======= DLG2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLG2
  * **<color #00a2e8>Official Name</color>**: discs large MAGUK scaffold protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1740|1740]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15700|Q15700]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLG2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLG2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603583|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. The encoded protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described, but their full-length nature is not known. [provided by RefSeq, Dec 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ|
|SH3 2|
|Guanylate kin|
|MAGUK N PEST|
|SH3 1|
|L27 1|
|PDZ assoc|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|retrograde axonal protein transport|
|structural constituent of postsynaptic density|
|maintenance of postsynaptic density structure|
|maintenance of postsynaptic specialization structure|
|anterograde axonal protein transport|
|guanylate kinase activity|
|protein localization to presynapse|
|cellular response to potassium ion|
|juxtaparanode region of axon|
|GDP metabolic process|
|protein localization to postsynaptic specialization membrane|
|neurotransmitter receptor localization to postsynaptic specialization membrane|
|axo-dendritic protein transport|
|ionotropic glutamate receptor complex|
|response to potassium ion|
|GMP metabolic process|
|maintenance of synapse structure|
|postsynaptic density organization|
|retrograde axonal transport|
|postsynaptic specialization organization|
|postsynaptic density membrane|
|ionotropic glutamate receptor binding|
|protein localization to postsynaptic membrane|
|regulation of NMDA receptor activity|
|purine ribonucleoside monophosphate metabolic process|
|purine nucleoside monophosphate metabolic process|
|guanosine-containing compound metabolic process|
|receptor localization to synapse|
|anterograde axonal transport|
|cellular component maintenance|
|establishment or maintenance of epithelial cell apical/basal polarity|
|receptor clustering|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment or maintenance of apical/basal cell polarity|
|establishment or maintenance of bipolar cell polarity|
|ribonucleoside monophosphate metabolic process|
|axonal transport|
|axon cytoplasm|
|purine ribonucleoside metabolic process|
|purine nucleoside diphosphate metabolic process|
|purine ribonucleoside diphosphate metabolic process|
|protein localization to synapse|
|purine nucleoside metabolic process|
|ribonucleoside diphosphate metabolic process|
|regulation of glutamate receptor signaling pathway|
|axo-dendritic transport|
|protein transport along microtubule|
|microtubule-based protein transport|
|nucleoside monophosphate metabolic process|
|sensory perception of pain|
|regulation of neurotransmitter receptor activity|
|ribonucleoside metabolic process|
|neuromuscular junction|
|nucleoside diphosphate metabolic process|
|voltage-gated potassium channel complex|
|localization within membrane|
|postsynapse organization|
|kinase binding|
|negative regulation of phosphatase activity|
|nucleoside metabolic process|
|negative regulation of dephosphorylation|
|glycosyl compound metabolic process|
|transport along microtubule|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|cytoskeleton-dependent intracellular transport|
|regulation of phosphatase activity|
|microtubule-based transport|
|cellular response to metal ion|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|regulation of dephosphorylation|
|cellular response to inorganic substance|
|protein localization to cell periphery|
|postsynaptic density|
|protein-containing complex localization|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|synapse organization|
|microtubule-based movement|
|regulation of transporter activity|
|purine ribonucleotide metabolic process|
|neuron projection|
|ribonucleotide metabolic process|
|purine nucleotide metabolic process|
|regulation of cation transmembrane transport|
|ribose phosphate metabolic process|
|glutamatergic synapse|
|purine-containing compound metabolic process|
|response to metal ion|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|trans-synaptic signaling|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|negative regulation of hydrolase activity|
|synaptic signaling|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|cell-cell adhesion|
|response to inorganic substance|
|nucleobase-containing small molecule metabolic process|
|cell junction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|microtubule-based process|
|regulation of ion transport|
|protein localization to organelle|
|negative regulation of catalytic activity|
|organophosphate metabolic process|
|cell adhesion|
|biological adhesion|
|sensory perception|
|protein phosphorylation|
|intracellular protein transport|
|carbohydrate derivative metabolic process|
|cell-cell signaling|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|phosphorylation|
|nervous system process|
|protein transport|
|intracellular transport|
|peptide transport|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|intracellular signal transduction|
|small molecule metabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|regulation of transport|
|system process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.8|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.91|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.27|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.43|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16162
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLG2 Expression in NALM6 Cells: 0.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>