======= DHX30 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DHX30
  * **<color #00a2e8>Official Name</color>**: DExH-box helicase 30
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22907|22907]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7L2E3|Q7L2E3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DHX30&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DHX30|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/616423|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays an important role in the assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). Required for optimal function of the zinc-finger antiviral protein ZC3HAV1 (By similarity). Associates with mitochondrial DNA (PubMed:18063578). {ECO:0000250|UniProtKB:Q5BJS0, ECO:0000269|PubMed:18063578, ECO:0000269|PubMed:25683715}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Helicase C|
|OB NTP bind|
|DEAD|
|HA2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial large ribosomal subunit assembly|
|mitochondrial ribosome assembly|
|G-quadruplex RNA binding|
|ribonucleoprotein granule|
|3-5 RNA helicase activity|
|ribosomal large subunit assembly|
|mitochondrial nucleoid|
|DNA helicase activity|
|RNA helicase activity|
|ribosome assembly|
|double-stranded RNA binding|
|ribosomal large subunit biogenesis|
|DNA duplex unwinding|
|DNA geometric change|
|ribonucleoprotein complex assembly|
|ribonucleoprotein complex subunit organization|
|DNA conformation change|
|ribosome biogenesis|
|chromatin binding|
|ribonucleoprotein complex biogenesis|
|organelle assembly|
|cellular protein-containing complex assembly|
|central nervous system development|
|chromosome organization|
|mitochondrion|
|RNA binding|
|ATP binding|
|protein-containing complex assembly|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-2.15|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-2.05|
|[[:results:exp358|FK-506 5μM R07 exp358]]|-1.83|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.83|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|-1.75|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.71|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.75|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.8|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.47|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps14|MRPS14]]|0.519|
|[[:human genes:m:mrpl21|MRPL21]]|0.518|
|[[:human genes:c:cox16|COX16]]|0.514|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.51|
|[[:human genes:m:mrps34|MRPS34]]|0.5|
|[[:human genes:s:slc25a26|SLC25A26]]|0.498|
|[[:human genes:y:yars2|YARS2]]|0.497|
|[[:human genes:m:mrps6|MRPS6]]|0.497|
|[[:human genes:s:selrc1|SELRC1]]|0.495|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.494|
|[[:human genes:m:mrps18a|MRPS18A]]|0.489|
|[[:human genes:r:rpusd4|RPUSD4]]|0.488|
|[[:human genes:g:gfm1|GFM1]]|0.487|
|[[:human genes:m:mrpl12|MRPL12]]|0.484|
|[[:human genes:f:fastkd5|FASTKD5]]|0.483|
|[[:human genes:m:mtpap|MTPAP]]|0.481|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.479|
|[[:human genes:t:timm8b|TIMM8B]]|0.479|
|[[:human genes:m:mrpl15|MRPL15]]|0.476|
|[[:human genes:c:c10orf2|C10orf2]]|0.473|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.472|
