy|
|regulation of autophagy|
|positive regulation of cellular catabolic process|
|positive regulation of catabolic process|
|regulation of cellular catabolic process|
|oxidation-reduction process|
|regulation of catabolic process|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.27|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|-2.26|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|-2.13|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|-2.11|
|[[:results:exp132|Metformin 40μM R03 exp132]]|-2.06|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.05|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-1.91|
|[[:results:exp286|HMS-I2 1μM R06 exp286]]|-1.79|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.73|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.75|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.75|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|1.76|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.77|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.79|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|1.85|
|[[:results:exp532|TIC10 10μM R08 exp532]]|1.96|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.05|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.17|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|2.21|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.3|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|2.32|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|2.42|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pgm3|PGM3]]|0.704|
|[[:human genes:s:srd5a3|SRD5A3]]|0.664|
|[[:human genes:t:trmt61a|TRMT61A]]|0.637|
|[[:human genes:p:pmvk|PMVK]]|0.636|
|[[:human genes:a:alg6|ALG6]]|0.623|
|[[:human genes:d:dolk|DOLK]]|0.617|
|[[:human genes:p:ppcdc|PPCDC]]|0.608|
|[[:human genes:a:alg8|ALG8]]|0.604|
|[[:human genes:y:yars2|YARS2]]|0.597|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.592|
|[[:human genes:k:kdsr|KDSR]]|0.588|
|[[:human genes:l:lsm10|LSM10]]|0.578|
|[[:human genes:s:srp14|SRP14]]|0.572|
|[[:human genes:m:mbtps2|MBTPS2]]|0.57|
|[[:human genes:m:mrpl21|MRPL21]]|0.567|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.562|
|[[:human genes:b:bcs1l|BCS1L]]|0.559|
|[[:human genes:a:alg1|ALG1]]|0.557|
|[[:human genes:s:sec62|SEC62]]|0.556|
|[[:human genes:s:sco2|SCO2]]|0.555|
|[[:human genes:u:uap1|UAP1]]|0.554|
|[[:human genes:t:thg1l|THG1L]]|0.553|
|[[:human genes:p:ppa2|PPA2]]|0.551|
|[[:human genes:d:dnlz|DNLZ]]|0.547|
|[[:human genes:d:dpagt1|DPAGT1]]|0.544|
|[[:human genes:r:rpia|RPIA]]|0.542|
|[[:human genes:m:mrpl23|MRPL23]]|0.539|
|[[:human genes:f:fh|FH]]|0.539|
|[[:human genes:t:ten1|TEN1]]|0.538|
|[[:human genes:p:pars2|PARS2]]|0.536|
|[[:human genes:m:mrps6|MRPS6]]|0.536|
|[[:human genes:d:dap3|DAP3]]|0.532|
|[[:human genes:f:fastkd5|FASTKD5]]|0.531|
|[[:human genes:r:rbfa|RBFA]]|0.527|
|[[:human genes:s:ssb|SSB]]|0.527|
|[[:human genes:p:pmm2|PMM2]]|0.526|
|[[:human genes:t:triap1|TRIAP1]]|0.523|
|[[:human genes:m:mrps34|MRPS34]]|0.523|
|[[:human genes:m:mrps11|MRPS11]]|0.522|
|[[:human genes:m:mrps5|MRPS5]]|0.521|
|[[:human genes:p:ppcs|PPCS]]|0.52|
|[[:human genes:t:trmt6|TRMT6]]|0.52|
|[[:human genes:d:dars2|DARS2]]|0.519|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.516|
|[[:human genes:m:mrps14|MRPS14]]|0.516|
