======= DLG3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: DLG3
  * **<color #00a2e8>Official Name</color>**: discs large MAGUK scaffold protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=1741|1741]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q92796|Q92796]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=DLG3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20DLG3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300189|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PDZ assoc|
|SH3 1|
|PDZ|
|Guanylate kin|
|SH3 2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|structural constituent of postsynaptic density|
|maintenance of postsynaptic density structure|
|maintenance of postsynaptic specialization structure|
|ionotropic glutamate receptor complex|
|maintenance of synapse structure|
|postsynaptic density organization|
|postsynaptic density, intracellular component|
|postsynaptic specialization organization|
|postsynaptic density membrane|
|establishment of planar polarity|
|establishment of tissue polarity|
|AMPA glutamate receptor complex|
|ionotropic glutamate receptor binding|
|dendritic shaft|
|regulation of NMDA receptor activity|
|receptor localization to synapse|
|morphogenesis of a polarized epithelium|
|establishment or maintenance of epithelial cell apical/basal polarity|
|cellular component maintenance|
|receptor clustering|
|regulation of postsynaptic membrane neurotransmitter receptor levels|
|establishment or maintenance of bipolar cell polarity|
|phosphatase binding|
|establishment or maintenance of apical/basal cell polarity|
|positive regulation of protein tyrosine kinase activity|
|protein localization to synapse|
|regulation of glutamate receptor signaling pathway|
|regulation of neurotransmitter receptor activity|
|neuromuscular junction|
|localization within membrane|
|protein phosphatase binding|
|postsynapse organization|
|PDZ domain binding|
|regulation of protein tyrosine kinase activity|
|kinase binding|
|negative regulation of phosphatase activity|
|negative regulation of dephosphorylation|
|bicellular tight junction|
|growth cone|
|regulation of cation channel activity|
|regulation of signaling receptor activity|
|regulation of phosphatase activity|
|protein C-terminus binding|
|positive regulation of peptidyl-tyrosine phosphorylation|
|establishment or maintenance of cell polarity|
|basolateral plasma membrane|
|regulation of dephosphorylation|
|regulation of peptidyl-tyrosine phosphorylation|
|protein-containing complex localization|
|regulation of ion transmembrane transporter activity|
|regulation of transmembrane transporter activity|
|synapse organization|
|regulation of transporter activity|
|ubiquitin protein ligase binding|
|neuron projection|
|regulation of cation transmembrane transport|
|glutamatergic synapse|
|neuronal cell body|
|MAPK cascade|
|signal transduction by protein phosphorylation|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|morphogenesis of an epithelium|
|trans-synaptic signaling|
|negative regulation of hydrolase activity|
|synaptic signaling|
|regulation of ion transmembrane transport|
|protein localization to membrane|
|cell-cell adhesion|
|positive regulation of protein kinase activity|
|cell junction|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|regulation of transmembrane transport|
|tissue morphogenesis|
|positive regulation of kinase activity|
|positive regulation of transferase activity|
|negative regulation of cell population proliferation|
|regulation of ion transport|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|regulation of kinase activity|
|cell adhesion|
|biological adhesion|
|protein phosphorylation|
|regulation of transferase activity|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|epithelium development|
|cell-cell signaling|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|negative regulation of molecular function|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.68|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|-2.36|
|[[:results:exp152|SGC2043 10μM R03 exp152]]|1.74|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16204
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.42 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='DLG3 Expression in NALM6 Cells: 4.42'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>