======= DLC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLC1
  * **<color #00a2e8>Official Name</color>**: DLC1 Rho GTPase activating protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10395|10395]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96QB1|Q96QB1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604258|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a GTPase-activating protein (GAP) that is a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins. GAP family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal changes. This gene functions as a tumor suppressor gene in a number of common cancers, including prostate, lung, colorectal, and breast cancers. Multiple transcript variants due to alternative promoters and alternative splicing have been found for this gene.[provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|RhoGAP|
|START|
|SAM 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of execution phase of apoptosis|
|negative regulation of focal adhesion assembly|
|negative regulation of stress fiber assembly|
|negative regulation of adherens junction organization|
|negative regulation of Rho protein signal transduction|
|negative regulation of cell junction assembly|
|negative regulation of actin filament bundle assembly|
|focal adhesion assembly|
|cell-substrate adherens junction assembly|
|adherens junction assembly|
|SH2 domain binding|
|negative regulation of cell-matrix adhesion|
|hindbrain morphogenesis|
|regulation of execution phase of apoptosis|
|cell-substrate junction assembly|
|positive regulation of protein dephosphorylation|
|negative regulation of Ras protein signal transduction|
|cortical actin cytoskeleton|
|positive regulation of dephosphorylation|
|negative regulation of small GTPase mediated signal transduction|
|regulation of cell-substrate junction assembly|
|regulation of focal adhesion assembly|
|negative regulation of cell-substrate adhesion|
|regulation of adherens junction organization|
|caveola|
|regulation of stress fiber assembly|
|adherens junction organization|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of actomyosin structure organization|
|regulation of cell junction assembly|
|neural tube closure|
|tube closure|
|regulation of actin filament bundle assembly|
|ruffle membrane|
|primary neural tube formation|
|neural tube formation|
|regulation of cell-matrix adhesion|
|embryonic epithelial tube formation|
|cell-matrix adhesion|
|negative regulation of supramolecular fiber organization|
|epithelial tube formation|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of cytoskeleton organization|
|regulation of protein dephosphorylation|
|regulation of Rho protein signal transduction|
|morphogenesis of embryonic epithelium|
|tube formation|
|hindbrain development|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of cell shape|
|lipid binding|
|neural tube development|
|cell junction assembly|
|positive regulation of endopeptidase activity|
|cell-substrate adhesion|
|positive regulation of peptidase activity|
|regulation of cell-substrate adhesion|
|regulation of dephosphorylation|
|cell junction organization|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|regulation of cysteine-type endopeptidase activity|
|regulation of Ras protein signal transduction|
|heart morphogenesis|
|negative regulation of cell migration|
|regulation of actin filament organization|
|negative regulation of cell adhesion|
|negative regulation of cell motility|
|GTPase activator activity|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|regulation of actin cytoskeleton organization|
|regulation of small GTPase mediated signal transduction|
|regulation of supramolecular fiber organization|
|positive regulation of proteolysis|
|negative regulation of organelle organization|
|forebrain development|
|regulation of actin filament-based process|
|positive regulation of GTPase activity|
|focal adhesion|
|regulation of endopeptidase activity|
|morphogenesis of an epithelium|
|regulation of peptidase activity|
|regulation of GTPase activity|
|regulation of cell morphogenesis|
|actin cytoskeleton organization|
|negative regulation of intracellular signal transduction|
|heart development|
|regulation of cytoskeleton organization|
|tissue morphogenesis|
|embryonic morphogenesis|
|actin filament-based process|
|chordate embryonic development|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|regulation of cell adhesion|
|positive regulation of cell death|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|brain development|
|positive regulation of hydrolase activity|
|head development|
|tube development|
|regulation of cell migration|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|apoptotic process|
|cell adhesion|
|biological adhesion|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|embryo development|
|central nervous system development|
|regulation of locomotion|
|regulation of cellular component movement|
|programmed cell death|
|regulation of anatomical structure morphogenesis|
|cell death|
|cytoskeleton organization|
|epithelium development|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of protein modification process|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|regulation of cell death|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.538|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15992
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLC1 Expression in NALM6 Cells: 0.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>