|[[:human genes:s:selrc1|SELRC1]]|0.516|
|[[:human genes:a:atxn10|ATXN10]]|0.515|
|[[:human genes:p:ptpmt1|PTPMT1]]|0.514|
|[[:human genes:c:chchd4|CHCHD4]]|0.512|
|[[:human genes:g:gemin7|GEMIN7]]|0.51|
|[[:human genes:r:rft1|RFT1]]|0.51|
|[[:human genes:g:gatc|GATC]]|0.51|
|[[:human genes:r:romo1|ROMO1]]|0.51|
|[[:human genes:n:nars2|NARS2]]|0.509|
|[[:human genes:m:mrpl53|MRPL53]]|0.504|
|[[:human genes:r:rabggtb|RABGGTB]]|0.504|
|[[:human genes:m:msto1|MSTO1]]|0.504|
|[[:human genes:m:mrps18a|MRPS18A]]|0.5|
|[[:human genes:u:urm1|URM1]]|0.5|
|[[:human genes:e:ears2|EARS2]]|0.498|
|[[:human genes:p:polg|POLG]]|0.498|
|[[:human genes:r:rpusd4|RPUSD4]]|0.497|
|[[:human genes:r:rpe|RPE]]|0.497|
|[[:human genes:s:slc25a26|SLC25A26]]|0.497|
|[[:human genes:t:tars2|TARS2]]|0.496|
|[[:human genes:p:ptar1|PTAR1]]|0.495|
|[[:human genes:e:elp6|ELP6]]|0.493|
|[[:human genes:a:alg3|ALG3]]|0.49|
|[[:human genes:t:tmem242|TMEM242]]|0.489|
|[[:human genes:g:gfm1|GFM1]]|0.488|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.486|
|[[:human genes:a:atic|ATIC]]|0.486|
|[[:human genes:p:ptdss1|PTDSS1]]|0.485|
|[[:human genes:d:dohh|DOHH]]|0.484|
|[[:human genes:t:tamm41|TAMM41]]|0.484|
|[[:human genes:a:atp5a1|ATP5A1]]|0.483|
|[[:human genes:l:lars2|LARS2]]|0.482|
|[[:human genes:d:dpm3|DPM3]]|0.48|
|[[:human genes:e:elp3|ELP3]]|0.478|
|[[:human genes:m:mrpl47|MRPL47]]|0.477|
|[[:human genes:p:pdap1|PDAP1]]|0.477|
|[[:human genes:v:vezt|VEZT]]|0.477|
|[[:human genes:c:c10orf2|C10orf2]]|0.473|
|[[:human genes:m:mrps24|MRPS24]]|0.471|
|[[:human genes:m:mrp63|MRP63]]|0.47|
|[[:human genes:m:mrps26|MRPS26]]|0.469|
|[[:human genes:p:pgs1|PGS1]]|0.467|
|[[:human genes:p:pggt1b|PGGT1B]]|0.466|
|[[:human genes:r:rpp21|RPP21]]|0.466|
|[[:human genes:v:vars2|VARS2]]|0.466|
|[[:human genes:s:spr|SPR]]|0.465|
|[[:human genes:d:dpm1|DPM1]]|0.465|
|[[:human genes:t:trmt10a|TRMT10A]]|0.464|
|[[:human genes:a:atp2a2|ATP2A2]]|0.463|
|[[:human genes:e:eef1e1|EEF1E1]]|0.463|
|[[:human genes:u:ube2g2|UBE2G2]]|0.462|
|[[:human genes:m:mrps16|MRPS16]]|0.462|
|[[:human genes:m:mrps33|MRPS33]]|0.461|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.46|
|[[:human genes:t:tufm|TUFM]]|0.459|
|[[:human genes:m:mrps2|MRPS2]]|0.459|
|[[:human genes:c:c1d|C1D]]|0.458|
|[[:human genes:a:atp5j|ATP5J]]|0.458|
|[[:human genes:e:elac2|ELAC2]]|0.457|
|[[:human genes:g:gemin8|GEMIN8]]|0.456|
|[[:human genes:g:gfpt1|GFPT1]]|0.456|
|[[:human genes:s:sars2|SARS2]]|0.454|
|[[:human genes:g:gemin6|GEMIN6]]|0.454|
|[[:human genes:c:c12orf65|C12orf65]]|0.454|
|[[:human genes:e:eif3f|EIF3F]]|0.453|
|[[:human genes:e:elp2|ELP2]]|0.451|
|[[:human genes:q:qrsl1|QRSL1]]|0.451|
|[[:human genes:t:tkt|TKT]]|0.451|
|[[:human genes:m:mocs3|MOCS3]]|0.45|
|[[:human genes:c:cdipt|CDIPT]]|0.45|
|[[:human genes:c:cept1|CEPT1]]|0.45|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.449|
|[[:human genes:g:gfm2|GFM2]]|0.449|
|[[:human genes:p:ppp6c|PPP6C]]|0.449|
|[[:human genes:r:rars2|RARS2]]|0.448|
|[[:human genes:h:hccs|HCCS]]|0.448|
|[[:human genes:t:tpk1|TPK1]]|0.446|
|[[:human genes:c:c15orf41|C15orf41]]|0.446|
|[[:human genes:z:zrsr2|ZRSR2]]|0.445|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.444|
|[[:human genes:a:alg9|ALG9]]|0.441|
|[[:human genes:m:mrps21|MRPS21]]|0.441|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.44|