|[[:human genes:g:gfm2|GFM2]]|0.471|
|[[:human genes:m:mrps5|MRPS5]]|0.471|
|[[:human genes:h:hccs|HCCS]]|0.47|
|[[:human genes:b:bcs1l|BCS1L]]|0.466|
|[[:human genes:m:mrpl47|MRPL47]]|0.465|
|[[:human genes:m:mtg2|MTG2]]|0.465|
|[[:human genes:v:vars2|VARS2]]|0.464|
|[[:human genes:m:mrpl23|MRPL23]]|0.463|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.463|
|[[:human genes:m:mrps10|MRPS10]]|0.461|
|[[:human genes:t:tars2|TARS2]]|0.461|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.454|
|[[:human genes:r:rpe|RPE]]|0.454|
|[[:human genes:n:ndufa3|NDUFA3]]|0.453|
|[[:human genes:p:pars2|PARS2]]|0.452|
|[[:human genes:m:mrps26|MRPS26]]|0.45|
|[[:human genes:c:coq3|COQ3]]|0.449|
|[[:human genes:c:c12orf65|C12orf65]]|0.449|
|[[:human genes:m:mrps2|MRPS2]]|0.447|
|[[:human genes:w:wbscr16|WBSCR16]]|0.447|
|[[:human genes:s:sars2|SARS2]]|0.447|
|[[:human genes:n:nars2|NARS2]]|0.446|
|[[:human genes:d:dap3|DAP3]]|0.446|
|[[:human genes:p:pnpt1|PNPT1]]|0.445|
|[[:human genes:t:tufm|TUFM]]|0.443|
|[[:human genes:s:sco2|SCO2]]|0.443|
|[[:human genes:c:cox6c|COX6C]]|0.442|
|[[:human genes:m:mrpl55|MRPL55]]|0.44|
|[[:human genes:n:ndufc2|NDUFC2]]|0.439|
|[[:human genes:p:polg2|POLG2]]|0.438|
|[[:human genes:c:cycs|CYCS]]|0.436|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.434|
|[[:human genes:m:mrps16|MRPS16]]|0.434|
|[[:human genes:q:qrsl1|QRSL1]]|0.434|
|[[:human genes:r:rbfa|RBFA]]|0.432|
|[[:human genes:d:dars2|DARS2]]|0.428|
|[[:human genes:m:mrpl53|MRPL53]]|0.426|
|[[:human genes:f:ftsj2|FTSJ2]]|0.426|
|[[:human genes:n:ndufb3|NDUFB3]]|0.425|
|[[:human genes:t:triap1|TRIAP1]]|0.425|
|[[:human genes:c:coa6|COA6]]|0.424|
|[[:human genes:c:c17orf89|C17orf89]]|0.424|
|[[:human genes:m:mrp63|MRP63]]|0.424|
|[[:human genes:m:mrpl36|MRPL36]]|0.422|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.422|
|[[:human genes:m:mrpl13|MRPL13]]|0.421|
|[[:human genes:t:tefm|TEFM]]|0.421|
|[[:human genes:f:fars2|FARS2]]|0.418|
|[[:human genes:n:ndufb5|NDUFB5]]|0.417|
|[[:human genes:l:lars2|LARS2]]|0.417|
|[[:human genes:c:cox15|COX15]]|0.416|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.416|
|[[:human genes:c:crls1|CRLS1]]|0.415|
|[[:human genes:c:coq2|COQ2]]|0.415|
|[[:human genes:p:polrmt|POLRMT]]|0.415|
|[[:human genes:t:tmem242|TMEM242]]|0.414|
|[[:human genes:m:mterfd2|MTERFD2]]|0.414|
|[[:human genes:m:mrpl2|MRPL2]]|0.413|
|[[:human genes:c:chchd1|CHCHD1]]|0.413|
|[[:human genes:m:mrps11|MRPS11]]|0.412|
|[[:human genes:p:ptrhd1|PTRHD1]]|0.411|
|[[:human genes:c:chchd4|CHCHD4]]|0.41|
|[[:human genes:c:cox17|COX17]]|0.408|
|[[:human genes:m:mrps21|MRPS21]]|0.407|
|[[:human genes:p:pdss1|PDSS1]]|0.407|
|[[:human genes:m:mrps9|MRPS9]]|0.407|
|[[:human genes:m:mrpl4|MRPL4]]|0.406|
|[[:human genes:m:mrpl44|MRPL44]]|0.405|
|[[:human genes:g:gatc|GATC]]|0.405|
|[[:human genes:p:pet100|PET100]]|0.404|
|[[:human genes:m:mrpl3|MRPL3]]|0.403|
|[[:human genes:u:uqcr10|UQCR10]]|0.403|
|[[:human genes:n:ndufb11|NDUFB11]]|0.402|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1180
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DHX30 Expression in NALM6 Cells: 7.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>