|[[:human genes:t:tefm|TEFM]]|0.44|
|[[:human genes:p:pik3r4|PIK3R4]]|0.44|
|[[:human genes:c:c17orf89|C17orf89]]|0.44|
|[[:human genes:a:alg13|ALG13]]|0.44|
|[[:human genes:t:timm22|TIMM22]]|0.439|
|[[:human genes:p:pdcd5|PDCD5]]|0.437|
|[[:human genes:u:uso1|USO1]]|0.437|
|[[:human genes:n:nbn|NBN]]|0.437|
|[[:human genes:a:alg5|ALG5]]|0.436|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.436|
|[[:human genes:c:cxorf56|CXorf56]]|0.436|
|[[:human genes:a:atp5c1|ATP5C1]]|0.435|
|[[:human genes:m:mrps17|MRPS17]]|0.435|
|[[:human genes:w:wbscr16|WBSCR16]]|0.434|
|[[:human genes:c:cox16|COX16]]|0.433|
|[[:human genes:u:uhrf1|UHRF1]]|0.432|
|[[:human genes:m:mbtps1|MBTPS1]]|0.432|
|[[:human genes:p:polg2|POLG2]]|0.432|
|[[:human genes:a:atp5d|ATP5D]]|0.431|
|[[:human genes:v:vma21|VMA21]]|0.429|
|[[:human genes:u:uba5|UBA5]]|0.429|
|[[:human genes:a:atp5b|ATP5B]]|0.427|
|[[:human genes:s:sec63|SEC63]]|0.427|
|[[:human genes:n:n6amt1|N6AMT1]]|0.427|
|[[:human genes:d:ddx20|DDX20]]|0.427|
|[[:human genes:h:hars2|HARS2]]|0.427|
|[[:human genes:c:cox15|COX15]]|0.426|
|[[:human genes:c:c11orf57|C11orf57]]|0.426|
|[[:human genes:d:ddx39a|DDX39A]]|0.426|
|[[:human genes:e:exoc4|EXOC4]]|0.426|
|[[:human genes:t:ttc4|TTC4]]|0.425|
|[[:human genes:c:crls1|CRLS1]]|0.425|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.424|
|[[:human genes:t:taz|TAZ]]|0.423|
|[[:human genes:m:mrpl15|MRPL15]]|0.423|
|[[:human genes:c:ctu1|CTU1]]|0.423|
|[[:human genes:t:tsen54|TSEN54]]|0.419|
|[[:human genes:t:taf1a|TAF1A]]|0.417|
|[[:human genes:o:opa1|OPA1]]|0.417|
|[[:human genes:c:cox5a|COX5A]]|0.415|
|[[:human genes:d:dnajc3|DNAJC3]]|0.413|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.411|
|[[:human genes:d:dnajb11|DNAJB11]]|0.411|
|[[:human genes:p:psmg2|PSMG2]]|0.41|
|[[:human genes:u:ugp2|UGP2]]|0.409|
|[[:human genes:d:dhps|DHPS]]|0.409|
|[[:human genes:l:lsm11|LSM11]]|0.409|
|[[:human genes:a:atp5o|ATP5O]]|0.409|
|[[:human genes:f:faf2|FAF2]]|0.409|
|[[:human genes:m:mtg1|MTG1]]|0.407|
|[[:human genes:m:mrpl11|MRPL11]]|0.406|
|[[:human genes:m:mrps9|MRPS9]]|0.406|
|[[:human genes:u:uqcrq|UQCRQ]]|0.406|
|[[:human genes:t:tbcb|TBCB]]|0.406|
|[[:human genes:c:cox7b|COX7B]]|0.404|
|[[:human genes:f:fancc|FANCC]]|0.404|
|[[:human genes:m:mrpl12|MRPL12]]|0.403|
|[[:human genes:t:tmem41b|TMEM41B]]|0.402|
|[[:human genes:a:atp5h|ATP5H]]|0.402|
|[[:human genes:u:uqcr10|UQCR10]]|0.402|
|[[:human genes:m:mrps23|MRPS23]]|0.401|
|[[:human genes:c:ctc1|CTC1]]|0.4|
|[[:human genes:w:wars2|WARS2]]|0.4|
|[[:human genes:u:ufc1|UFC1]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 54/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|1/26|
|bone|0/26|
|breast|1/30|
|central nervous system|1/49|
|cervix|1/4|
|colorectal|1/17|
|esophagus|1/11|
|fibroblast|0/1|
|gastric|3/14|
|kidney|1/18|
|liver|5/19|
|lung|1/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|2/22|
|peripheral nervous system|1/15|
|plasma cell|1/12|
|prostate|0/1|
|skin|1/20|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|6/22|
|urinary tract|3/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4180
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHRSX Expression in NALM6 Cells: 2.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>